Navigation Links
National asthma genetics consortium releases first results
Date:7/31/2011

enrolled in a study. To find variants involved in complex diseases, thousands of participants may be necessary a logistical and financial demand often beyond the capacity of an individual research team.

"It has become clear to geneticists studying nearly every common disease that GWAS are often under-powered, and unless you pull together many researchers doing the same thing you're just not going to have the power to find genes," said Dan Nicolae, PhD, associate professor of medicine, statistics, and human genetics at University of Chicago, co-chair of the consortium and another senior author of the study. "That was the motivation for nine groups of investigators coming together to form EVE."

Spurred by support from the NHLBI and the National Institutes of Health, research groups from the nine institutions discussed pooling their GWAS data to create a larger, shared dataset. But it wasn't until they received a $5.6 million grant from the American Recovery and Reinvestment Act of 2009 that the EVE Consortium could officially form and hire the necessary personnel to execute the collaboration.

"It would never have been possible without the grant, this was a huge amount of work," said Nicolae, "The key was the ARRA funding that allowed us to move it faster."

In addition to increased power to find variants associated with asthma risk, the EVE dataset comprised a more ethnically diverse population than similar efforts in other countries by including European Americans, African Americans/African Caribbeans, and Latinos.

"We believe that this heterogeneity is important," Ober said. "There are differences in asthma prevalence in these three groups, so it's important to understand whether these are caused by environmental exposures or by differences in genetic risk factors."

The diverse sample enabled the researchers to discover a novel genetic association with asthma observed exclusively in African-Americans and African
'/>"/>

Contact: Robert Mitchum
robert.mitchum@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. BIO-key(R) International To Exhibit at Oracle OpenWorld
2. Sentara begins international trial -- open at only 24 US locations
3. UW science photo takes second in national contest
4. Rice University establishes National Corrosion Center
5. 8 National Medals of Science awardees to be honored at gala, then the White House
6. Perinatal Days and International Stillbirth Conference -- Nov.5-7
7. AVS 55th International Symposium & Exhibition, Oct. 19-24
8. Childrens National researchers develop novel anti-tumor vaccine
9. National Science Foundation grants Clemson professors award to develop nanoprobes
10. National Science Foundation grant expands UMCES oyster research
11. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... predict the stability of today,s largest ice sheets in Greenland ... years ago, for example when Earth was going through ... a high sea level due to ice sheet collapse at ... that if the world,s largest ice sheets collapsed in the ... modern, progressively warming world. , However, a new groundbreaking ...
(Date:5/16/2013)... Why do so many sports players and athletes choose ... new study to be published in Psychological Science ... suggests that it may have to do with their ... scientist Daniel Farrelly of the University of Sunderland and ... color in a competitive task had higher testosterone levels ...
(Date:5/16/2013)... (GWA), where the entirety of an individual,s DNA is ... which can cause health problems is a massively useful ... pose major ethical problems if used incorrectly, say new ... published on line today (16 May 2013) in the ... based on whole genome and on exome* sequencing and ...
Breaking Biology News(10 mins):World's biggest ice sheets likely more stable than previously believed 2High-testosterone competitors more likely to choose red 2European Society of Human Genetics urges caution over use of new genetic sequencing techniques 2
... Capuchin monkeys are playful, inquisitive primates known for their ... New research now shows that just like humans, they ... the brain, specifically in the corpus callosum, the region ... A recently published paper by Associate Professor of Psychology ...
... hepatitis C virus (HCV). The outcome of HCV infections is ... chronic infections will develop into liver cirrhosis or liver cancer. ... is there any approved vaccine for this virus, hepatitis C ... fifty percent of HCV infected patients recovers spontaneously. The hepatitis ...
... test before taking the cancer drug irinotecan, and the ... guidelines to say so, according to researchers at the ... also known by its brand name Camptosar, is used ... FDA recommends screening patients for a gene that could ...
Cached Biology News:Influence of sex and handedness on brain is similar in capuchin monkeys and humans 2Who will recover spontaneously from hepatitis C virus infection 2UNC study questions FDA genetic-screening guidelines for cancer drug 2
(Date:5/20/2013)... 20, 2013 On 25-28 July, 2013, ... in Paris - the beautiful city of lights. , ... Medicine is revolutionizing the medical world. Understanding and integrating ... the hallmark of this transformation. Much of the present ... the epidemiologic studies of large cohorts that do not ...
(Date:5/20/2013)... Kitware, a leader in data visualization, ... the exploration of hospital costs across the United ... the recent release of “Medicare Provider Charge Data,” a ... procedures from the Centers for Medicare & Medicaid Services. ... at hospitals across the country has sparked considerable controversy; ...
(Date:5/20/2013)... May 20, 2013 In Early 2013, ... field of biotoxin related illnesses , announced his vision ... able to advance his protocol for treating Chronic Inflammatory ... the third physician to achieve certification in the Shoemaker ... able to practice the Shoemaker Protocol in other parts ...
(Date:5/20/2013)... City, CA (PRWEB) May 20, 2013 ... has announced the appointment of Lisa Baird as Executive ... on July 8, 2013. The WMIS vision ... imaging applications to understand and effectively treat diseases in ... Imaging Society (WMIS) was established in 2011 by integrating ...
Breaking Biology Technology:The International Congress on Personalized Medicine - Up Close and Personalized 2013 in Paris 2Kitware Enables Interactive Exploration of CMS Medicare Data 2Dr. Ritchie Shoemaker Certifies Third Physician in His Treatment Protocol for Chronic Inflammatory Response Syndrome (CIRS) 2WMIS Appoints Lisa Baird as Next Executive Director 2
... , COLUMBIA, Md., Sept. 2 ACell, ... Global Investment Conference. , , The conference ... the New York Palace Hotel in New York City. James DeFrancesco, ... presentation on September 11th beginning at 9:10 AM (EDT) in the ...
... , HAYWARD, Calif., Sept. 2 ... completed the second closing of its Series A equity financing ... round to $5.4 million. , , ACD ... proprietary diagnostic tests based on the company,s patent pending RNAscope(TM) ...
... , , , INDIANAPOLIS, ... company, today announced that, effective October 1, 2009, it would ... cents per kg for all non-contract customers or as existing ... continue to invest in expanding global supply for the high ...
Cached Biology Technology:ACell's CEO to Present at Rodman & Renshaw's 2009 Annual Global Investment Conference 2ACD Completes the Second Closing of Series A Financing and Initiates Services for Biomarker Validation and Companion Diagnostic Development 2
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details....
75 x 25 mm; sterile, recommended for immunohistochemistry of cell lines growing in suspension, Poly-D-Lysine coated, glass slides with polystyrene vessel, lid and safety removal tool...
GOAT ANTI CARICA PAPAYA PAPAIN...
... use with T4 Polynucleotide Kinase for ... ends) of nucleic acids. In the ... the 5' phosphate group from DNA ... Gamma-phosphate of ATP to the free ...
Biology Products: