Navigation Links
Natural insecticide re-created in the lab
Date:8/22/2007

Twenty-two years of dedicated research has finally resulted in success: In the journal Angewandte Chemie, a British team headed by Steven V. Ley at the University of Cambridge reports the first synthesis of azadirachtin, a natural compound that stops predatory insects from feeding.

Plants have a variety of defense mechanisms to deter insect attack. Investigation of these mechanisms often allows researchers to discover molecules with interesting biological properties. One such compound is azadirachtin, which was first isolated from the neem tree (also known as the Indian lilac) in 1968. The name of this natural product is derived from the botanical name of the plant, Azadiracta indica. Azadirachtin is a highly active substance that inhibits the development of the larvae of a broad spectrum of destructive insects but is harmless to mammals and beneficial insects, such as bees and ladybugs.

The structure of this complicated molecule was published in 1985, after a long, intensive research effort, but all attempts to make this compound have thus far been unsuccessful. The difficulty of the synthesis stems in part from the 16 stereocenters in the molecule, the complex pattern of oxygen-containing functional groups, and a conformation and reactivity that are strongly dependent on intramolecular bridging hydrogen bonds. The compound is highly light sensitive and can readily undergo structural rearrangement.

Ley and his team have been interested in solving the problem of the synthesis of this compound for 22 years. Their endurance has now been abundantly rewarded. The key steps in making this molecule involve a Claisen rearrangement and a novel radical cyclization reaction.

While we have been working on this complex synthesis, says Ley, we have also developed a number of new methods that are of general use for the construction of other important molecules. Ley expects that using the successful synthetic route will allow the development of simpler derivatives of azadirachtin that are stable and may lead to a new generation of environmentally acceptable insecticides.


'/>"/>

Contact: Steven V. Ley
svl1000@cam.ac.uk
44-122-333-6398
John Wiley & Sons, Inc.
Source:Eurekalert

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. UCSD discovery may help extend life of natural pesticide
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. UCLA scientists store materials in cells natural vaults
6. Man-made wetlands effectiveness similar to natural marsh
7. Natural Killers Could Lead to New Hepatitis Treatments
8. Researchers pioneer new gene therapy technique using natural repair process
9. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Naturally occurring asbestos linked to lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
(Date:6/23/2016)... Durham, NC (PRWEB) , ... June 23, 2016 , ... ... Odense University Hospital in Denmark detail how a patient who developed lymphedema after being ... (fat) tissue. The results could change the paradigm for dealing with this debilitating, frequent ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® ... provides a free webinar on Performing Quality Investigations: Getting to Root ... CT at no charge. , Incomplete investigations are still a major concern to ...
Breaking Biology Technology: