Navigation Links
Natural insecticide re-created in the lab
Date:8/22/2007

Twenty-two years of dedicated research has finally resulted in success: In the journal Angewandte Chemie, a British team headed by Steven V. Ley at the University of Cambridge reports the first synthesis of azadirachtin, a natural compound that stops predatory insects from feeding.

Plants have a variety of defense mechanisms to deter insect attack. Investigation of these mechanisms often allows researchers to discover molecules with interesting biological properties. One such compound is azadirachtin, which was first isolated from the neem tree (also known as the Indian lilac) in 1968. The name of this natural product is derived from the botanical name of the plant, Azadiracta indica. Azadirachtin is a highly active substance that inhibits the development of the larvae of a broad spectrum of destructive insects but is harmless to mammals and beneficial insects, such as bees and ladybugs.

The structure of this complicated molecule was published in 1985, after a long, intensive research effort, but all attempts to make this compound have thus far been unsuccessful. The difficulty of the synthesis stems in part from the 16 stereocenters in the molecule, the complex pattern of oxygen-containing functional groups, and a conformation and reactivity that are strongly dependent on intramolecular bridging hydrogen bonds. The compound is highly light sensitive and can readily undergo structural rearrangement.

Ley and his team have been interested in solving the problem of the synthesis of this compound for 22 years. Their endurance has now been abundantly rewarded. The key steps in making this molecule involve a Claisen rearrangement and a novel radical cyclization reaction.

While we have been working on this complex synthesis, says Ley, we have also developed a number of new methods that are of general use for the construction of other important molecules. Ley expects that using the successful synthetic route will allow the development of simpler derivatives of azadirachtin that are stable and may lead to a new generation of environmentally acceptable insecticides.


'/>"/>

Contact: Steven V. Ley
svl1000@cam.ac.uk
44-122-333-6398
John Wiley & Sons, Inc.
Source:Eurekalert

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. UCSD discovery may help extend life of natural pesticide
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. UCLA scientists store materials in cells natural vaults
6. Man-made wetlands effectiveness similar to natural marsh
7. Natural Killers Could Lead to New Hepatitis Treatments
8. Researchers pioneer new gene therapy technique using natural repair process
9. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Naturally occurring asbestos linked to lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
(Date:10/9/2017)... , ... October 09, 2017 , ... At its national ... Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has been ... a member of the winning team for the 2015 Breakthrough Prize in Fundamental physics ...
Breaking Biology Technology: