Navigation Links
Natural compound in broccoli could treat devastating genetic skin disorder
Date:12/2/2007

Washington, D.C. -- The compound sulforaphane whose natural precursors are found at high levels in broccoli and other cruciferous vegetables has been hailed for its chemopreventive powers against cancer. Now sulforaphane has demonstrated new skills in treating a genetic skin blistering disorder called epidermolysis bullosa simplex (EBS), Pierre Coulombe and colleagues at the Johns Hopkins University School of Medicine in Baltimore report at the American Society for Cell Biology 47th Annual Meeting.

EBS is a rare but devastating inherited condition in which fluid-filled lesions called bullae appear at sites of frictional trauma to the skin. Unfortunately, treatment options for EBS are limited and palliative in nature. Much work remains to be done before sulforaphane can be tested clinically with EBS patients, but Coulombe notes that extracts from broccoli sprouts rich in sulforaphane have already been shown to be safe for use in human skin.

In EBS patients, the bottom layer of the epidermis, which is made of cells called keratinocytes, is unusually fragile and ruptures readily. Molecularly, most cases of EBS result from mutations in genes that produce the proteins keratin 5 (K5) and keratin 14 (K14). These proteins co-polymerize to form the intermediate filament cytoskeleton in basal keratinocytes. Since the discovery in 1991 that EBS is a keratin-based disease, more than 40 additional disorders affecting a broad range of tissues have been traced to defects in genes that encode intermediate filament proteins.

Coulombe and colleagues turned to sulforaphane in their search for a chemical activator that would induce the production of missing keratins in basal epidermis. There are 54 conserved keratin proteins in mammals -- meaning that evolution favored their survival. Many of these keratins are closely related in their genetic sequences and their properties and by their distribution within epithelial tissues. Coulombe reasoned that
'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural chemical found in broccoli helps combat skin blistering disease
2. Natural insecticide re-created in the lab
3. Researchers develop simple method to create natural drug products
4. Brains timing linked with timescales of the natural visual world
5. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
6. Naturally-occurring apple compounds reduce risk of pancreatic cancer
7. New membrane strips carbon dioxide from natural gas faster and better
8. Natural product discovery by Cleveland medical researchers blocks tissue destruction
9. MU researchers go nano, natural and green
10. Researchers discover natural herbicide released by grass
11. Baker Institute finds increased domestic production wont make US self-sufficient in natural gas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... RIVERSIDE, Calif. -- To reduce fire hazard in the ... of mechanically cutting woody shrubs and suppressed trees (ladder ... then burned during periods of low fire danger in ... burning and minimize hazardous air pollutants, managers often cover ... polyethylene plastic, commonly referred to as agricultural plastic, in ...
(Date:7/24/2014)... study funded by the New Jersey Recovery Fund and ... of Planning and Public Policy at Rutgers University has ... skeptical about the likelihood of community-based rebuilding solutions. Of ... indicated they were "pessimistic" or "very pessimistic" that the ... be rebuilt better than they were before the storm; ...
(Date:7/24/2014)... which life arose have been maintained in our cells today ... Research published today in the Journal of Biological Chemistry ... also in animals still perform ancient reactions thought to have ... billion years ago. , The primordial soup theory suggests that ... of the combination of metals, gases from the atmosphere and ...
Breaking Biology News(10 mins):Study gives new perspective on agricultural plastic, debris burning, and air quality 2Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2
... It just got easier to pinpoint biological hot spots in ... a pinpoint. Microscopic algae are called phytoplankton and range from ... being 1/100th the size of a human hair. But as ... of Vancouver Island, British Columbia, are big players when it ...
... MD FASEB MARC (Minority Access to Research Careers) ... American Society for Bone & Mineral Research (ASBMR) 2010 ... 2010. These awards are meant to promote the ... the mainstream of the basic science community and to ...
... October 6, 2010 - A first-of-its-kind study that tracked the ... tagged in the Hudson River discovered that these fish move ... south as Georgia and as far north as Nova Scotia, ... will need to address long-range oceanic threats to the species ...
Cached Biology News:UW-built device reveals invisible world teeming with microscopic algae 2Study provides data that can inform Atlantic sturgeon recovery efforts 2Study provides data that can inform Atlantic sturgeon recovery efforts 3
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... Yan, Distinguished Professor of Engineering at the University ... to solve problems in energy engineering, environmental sustainability ... on zeolites, porous rock with a well-defined, crystalline ... is so precisely decided that zeolites can separate ... of an angstrom (one-tenth of a nanometer), making ...
(Date:7/24/2014)... July 24, 2014 SRI International has been ... National Institute of Allergy and Infectious Diseases (NIAID), part ... development of potential therapies for HIV infection and AIDS. ... HIV and AIDS and the complications and opportunistic infections ... preventing sexual transmission of HIV. According ...
(Date:7/24/2014)... July 24, 2014 WIRB-Copernicus Group ® ... and ethical review services for clinical research, announced ... a division of Richmond, VA ... biosafety and biosecurity consulting firm in ... WCG,s biosafety division – WCG Biosafety™ – will ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4University of Delaware researcher describes new approach for creating organic zeolites 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3
... Sept. 14 Helix BioPharma Corp. (TSX, FSE: "HBP" / ... list its shares of common stock on the NYSE Amex ... stock will begin trading on the NYSE Amex on September ... delist from the OTCQX once trading begins on the NYSE ...
... 14 The launch of IntriMed Technologies and ... in Oxnard, Calif. were announced today by IntriPlex ... manufacture of ultra-precise components for the data storage ... heritage of engineering innovation, IntriMed ( www.intrimed.com ) ...
... HARBIN, China, Sept. 14 /PRNewswire-Asia-FirstCall/ -- ... ... ... keyed by longUrl, so we need to grab the first one. for (var r in data.results) { ...
Cached Biology Technology:Helix BioPharma Approved for NYSE Amex Listing 2Helix BioPharma Approved for NYSE Amex Listing 3IntriMed Technologies Launched to Address Challenges Faced by Medical Device Manufacturers 2IntriMed Technologies Launched to Address Challenges Faced by Medical Device Manufacturers 3Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 2Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 3Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 4Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 5Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 6Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 7Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 8
...
... receptors constitute the principal excitatory ... classes of glutamate receptors exist: ... Ionotropic glutamate receptors are oligomeric ... NMDA1-3, KAI-2) which comprise ligand-gated ...
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
Recommended fro Western blotting application...
Biology Products: