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Natural chemical found in broccoli helps combat skin blistering disease
Date:8/20/2007

lforaphane triggers the expression of selected keratin genes in skin, says Coulombe. So we began what evolved into a highly rewarding collaboration and found it does indeed work in a mouse model for EBS.

This is the first suggestion that we may be able to treat this terrible disease, adds Talalay, a co-author of this study. And we didnt need to invent a new drug; sulforaphane is naturally found in our diet.

The team will next test whether sulforaphane can stimulate the proper keratin protein in the appropriate subset of human skin cells a vital matter for any future medical hopes. Beyond that are issues of how effective a topical application would be on human skin, which is considerably thicker than mouse skin, as well as examining the long term effects of sulforaphane treatment.

If we can clear these important hurdles, then sulforaphane can potentially be a tremendous therapeutic, with the added benefit of having anticancer properties, Coulombe says. And when you consider that the only current option for EBS is wrapping gauze around trauma-prone areas to minimize breakage, and otherwise avoiding infection and making sure blisters heal properly, then even a mild success would be a significant benefit for these patients.


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Contact: Nick Zagorski
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

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