Navigation Links
National Institutes of Health to fund research probing proteins linked to cancer, diabetes

Researchers from the Polytechnic Institute of New York University (NYU-Poly) and NYU have received a grant from the National Institutes of Health (NIH) to further a novel approach to understanding the genetic underpinnings of diseases including cancer and diabetes.

Jin Kim Montclare, associate professor of chemical and molecular engineering at NYU-Poly, and Yingkai Zhang, associate professor of chemistry at NYU, have teamed to study the functioning of one of the key proteins in human DNA, called histone. Histones are scaffolding proteins that organize DNA within the cell nucleus, and they are subject to modifications by enzymes that affect gene expression, both in health and disease.

Zhang and Montclare are combining their expertise in computational chemistry and protein engineering, respectively, to shed new light on one of the key enzymes that modify histones, histone acetyltransferases (HATs).

"HATs play an essential role in gene regulation, and while we know that aberrant or mutated HATs are associated with diseases like cancer and diabetes, we don't understand their precise catalytic mechanisms," explained Montclare. "If we can understand the processes by which these proteins can modify histones and how mutations can lead to disease, we move closer to creating targeted therapies to prevent or reverse these changes."

The researchers' collaborative approach is unique, and has not been explored for HATs. Zhang will create a computational study of the mechanics of HATs, offering what may be the most detailed picture of their workings. This sets the stage for Montclare's work, of engineering and testing the HATs and designed variants for reactivity on histones.

"Bringing computational powers to bear on these processes will not only elucidate the underpinnings of the enzymes as they exist now, but will allow us to run simulations to test the impact of modifications and therapies to reverse the kinds of changes linked to disease," Zhang said.

The National Institutes of Health grant will provide $1.2 million over four years.


Contact: Kathleen Hamilton
Polytechnic Institute of New York University

Related biology news :

1. PETA International Science Consortium disappointed in denial of Dow appeal
2. First international collaboration to showcase latest body of evidence of dairy health benefits
3. SPIE on global team proposing International Year of Light at United Nations
4. CLEO: 2013 -- the Premier International Laser and Electro-Optics Event in San Jose next week
5. The German National Academy of Sciences Leopoldina makes recommendations for the G8 summit
6. CARE Pharmacies Joins National Association of Specialty Pharmacy (NASP) as a Founding Corporate Member
7. Save the date: American Chemical Society National Meeting, Sept. 8-12, 2013, in Indianapolis
8. 2 UCLA faculty elected to National Academy of Sciences
9. Ophthalmologist Inventors of Human Identification Technology Inducted into National Inventors Hall of Fame
10. New National Inventors Hall of Fame inductees received vital NSF support
11. Freeman elected to National Academy of Science
Post Your Comments:
(Date:10/29/2015)... BOSTON , Oct. 29, 2015  Connected health ... phenomena driving the explosion of technology-enabled health and wellness, ... his new book, The Internet of Healthy ... apps, sensors or smartphones even existed, Dr. Kvedar, vice ... model of health care delivery, moving care from the ...
(Date:10/27/2015)... , October 27, 2015 ... Semantic Gaze Mapping technology (ASGM) automatically maps data from ... Tracking Glasses , so that they can be ... --> Munich, Germany , October 28-29, ... maps data from mobile eye tracking videos created with ...
(Date:10/26/2015)... 2015  Delta ID Inc., a company focused on ... PC devices, announced its ActiveIRIS® technology powers the iris ... launched by NTT DOCOMO, INC in Japan ... smartphone to include iris recognition technology, after a very ... in May 2015, world,s first smartphone to have this ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... International Society ... one of the premier annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The ... where ISPE hosted the largest number of attendees in more than a decade. ...
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model ... Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent the First–Person View ... years. Many AMA members have embraced this type of racing and several new model ...
(Date:11/24/2015)... Nov. 24, 2015  Twist Bioscience, a company ... Leproust, Ph.D., Twist Bioscience chief executive officer, will ... on December 1, 2015 at 3:10 p.m. Eastern ... City. --> --> ... Twist Bioscience is on Twitter. Sign up to ...
(Date:11/24/2015)... LOS ANGELES , Nov. 24, 2015 ... a biotechnology company focused on the discovery, development and ... Marban , Ph.D., Chief Executive Officer, is scheduled to ... December 1, 2015 at 10:50 a.m. EST, at The ... York City . . ...
Breaking Biology Technology: