Navigation Links
Natural chemical found in broccoli helps combat skin blistering disease
Date:8/20/2007

lforaphane triggers the expression of selected keratin genes in skin, says Coulombe. So we began what evolved into a highly rewarding collaboration and found it does indeed work in a mouse model for EBS.

This is the first suggestion that we may be able to treat this terrible disease, adds Talalay, a co-author of this study. And we didnt need to invent a new drug; sulforaphane is naturally found in our diet.

The team will next test whether sulforaphane can stimulate the proper keratin protein in the appropriate subset of human skin cells a vital matter for any future medical hopes. Beyond that are issues of how effective a topical application would be on human skin, which is considerably thicker than mouse skin, as well as examining the long term effects of sulforaphane treatment.

If we can clear these important hurdles, then sulforaphane can potentially be a tremendous therapeutic, with the added benefit of having anticancer properties, Coulombe says. And when you consider that the only current option for EBS is wrapping gauze around trauma-prone areas to minimize breakage, and otherwise avoiding infection and making sure blisters heal properly, then even a mild success would be a significant benefit for these patients.


'/>"/>

Contact: Nick Zagorski
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. UCSD discovery may help extend life of natural pesticide
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. UCLA scientists store materials in cells natural vaults
6. Man-made wetlands effectiveness similar to natural marsh
7. Natural Killers Could Lead to New Hepatitis Treatments
8. Researchers pioneer new gene therapy technique using natural repair process
9. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Naturally occurring asbestos linked to lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... City of Entiat on Tuesday, July 8, 2014. Despite ... to over 1,000 acres by evening. Three outbuildings were ... by the Washington Department of Natural Resources. The ... developing fire control strategies and tactics. Other cooperators include ... Natural Resources, (WA DNR), Bureau of Land Management, Chelan ...
(Date:7/11/2014)... of Standards and Technology (NIST) need a special ... often prove that necessity is truly the mother ... M. Lorna De Leoz and Stephen Stein, NIST ... Glycomics is the study of the abundant, often-branched ... proteins and lipids and influence cellular processes, including ...
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... exposed to low doses of atrazine, a widely used herbicide, ... through puberty later than non-exposed animals. The research adds to ... used to control weeds and grasses in crops such as ... to be relatively persistent in the environment, potentially finding their ...
... current issue of Deutsches rzteblatt International (Dtsch ... pharmacologist, and coauthors present the PRISCUS List: a list ... effects when given to elderly patients. The authors ... Germany in the setting of a joint project entitled ...
... Chinese on EurekAlert! Chinese . ... Medicine, Hershey, Pennsylvania have discovered that the Opioid Growth ... important system with potent antitumor properties, has controlled entry ... passage of OGF-OGFr is critical to cell proliferation and ...
Cached Biology News:Atrazine causes prostate inflammation in male rats and delays puberty 2Regulation of cell proliferation is dependent on nucleocytoplasmic trafficking 2Regulation of cell proliferation is dependent on nucleocytoplasmic trafficking 3
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
(Date:7/10/2014)... --  Ceres, Inc . (Nasdaq: CERE ), ... results for the three months ended May 31, 2014 ... Ceres reported that the company and its customers have ... in Brazil, which concluded in June, despite dry and ... for part of the growing season. Yields of several ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2
... 15 3SBio Inc. (Nasdaq:,SSRX), a leading China-based ... biopharmaceutical products, today,announced the results of the shareholder ... held on September 12, 2008 (Friday) at 10:00 ... shareholders re-elected Dr. Jing Lou,Liping Xu, Bin Huang, ...
... Plans to Phase in Routine Vaccination Program ... and Young Children -, COLLEGEVILLE, Pa., Sept. ... WYE ), today announced that,South Africa has ... (Pneumococcal Saccharide Conjugated Vaccine,Adsorbed), a vaccine which helps ...
... Biopharma,Inc. (OTC Bulletin Board: CBPC) announced today that it ... of Delaware an amendment to its Certificate,of Incorporation to ... common stock ("Common Stock") will begin trading on a,reverse-split ... CHBO., By unanimous written consent dated July 3, ...
Cached Biology Technology:South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 2South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 3South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 4China Biopharma Effects 1 for 100 Reverse Stock Split 2China Biopharma Effects 1 for 100 Reverse Stock Split 3