Navigation Links
National Institutes of Health award Williams professor $217,710 research grant

WILLIAMSTOWN, Mass., July 10, 2008 -- Thomas E. Smith, associate professor of chemistry at Williams College, has been awarded a $217,710 three-year grant by the National Cancer Institute of the National Institute of Health (NIH) for "Asymmetric Methods for the Synthesis of Pyran-Based Anticancer Natural Products."

"This research is concerned with the development of new methods that will allow for the efficient preparation of anticancer compounds," said Smith. He and his team will examine several natural products of promising medicinal value to formulate an efficient general strategy for the asymmetric synthesis of these types of complex molecular architectures.

The molecules that will be examined are acutphycin, which inhibits the growth of malignant cells; tedanolide C, which exhibits potent cytotoxicity against cancer cell lines; and other novel natural products of marine origin.

This study will build on Smith's earlier work on pyran-based products, which was funded by a 2003 National Science Foundation (NSF) grant. Chiral pyran-based ring systems (six-membered rings composed of carbon and oxygen atoms) are found in numerous biologically relevant natural product classes.

At Williams since 1998, Smith teaches courses on the evolution and operation of human medicines, synthetic organic chemistry, and introductory organic chemistry. His research is concerned with organic synthesis and its applications in biology and pharmacology.

Smith's findings on organic synthesis appear in a number of chemistry journals and academic publications, most recently the Journal of Organic Chemistry, Organic Letters, and the Journal of Chemical Education.


Contact: Jo Procter
Williams College

Page: 1

Related biology news :

1. Wolves find happy hunting grounds in Yellowstone National Park
2. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
3. ESMO International Symposium on Immunology
4. Story tips from the US Department of Energys Oak Ridge National Laboratory, September 2007
5. Office of the Director of National Intelligence, CIO to Speak at Government Security Conference
6. Director of National Intelligence to Speak at Conference
7. Singapore National Science and Technology Awards
8. Conservation International and Toyota partner to protect Philippines rain forests
9. International team shows mercury concentrations in fish respond quickly to increased deposition
10. International team shows mercury concentrations in fish respond quickly to increased deposition
11. Office of the Director of National Intelligence, CIO to Speak at Government Security Conference
Post Your Comments:
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology ... drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription ... is able to cross the cell membrane and bind intracellular STAT3 and inhibit ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
(Date:10/10/2017)... 10, 2017 SomaGenics announced the receipt of ... develop RealSeq®-SC (Single Cell), expected to be the first ... (including microRNAs) from single cells using NGS methods. The ... to accelerate development of approaches to analyze the heterogeneity ... "New techniques for measuring levels of mRNAs in individual ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings ... mechanism by which its ProCell stem cell therapy ... limb ischemia.  The Company, demonstrated that treatment with ... of limbs saved as compared to standard bone ... molecule HGF resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology: