Navigation Links
National asthma genetics consortium releases first results
Date:7/31/2011

-Caribbeans. The polymorphism, located in a gene called PYHIN1, was not present in European-Americans and may be the first asthma susceptibility gene variant specific to populations of African descent.

Four more gene variants were found significant for asthma risk by the meta-analysis: the 17q21 locus, and IL1RL1, TSLP, and IL33 genes. All four of these sites were concurrently identified in a separate dataset by the GABRIEL Study of more than 40,000 European asthma cases published last year in the New England Journal of Medicine. Confirming these associations in the more diverse EVE population offers additional evidence that the gene variants are significant across ethnicities, the researchers reported.

"We were able to show that almost all of the genes other than PYHIN1 are trans-ethnic and important in all of the groups," Ober said.

The Nature Genetics study is only the first fruit of the EVE Consortium mission to understand the genetics of asthma. A deeper meta-analysis looking at a longer list of gene variants is currently underway, and individual groups within the consortium are using the pooled dataset to answer additional questions. Topics of interest include gene-environment interactions, genetic associations with asthma-associated phenotypes such as allergies and lung function, and the role of tissue-specific gene expression.

"What you see here in this paper is only the beginning," Nicolae said. "The foundation was to make people work together, share the data, and share research ideas, and that will generate a lot of research down the road."


'/>"/>

Contact: Robert Mitchum
robert.mitchum@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BIO-key(R) International To Exhibit at Oracle OpenWorld
2. Sentara begins international trial -- open at only 24 US locations
3. UW science photo takes second in national contest
4. Rice University establishes National Corrosion Center
5. 8 National Medals of Science awardees to be honored at gala, then the White House
6. Perinatal Days and International Stillbirth Conference -- Nov.5-7
7. AVS 55th International Symposium & Exhibition, Oct. 19-24
8. Childrens National researchers develop novel anti-tumor vaccine
9. National Science Foundation grants Clemson professors award to develop nanoprobes
10. National Science Foundation grant expands UMCES oyster research
11. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... , May 20, 2015 NXT-ID, Inc. (NASDAQ: ... its wholly owned subsidiary, 3D-ID LLC, a company engaged ... Battelle for the biometrics technology portion of the recently ... from the Department of the Army. 3D-ID ... developed for government, law enforcement and security agencies. ...
(Date:5/18/2015)... May 18, 2015 Fingerprint Cards (FPC) ... FPC1025, FPC1145, FPC1155 and FPC1035 from one if its module ... and including Q3 2015 and the sensors will be used ... order values for 2015 hereby amount to 740 MSEK to ... of 140 MSEK and a number of smaller orders not ...
(Date:5/11/2015)... , May 11, 2015  Through a well-rounded UAS ... had a strong showing at AUVSI,s Unmanned 2015 ... representatives of Ohio,s UAS industry met ... abroad from all points along the UAS ecosystem. ... Coalition,s (DDC) Vice President for Aerospace Rich Knoll . ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... Palo Alto, CA Researchers at the Carnegie Institution,s ... link in the so-called signaling pathway for plant steroid ... molecules that start at the cell surface and cascade ... the first such pathway in plants for which all ...
... for many a person this is the greatest of pleasures. ... we drink beer as it is among the most energy-intensive ... (TUM) are working hard to improve the energy balance of ... combination that would allow energy savings of up to 20% ...
... periodontitis, a form of gum disease, is an independent ... This suggests the need for increased efforts to prevent ... the risk of this form of cancer. "Prevent ... maintain good oral hygiene," said Mine Tezal, D.D.S., Ph.D., ...
Cached Biology News:Plants on steroids: Key missing link discovered 2Environmentally 'green' beer: Munich brewing engineers research energy savings 2Environmentally 'green' beer: Munich brewing engineers research energy savings 3Prevent periodontitis to reduce the risk of head and neck cancer 2
(Date:5/21/2015)... 21, 2015 /PRNewswire/ - RepliCel Life Sciences Inc. ... medicine company focused on the development of autologous ... at the International Society for Cellular Therapy (ISCT) ... tendinosis currently in a Phase 1/2 clinical trial.  ... from 5:30 PM to 7:00 PM local ...
(Date:5/21/2015)... 2015 Tunnell Consulting, Inc. ... as senior statistician and Principal, a position to which ... the management and analysis of complex and large data ... , “We’re delighted to have Julia join the Tunnell ... said Dr. Philippe Cini, Group Vice President and leader ...
(Date:5/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ) ... in HW_Technical Insights" report to their offering. ... trends in the Health and Wellness sector and has ... an impact in the year 2015. The research service ... health and wellness technologies that are anticipated to have ...
(Date:5/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ) ... Therapy Market Outlook 2020 " report to their ... and regenerative medicine is expected to have huge marketing ... help in the growth of deregulated organs. Several therapeutic ... unable to form new tissue or sometimes organ transplant ...
Breaking Biology Technology:RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Top Technologies in the Health and Wellness Industry 2015 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... Acquisition Expected to Add New Drug Products to Aida Pharmaceuticals, ... ... MONICA, Calif., March 27 Aida,Pharmaceuticals, Inc. (OTC Bulletin Board: ... to acquire a controlling interest,in one of the leading microbiology ...
... Pharmasset, Inc.,(Nasdaq: VRUS ), a pharmaceutical company ... treat viral infections, is,pleased to announce the appointment ... the,Board of Directors and the Nominating and Corporate ... the Board of Directors of Sapphire,Therapeutics, a Director ...
... Led by OrbiMed Advisors, World,s Largest Healthcare ... ... a,bio-pharmaceutical company developing Anticalins(R), a novel class of,targeted human protein therapeutics, ... by new investor OrbiMed Advisors LLC, a major global fund dedicated,to ...
Cached Biology Technology:Aida Pharmaceuticals, Inc. Acquires High-Level Research Institute in the People's Republic of China 2Aida Pharmaceuticals, Inc. Acquires High-Level Research Institute in the People's Republic of China 3Pharmasset Appoints Herbert J. Conrad as a Director 2Pharmasset Appoints Herbert J. Conrad as a Director 3Pieris Raises EUR 25 M (US$ 38 M) in Series B Financing Round 2Pieris Raises EUR 25 M (US$ 38 M) in Series B Financing Round 3Pieris Raises EUR 25 M (US$ 38 M) in Series B Financing Round 4
Mouse IL-31 RA Biotinylated Affinity Purified PAb...
Sf21 cells derived from Spodoptera frugiperda ovarian cells are recommended for high-level production of recombinant proteins. Higher expression levels of some proteins are seen due to the larger ce...
... universal lysis buffer, PCR mix, DNA polymerase ... l volume PCR reactions. This system can ... positive rod and coccus bacteria, such as ... Aureus, Streptococcus Agalactiae, and etc. With the ...
...
Biology Products: