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Natural S-Equol suggested as critical component in SE5-OH for reducing menopausal hot flushes
Date:4/30/2010

per milliliter (ml) of plasma respectively at the end of the study. Rats receiving conjugated estrogen drug or placebo after sham surgery had respective E2 levels of 4,016 and 44 ng/ml, both significantly different from the rats who received placebo after ovary-removal surgery, P<0.05 for both. FSH measures were 0.93, 0.91 and 0.81 ng/ml for rats receiving, respectively, SE5-OH containing Natural S-equol, purified Natural S-equol or placebo after ovary-removal surgery. Rats receiving conjugated estrogen drug, or placebo after sham surgery, had respective FSH levels of 0.39 and 0.04 ng/ml, both significantly different from rats who received placebo after ovary-removal surgery, p<0.05 for both.

The average weight of the rats' uteruses did not differ between those who received SE5-OH containing Natural S-equol or purified Natural S-equol, 0.13 and 0.14 grams, respectively. The average weight of the rats receiving placebo after ovary-removal surgery was 0.12 grams. In contrast, rats receiving conjugated estrogen drug had dramatically greater average uterine weights due to its estrogenic effects, 0.61grams. The rats receiving placebo after sham surgery also had larger average uterine weights, 0.55 grams.

How SE5-OH is made

SE5-OH for the study was created under current Good Manufacturing Practices using the equol-producing lactic acid bacterial strain Lactococcus 20-92 in a patented and proprietary process by the Otsuka Pharmaceutical Co., Ltd. The patented fermentation process converts daidzein, a naturally occurring compound in soy germ, to Natural S-equol, steadily increasing the concentration of Natural S-equol until reaching a maximum concentration at 72 to 96 hours and decreasing daidzein by 95 percent. Following fermentation, the SE5-OH powder undergoes a sterilization process using heat denaturation that deactivates the bacteria. The process is designed to produce a product rich in Natural S-equol that can be used as a nut
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Contact: Stephen McCauley
SMcCauley@porternovelli.com
202-973-3615
Porter Novelli
Source:Eurekalert

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