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Natural S-Equol suggested as critical component in SE5-OH for reducing menopausal hot flushes
Date:4/30/2010

study, rats underwent TST measures prior to ovary-removal or the sham surgery and then at weeks three, four and five after surgery during the treatment period. The average TST of a female rat is about 27 degrees Celsius (C), (about 80.6 degrees Fahrenheit). After ovary-removal surgery, the average TST increases for approximately seven weeks, resembling the human symptoms of hot flushes that temporarily occur after estrogen withdrawal because of menopause, and then cease with the time. A hot flush includes an intense sensation of heat along with the body's activation of ways to dissipate heat, including the dilatation of skin blood vessels and sweating.

Daily doses of SE5-OH containing 11.7 milligrams (mg) per kilogram(kg) of body weight of Natural S-equol and of 11.7 mg/kg purified Natural S-equol were equally effective in suppressing the elevation of TST induced by the ovary-removal surgery. Both groups of rats had average TSTs significant below that of the rats receiving ovary-removal surgery and placebo, (27.1, 27.1 and 27.5 C, respectively at week three, P<0.05). Also, the rats receiving the conjugated estrogen drug as well as rats receiving placebo after sham surgery had significant suppression of average TST compared to that of rats receiving a placebo after ovary-removal surgery, (26.6, 26.9 and 27.5 C, respectively at week three, P<0.05). The significant differences in average TSTs between groups also occurred at weeks four and five.

SE5-OH containing Natural S-equol and purified Natural S-equol had no effects on the average levels of the two reproductive hormones E2 and FSH. E2 is the primary naturally occurring estrogen in women and is formed primarily in the ovary. FSH stimulates production of eggs and E2 during the first half of the menstrual cycle. Specifically, the rats receiving SE5-OH containing Natural S-equol, purified Natural S-equol and placebo after ovary-removal surgery had E2 levels of 14, 12 and 11 nanograms (ng)
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Contact: Stephen McCauley
SMcCauley@porternovelli.com
202-973-3615
Porter Novelli
Source:Eurekalert

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