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Natural intestinal flora involved in the emergence of multiple sclerosis
Date:10/27/2011

em is the driving force here," says Hartmut Wekerle, Director at the Max Planck Institute in Martinsried.

The scientists are certain that the intestinal flora can also trigger an overreaction of the immune system against the myelin layer in persons with a genetic predisposition for multiple sclerosis. Therefore, nutrition may play a central role in the disease, as diet largely determines the bacteria that colonise the intestines. "Changing eating habits could explain, for example, why the incidence of multiple sclerosis has increased in Asian countries in recent years," explains Hartmut Wekerle.

Precisely which bacteria are involved in the emergence of multiple sclerosis remains unclear. Possible candidates are clostridiums, which can have direct contact with the intestinal wall. They are also a natural component of healthy intestinal flora but could possibly activate the T cells in persons with a genetic predisposition. The scientists would now like to analyse the entire microbial genome of patients with multiple sclerosis and thereby identify the differences in the intestinal flora of healthy people and multiple sclerosis patients.


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Contact: Dr Gurumoorthy Krishnamoorthy
guru@neuro.mpg.de
49-898-578-3561
Max-Planck-Gesellschaft
Source:Eurekalert  

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