Anaheim, Calif. (April 30, 2010) Natural S-equol, a novel soy germ-based compound, is very likely the primary ingredient for reducing hot flushes in the dietary supplement SE5-OH, which is under development for reduction of menopause symptoms, according to pre-clinical efficacy data from studies using an animal model presented at the Experimental Biology (EB) 2010 annual meeting. SE5-OH is in advanced studies in menopausal women, and peer-reviewed reports have previously documented that postmenopausal Japanese women receiving SE5-OH containing Natural S-equol significantly reduced the frequency of their hot flushes compared to women in the same study receiving a placebo (P=0.0092).
"Recent clinical trials have documented the benefits of SE5-OH containing Natural S-equol for relief of hot flushes in U.S. and Japanese women. SE5-OH containing Natural S-equol is made by the fermentation of soy, and our new data strongly suggest that it is the Natural S-equol in SE5-OH that may be responsible for the beneficial effects on menopausal symptoms," said Belinda H. Jenks, Ph.D., director of Scientific Affairs & Nutrition Education at Pharmavite LLC.
Pharmavite LLC, the makers of NatureMade vitamins and minerals and a subsidiary of Otsuka Pharmaceutical Co., Ltd., is studying in clinical trials SE5-OH containing Natural S-equol in supplement form for the management of menopausal symptoms. Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd. developed the ingredient and has an ongoing research program to study SE5-OH containing Natural S-equol. Otsuka Pharmaceutical Co., Ltd., supported the research and data presented at the Experimental Biology annual meeting, and complete reports of the data from the study will be submitted for peer-review publication.
Soybeans contain a naturally occurring compound called daidzein that certain bacteria living within the human digestive tract can metabolize, or convert, into S-equol [7
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