Natural S-Equol in SE5-OH thought to be a critical component in reducing hot flushes
Investigators consider Natural S-Equol in SE5-OH to be the primary component in SE5-OH to reduce hot flushes based on measurement of modeled hot flushes in an animal study. The study also measured two reproductive hormones, estradiol (E2) and follicle stimulating hormone (FSH), as well as uterine weight in healthy female rats from which the ovaries had been surgically removed to simulate menopause and those that underwent a sham surgery, in which their ovaries were not removed, to account for the effects from the stress of the surgery. Treatments included SE5-OH containing Natural S-equol, purified Natural S-equol, a placebo and a conjugated estrogen, a drug approved by the U.S. Food and Drug Administration for the treatment of moderate to severe vasomotor symptoms due to menopause. Animal menopause studies commonly use conjugated estrogen as a comparison treatment to examine the efficacy of new potential treatments for the reduction of menopausal symptoms including hot flushes. All treatments began three days after the rats' surgery and lasted for 38 days.
The study used a recognized validated animal model that simulates hot flush symptoms women can experience during menopause and post-menopause. The animal model involves measuring changes in the average temperatures of the rats' tails, known as tail skin temperature (TST). In the
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