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Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
Date:8/31/2009

vely for 18 percent and 9 percent of all cancer deaths in 2009, according to estimates from the American Cancer Society.

In the recent studies, a form of organic selenium found naturally in garlic and Brazil nuts was converted in cancer cells to metabolites that acted as "HDAC inhibitors" a promising field of research in which silenced tumor suppressor genes are re-activated, triggering cancer cell death.

"Whether it's HDAC inhibition leading to one manner of cancer cell growth arrest, or loss of ribonucleotide reductase activity leading to another, as seen with chlorophyllin, there's significant promise in the use of natural products for combined cancer therapies," Dashwood said. "These are areas that merit continued research."


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Contact: Rod Dashwood
rod.dashwood@oregonstate.edu
541-737-0787
Oregon State University
Source:Eurekalert

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