Navigation Links
National Institutes of Health to fund research probing proteins linked to cancer, diabetes
Date:6/20/2013

Researchers from the Polytechnic Institute of New York University (NYU-Poly) and NYU have received a grant from the National Institutes of Health (NIH) to further a novel approach to understanding the genetic underpinnings of diseases including cancer and diabetes.

Jin Kim Montclare, associate professor of chemical and molecular engineering at NYU-Poly, and Yingkai Zhang, associate professor of chemistry at NYU, have teamed to study the functioning of one of the key proteins in human DNA, called histone. Histones are scaffolding proteins that organize DNA within the cell nucleus, and they are subject to modifications by enzymes that affect gene expression, both in health and disease.

Zhang and Montclare are combining their expertise in computational chemistry and protein engineering, respectively, to shed new light on one of the key enzymes that modify histones, histone acetyltransferases (HATs).

"HATs play an essential role in gene regulation, and while we know that aberrant or mutated HATs are associated with diseases like cancer and diabetes, we don't understand their precise catalytic mechanisms," explained Montclare. "If we can understand the processes by which these proteins can modify histones and how mutations can lead to disease, we move closer to creating targeted therapies to prevent or reverse these changes."

The researchers' collaborative approach is unique, and has not been explored for HATs. Zhang will create a computational study of the mechanics of HATs, offering what may be the most detailed picture of their workings. This sets the stage for Montclare's work, of engineering and testing the HATs and designed variants for reactivity on histones.

"Bringing computational powers to bear on these processes will not only elucidate the underpinnings of the enzymes as they exist now, but will allow us to run simulations to test the impact of modifications and therapies to reverse the kinds of changes linked to disease," Zhang said.

The National Institutes of Health grant will provide $1.2 million over four years.


'/>"/>

Contact: Kathleen Hamilton
hamilton@poly.edu
718-260-3792
Polytechnic Institute of New York University
Source:Eurekalert

Related biology news :

1. PETA International Science Consortium disappointed in denial of Dow appeal
2. First international collaboration to showcase latest body of evidence of dairy health benefits
3. SPIE on global team proposing International Year of Light at United Nations
4. CLEO: 2013 -- the Premier International Laser and Electro-Optics Event in San Jose next week
5. The German National Academy of Sciences Leopoldina makes recommendations for the G8 summit
6. CARE Pharmacies Joins National Association of Specialty Pharmacy (NASP) as a Founding Corporate Member
7. Save the date: American Chemical Society National Meeting, Sept. 8-12, 2013, in Indianapolis
8. 2 UCLA faculty elected to National Academy of Sciences
9. Ophthalmologist Inventors of Human Identification Technology Inducted into National Inventors Hall of Fame
10. New National Inventors Hall of Fame inductees received vital NSF support
11. Freeman elected to National Academy of Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers ... 5000 and the 6000i models are higher end machines that use the more unconventional ... spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci has ...
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
Breaking Biology Technology: