Navigation Links
Native American ancestry linked to greater risk of relapse in young leukemia patients
Date:2/6/2011

The first genome-wide study to demonstrate an inherited genetic basis for racial and ethnic disparities in cancer survival linked Native American ancestry with an increased risk of relapse in young leukemia patients. The work was done by investigators at St. Jude Children's Research Hospital and the Children's Oncology Group (COG).

Along with identifying Native American ancestry as a potential new marker of poor treatment outcome, researchers reported evidence the added risk could be eliminated by administering an extra phase of chemotherapy. The study involved 2,534 children and adolescents battling acute lymphoblastic leukemia (ALL), the most common childhood cancer. The work appears in the February 6 advance online edition of the scientific journal Nature Genetics.

The children were all treated in protocols conducted by St. Jude or COG. Although the overall cure rate for childhood ALL now tops 80 percent, and is close to 90 percent at St. Jude, racial and ethnic disparities have persisted. Based on self-declared status, African-American and Hispanic children with the disease have often fared worse than their white and Asian counterparts. This is the first study to use genomics to define ancestry, rather than relying on self-declared racial or ethnic categories.

"To overcome racial disparity you have to understand the reasons behind it," said Jun Yang, Ph.D., St. Jude Department of Pharmaceutical Sciences assistant member and the study's first author. "While genetic ancestry may not completely explain the racial differences in relapse risk or response to treatment, this study clearly shows for the first time that it is a very important contributing factor."

This study identified a possible mechanism linking ancestry and relapse. Hispanic patients, who have a high percentage of Native American ancestry, were more likely than other patients to carry a version of the PDE4B gene that was also strongly associated with rel
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-297-9861
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Neiker-Tecnalia creates air-conditioned greenhouse with alternative energies
2. Home and away: How do invasive plant species dominate native species?
3. ONR, Marine Corps show alternative energy use at forward operating bases can save dollars, lives
4. The world can be powered by alternative energy, using todays technology, in 20-40 years
5. Virginia Tech engineers introduce thermotherapy as a chemotherapy alternative
6. Electricity collected from the air could become the newest alternative energy source
7. College students want more information about native wildflowers
8. Potomac River: 10-fold increase in native submerged vegetation reflects improved water quality
9. Is organic farming good for wildlife? It depends on the alternative
10. Trojan Horse attack on native lupine
11. Native-like spider silk produced in metabolically engineered bacterium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014  The 2014 Holiday Season may be the ... Intelligence reports that the long anticipated floodgates for consumer ... demand for smart phones, tablets, and wearable mobile devices ... 2.5 billion users with nearly 4.8 billion biometric devices ...
(Date:12/17/2014)... DUBLIN , Dec. 15, 2014 Research and Markets ... of the "Samsung Galaxy S5 - Home Button ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first time ...
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the travel experience ... borders. Over the past decade, ePassports, biometric readers, and ... process through border control via eGates and Automated Passport ... seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... (UM) Rosenstiel School of Marine & Atmospheric Science Professors Shuyi ... Fellows of the American Meteorological Society (AMS), the nation,s leading ... Dr. Bruce Albrecht, who is a Fellow of the ... Award. The honor of Fellow is given to ...
... announced the 12 projects funded in a fourth ... (PIRE) awards. Many of these projects engage scientists ... energy alternatives, as the need for solutions challenges ... Agency for International Development (USAID) today also announced ...
... Texas at Austin have discovered that the lack of a ... neural tube birth defects in developing embryos. It ... dramatically reduces the incidence of neural tube defects, such as ... birth defects. In some populations, folic acid supplementation has decreased ...
Cached Biology News:Univ. of Miami profs Chen and Soden named Fellows of AMS, Albrecht receives AMS Teaching Award 2Univ. of Miami profs Chen and Soden named Fellows of AMS, Albrecht receives AMS Teaching Award 3NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 2NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 3NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 4NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 5NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 6NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 7NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 8NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 9NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 10NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability 11Lack of key enzyme in the metabolism of folic acid leads to birth defects 2
(Date:1/22/2015)... (PRWEB) January 22, 2015 Diagenode, ... such as the Bioruptor® and complete solutions for ... for chromatin immunoprecipitation, alleviating the need for manual ... controls needed for ChIP of histones or transcription ...
(Date:1/22/2015)... 2015   Cypher Genomics, Inc., the leading ... SQNM ), the leading molecular diagnostics company, ... noninvasive prenatal tests (NIPT). Through this agreement, Sequenom ... to advance analysis of clinically-relevant fetal sub-chromosomal variants ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 The report ... by Product Type & Provider Type - Global Advancements, ... market with an in-depth analysis and forecasting of revenues. ... spread through 221 pages and in-depth TOC on “Service ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... endured a hard struggle, and somehow survived where other ... same sites and domain names must face harsher realities ... Today without visibility, on e-commerce, Web sites are simply ... the right match, they only clash into the billions ...
... is leading the blog tools market space, has all the ... founders - husband-and-wife team of Ben and Mena Trott - ... and created Moveable Type, arguably the best and most widely ... company name represents the number of days between their birth ...
... agricultural and lawn care pesticides may cause injury to ... to a study conducted by researchers at ... in the May 2004 issue of Environmental Health ... Environmental Health Sciences, National Institutes of Health. , ,In ...
Cached Biology Technology:The mysteries and the future of Web sites 2The mysteries and the future of Web sites 3The mysteries and the future of Web sites 4Six Apart hits its adolescence 2Six Apart hits its adolescence 3Six Apart hits its adolescence 4Six Apart hits its adolescence 5Infertility linked to lawn chemicals by Marshfield Clinic researcher 2
... multicolor analysis in a modern flow cytometer, ... that are differentially labeled with fluorescent probes. ... typically used for cell labeling are broader ... a flow cytometers filters. Thus, the fluorescence ...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: rack ...
... ActiveSight, the leading provider of ... design, offers fragment-based screening services to ... screening involves the binding of drug-like ... crystallized protein drug targets, allowing scientists ...
...
Biology Products: