Navigation Links
Natural compound in broccoli could treat devastating genetic skin disorder
Date:12/2/2007

Washington, D.C. -- The compound sulforaphane whose natural precursors are found at high levels in broccoli and other cruciferous vegetables has been hailed for its chemopreventive powers against cancer. Now sulforaphane has demonstrated new skills in treating a genetic skin blistering disorder called epidermolysis bullosa simplex (EBS), Pierre Coulombe and colleagues at the Johns Hopkins University School of Medicine in Baltimore report at the American Society for Cell Biology 47th Annual Meeting.

EBS is a rare but devastating inherited condition in which fluid-filled lesions called bullae appear at sites of frictional trauma to the skin. Unfortunately, treatment options for EBS are limited and palliative in nature. Much work remains to be done before sulforaphane can be tested clinically with EBS patients, but Coulombe notes that extracts from broccoli sprouts rich in sulforaphane have already been shown to be safe for use in human skin.

In EBS patients, the bottom layer of the epidermis, which is made of cells called keratinocytes, is unusually fragile and ruptures readily. Molecularly, most cases of EBS result from mutations in genes that produce the proteins keratin 5 (K5) and keratin 14 (K14). These proteins co-polymerize to form the intermediate filament cytoskeleton in basal keratinocytes. Since the discovery in 1991 that EBS is a keratin-based disease, more than 40 additional disorders affecting a broad range of tissues have been traced to defects in genes that encode intermediate filament proteins.

Coulombe and colleagues turned to sulforaphane in their search for a chemical activator that would induce the production of missing keratins in basal epidermis. There are 54 conserved keratin proteins in mammals -- meaning that evolution favored their survival. Many of these keratins are closely related in their genetic sequences and their properties and by their distribution within epithelial tissues. Coulombe reasoned that
'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural chemical found in broccoli helps combat skin blistering disease
2. Natural insecticide re-created in the lab
3. Researchers develop simple method to create natural drug products
4. Brains timing linked with timescales of the natural visual world
5. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
6. Naturally-occurring apple compounds reduce risk of pancreatic cancer
7. New membrane strips carbon dioxide from natural gas faster and better
8. Natural product discovery by Cleveland medical researchers blocks tissue destruction
9. MU researchers go nano, natural and green
10. Researchers discover natural herbicide released by grass
11. Baker Institute finds increased domestic production wont make US self-sufficient in natural gas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 2015   Guidepoint , a leading global research ... Pain Management TRACKER, part of the Guidepoint TRACKER ... the medical device and therapeutics markets. The Post-Surgical Pain ... volumes, market share, and adoption rates across three major ... surgery. The Post-Surgical Pain Management TRACKER will ...
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced ... Strategic Business Report" report to their offering. This ... US$ Thousands by the following Segments: Face Biometrics, and Voice Biometrics. ... Canada , Japan , Europe ... & Africa , and ...
(Date:3/23/2015)... 23, 2015   HOYOS Labs , a leading ... announced that the Company will demonstrate multiple biometrics-based technologies ... consumers at Connect:ID on March 23 through 25, 2015, ... will highlight the IEEE Biometric Open Protocol Standard; free ... enterprise access control system. BOPS was invented by HOYOS ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... Salmonella have a complicated immune system that helps them ... cell membrane, according to a University of Washington-led study ... research, which also included scientists at the Sidney Kimmel ... for understanding the evolution of disease-causing bacteria. The findings ...
... who are extremely obese may be underestimated as a new ... and high cholesterol than women at lower levels of obesity, ... JAMA. , Obesity diagnosis and treatment are typically based on ... calculated as weight in kilograms divided by height in meters ...
... results, researchers have shown that a drug which mimics the ... develop in the part of the brain where cells are ... long-lasting recovery of function in an animal model of PD. ... PD and other neurodegenerative diseases. The study was funded ...
Cached Biology News:Bacteria have their own immune system protecting against outside DNA 2Higher levels of obesity associated with greater health risks 2Higher levels of obesity associated with greater health risks 3Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's 2Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's 3
(Date:5/5/2015)... May 05, 2015 A comment period ... wide range of key photonics technologies – regulations that ... of U.S. industry. To help the community understand and ... May on the proposed changes to U.S. Munitions ... by International Traffic in Arms Regulations (ITAR). , For ...
(Date:5/5/2015)...  Orexigen Therapeutics, Inc. (Nasdaq: OREX ) will ... Friday, May 8 before the market opens. The announcement ... call at 8:30 a.m. Eastern Time (5:30 a.m. Pacific ... by phone by calling (800) 708-4540 (domestic) or (847) ... accessed live on the Investors section of the Orexigen ...
(Date:5/5/2015)... 05, 2015 Synedgen Inc. is pleased ... Regulatory Affairs Manager. , Dr. Nguyen brings to Synedgen ... for the company as it moves forward in the ... the next two years. Dr. Nguyen will lead the ... regulatory key documents that must be completed in order ...
(Date:5/4/2015)... Tenn. , May 4, 2015   ... developed a significantly better computer tool for finding ... many cancers but were difficult to identify with ... scientific journal Nature Methods . ... for Copy Number Segmentation by Regression Tree in ...
Breaking Biology Technology:Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4Synedgen Announces the Appointment of Regulatory Affairs Manager 2Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4
... have made a breakthrough toward creating nanocircuitry on graphene, ... silicon as the building block of transistors. They have ... thermochemical nanolithography (TCNL) for creating nanowires, tuning the electronic ... thereby allowing it to switch from being an insulating ...
... oxide, a single-atomic-layered material made by reacting graphite powders ... interest from scientists because of its ability to easily ... scientists believe could be used to produce low-cost carbon-based ... assistant professor of materials science and engineering, and his ...
... Germany and LAUSANNE, Switzerland and ... Medicines Initiative for,Diabetes"), a public private consortium funded by ... a project focusing on,pancreatic islet cell function and survival. ... biomarkers and tools to pave the way,for improved disease ...
Cached Biology Technology:Scientists strive to replace silicon with graphene on nanocircuitry 2Scientists strive to replace silicon with graphene on nanocircuitry 3Researchers discover new properties of World's thinnest material 2Launch of IMIDIA - An Innovative Medicines Initiative Project for Diabetes 2Launch of IMIDIA - An Innovative Medicines Initiative Project for Diabetes 3Launch of IMIDIA - An Innovative Medicines Initiative Project for Diabetes 4
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known mammal microRNAs ...
... is critical to the maintenance of ... proteins as important and diverse as ... shock and stress response, antigen presentation, ... ion channels, cell cycle regulation, transcription, ...
... critical to the maintenance of appropriate ... as important and diverse as those ... and stress response, antigen presentation, modulation ... channels, cell cycle regulation, transcription, and ...
Biology Products: