Navigation Links
Natural chemical found in grapes may protect against Alzheimer's disease
Date:7/15/2011

Researchers at Mount Sinai School of Medicine have found that grape seed polyphenolsa natural antioxidantmay help prevent the development or delay the progression of Alzheimer's disease. The research, led by Giulio Maria Pasinetti, MD, PhD, The Saunder Family Professor in Neurology, and Professor of Psychiatry and Geriatrics and Adult Development at Mount Sinai School of Medicine, was published online in the current issue of the Journal of Alzheimer's Disease.

This is the first study to evaluate the ability of grape-derived polyphenols to prevent the generation of a specific form of β-amyloid (Aβ) peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer disease. In partnership with a team at the University of Minnesota led by Karen Hsiao Ashe, MD, PhD, Dr. Pasinetti and his collaborators administered grape seed polyphenolic extracts to mice genetically determined to develop memory deficits and Aβ neurotoxins similar to those found in Alzheimer's disease. They found that the brain content of the Aβ*56, a specific form of Aβ previously implicated in the promotion of Alzheimer's disease memory loss, was substantially reduced after treatment.

Previous studies suggest that increased consumption of grape-derived polyphenols, whose content, for example, is very high in red wine, may protect against cognitive decline in Alzheimer's. This new finding, showing a selective decrease in the neurotoxin Aβ*56 following grape-derived polyphenols treatment, corroborates those theories.

"Since naturally occurring polyphenols are also generally commercially available as nutritional supplements and have negligible adverse events even after prolonged periods of treatment, this new finding holds significant promise as a preventive method or treatment, and is being tested in translational studies in Alzheimer's disease patients," said Dr. Pasinetti.

The study authors
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of natural compounds that could slow blood vessel growth
2. Design of a compound that stabilizes the main natural suppressor of tumors
3. International Council for Science launches major research program on natural disasters
4. Natural and social sciences: ICSU embraces the need to work more closely together
5. Ecologists say metabolism accounts for why natural selection favors only some species
6. Natural Capital Project to develop conservation software
7. Honey adds health benefits, is natural preservative and sweetener in salad dressings
8. New research shows how gene function drives natural selection in important class of genetic elements
9. Apolipoprotein(a): A natural regulator of inflammation
10. Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
11. Particulate emission from natural gas burning home appliances
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... 28, 2015 According to a ... by Assessment Type (Pen & Paper Based, Hosted, Biometrics), ... Learning, Academic Research), Vertical and Region - Global Forecast ... Market to grow from USD 2.4 Billion in 2015 ... Annual Growth Rate (CAGR) of 25.6% from 2015 to ...
(Date:8/26/2015)... PUNE, India , August 26, 2015 ... (Two, Three, Four, and Five Factor), Application (Travel & ... and Geography - Global Forecast to 2020", published by ... 9.60 Billion by 2020, growing at a CAGR of ... 71 Tables and 82 F igures spread through ...
(Date:8/25/2015)... and BELLEVUE, Wash. , Aug. ... advanced robotic systems, announced today it will unveil its ... vehicle (UGV), at the National Tactical Officers Association Conference ... The Guardian S is the first-ever commercially available ... years of research and in-field trials and is protected ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3
... Valladolid (Spain) has analysed 40 brands of beer, discovering that ... beers. Iron is essential to the human diet, but also ... and flavour. According to the analysis carried out by ... from all 5 continents, dark beers have an average free ...
... AUSTIN, Texas Just as the rainy season is driving ... computational model could forecast where outbreaks are likely to occur. ... Centers for Disease Control and Prevention (CDC) on the project, ... most needed in the earthquake-ravaged country. Just back from ...
... team of scientists has identified 29 new genetic variants ... biology of an important and very debilitating neurological disease. ... common neurological conditions among young adults, affects around 2.5 ... attacks the central nervous system (CNS), which includes the ...
Cached Biology News:Dark beer has more iron than pale beer 2Researchers fight cholera with computer forecasting 2Researchers fight cholera with computer forecasting 3Researchers fight cholera with computer forecasting 4Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis 2
(Date:8/27/2015)... Aug. 27, 2015  Neogen Corporation (NASDAQ: NEOG ... of United Kingdom -based Lab M ... media and diagnostic systems. Lab M ... leading provider of microbial testing and diagnostic products for ... The company currently sells into more than 70 countries ...
(Date:8/27/2015)... PARK, Calif. , Aug. 27, 2015  Asterias ... in the emerging field of regenerative medicine, today announced ... investor conferences in the month of September.  ... will present at Rodman & Renshaw,s 17th Annual Global ... ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... -- GlassesOff (OTCBB: GLSO), a visual neuroscience technology ... vision system, announced today a partnership with eight-time All-Star, ... to develop a new mobile app designed for professional ... on-court performance. Vision is the inception of every ... ball or blocking a pass. The critical impact vision speed ...
(Date:8/27/2015)... Aug. 27, 2015 In response to ... UPS and The US Postal Service to no ... as ,select agents, by the CDC, Marken reaffirmed ... these sensitive shipments. Marken uses its ... trained and certified personnel to ensure the safe ...
Breaking Biology Technology:Neogen acquires U.K.-based Lab M Holdings 2Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... May 9 ATS Medical, Inc. (Nasdaq:,ATSI), manufacturer ... that it will participate at the Rodman & ... Meridien Beach Plaza,Hotel in Monte Carlo on Tuesday, ... ATS Medical, will present at 9:20 a.m. local ...
... N.J., May 9 Celator Pharmaceuticals today,announced that ... Jackson joined Celator in October 2007 as Head ... Scott as the new CEO. He brings more ... of specialty,pharmaceutical experience primarily in oncology," said Dr. ...
... China, May 9 /Xinhua-PRNewswire-FirstCall/ -- China-Biotics,Inc. (OTC Bulletin ... specializing in the manufacture, research, development,marketing and distribution ... work for its new plant at Qing Pu, ... 150 MT capacity is the cornerstone of our,growth ...
Cached Biology Technology:ATS Medical to Participate at the Rodman & Renshaw 5th Annual Global Healthcare Conference 2Celator(R) Pharmaceuticals Announces Appointment of Scott Jackson as CEO 2China-Biotics, Inc. Completes Foundation for Its New Plant 2
Red Standard is sodium salt of resorufin....
Human Jagged 2 Biotinylated Affinity Purified PAb...
RayBio L Series 507: RayBio Label-based Antibody Array I (2 membranes) Class: Antibody Array Products Product Group: Antibody Array...
The Zymo-Spin PI Fast-Spin column features durable polypropylene construction and is the same column featured in the His-Spin Protein Miniprep. Capacity is 800 l....
Biology Products: