Navigation Links
National Heart Centre Singapore develops world's first human heart cell model
Date:10/25/2012

  • Heart cells from patients with inherited heart muscle disease can now be studied in a petri dish without risk to patients, including the possibility of testing new treatments
  • Experiments performed on the cells show that the heart cell model matches that of the clinical features of arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited heart muscle disease associated with sudden cardiac death
  • Landmark study published in European Heart Journal, a top ranking international peer reviewed journal

Researchers at the National Heart Centre Singapore (NHCS) have successfully created a human heart cell model of arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited heart muscle disorder which puts one at high risk of developing life-threatening arrhythmias and sudden cardiac death. The NHCS research team discovered that key characteristics of the disease, such as abnormal "fatty changes" and altered distribution of proteins involved in cell-cell connections (called desmosomal proteins) are reproduced in the heart cells. This novel cellular model for studying the disease could help to improve understanding on how these mutations lead to arrhythmias and clinical manifestations of ARVC. The study, the first of its kind in the world, was published in the European Heart Journal, a top ranking international peer-reviewed journal, in July 2012.

The human heart cell model was developed using patient-specific induced pluripotent stem cell (iPSC) technology which converts skin samples from an ARVC patient into heart muscle cells on a petri dish outside the body. This technique is based on the revolutionary iPSC technology of transforming skin cells into stem cells, developed by Professor Shinya Yamanaka, winner of the 2012 Nobel Prize in Physiology/Medicine. The NHCS research team has taken a step further by developing a key clinical application of the iPSC technology by replicating one's own hea
'/>"/>

Contact: Jessica Koh
jessica.koh.l.c@nhcs.com.sg
65-643-67924
SingHealth
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Story tips From the Department of Energys Oak Ridge National Laboratory, March 2012
2. Ultracold matter technology from CU and SRI International licensed to Boulders ColdQuanta
3. International Polar Year conference: From knowledge to action
4. ASBMB wins National Science Foundation grant to enhance K-12 science education
5. President, CEO Leppävuori, VTT: Finland should create a national bioeconomy strategy
6. Russia declares Land of the Leopard National Park
7. Large international study finds memory in adults impacted by versions of 4 genes
8. International team uncovers new genes that shape brain size, intelligence
9. As deadly cat disease spreads nationally, MU veterinarian finds effective treatment
10. Southampton researchers lead 2 international projects to help people out of poverty
11. Ohio state hosts national energy conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... 2014, Irvine, Calif. UC Irvine neurobiologists have found ... when transplanted into the brains of mice with the ... is published in the journal Stem Cells Research ... to work in two different mouse models. , ... dementia, is associated with accumulation of the protein amyloid-beta ...
(Date:4/15/2014)... know as early as 2020 how high sea levels ... team of researchers including Florida International University scientist Rene ... Science Foundation,s (NSF) Florida Coastal Everglades Long-Term Ecological Research ... in ecosystems from coral reefs to deserts, mountains to ... sea level rise is one of the most certain ...
(Date:4/15/2014)... at UC San Diego have succeeded in visualizing ... responsible for growth and resistance to drought. The ... to determine how the hormone helps plants respond ... the continuing increase in the atmosphere,s carbon dioxide, ... appears in the April 15 issue of the ...
Breaking Biology News(10 mins):UCI study finds modified stem cells offer potential pathway to treat Alzheimer's disease 2Long-term predictions for Miami sea level rise could be available relatively soon 2Biologists develop nanosensors to visualize movements and distribution of plant hormone 2
... insect brains, mouth bacteria behaving badly and the hundreds ... just some of the highlights at the Society for ... The annual event takes place on 6-9 September at ... international experts will present cutting-edge scientific research covering a ...
... Carolina State University shows that a species of shellfish widely ... actually increased in size, despite and possibly because of ... found indicates that human activity does not necessarily mean that ... species even a species that people relied on as ...
... filter-feeder, that anchors itself to the sea bed, offers new ... Ice Sheet a region that is thought to be ... for the Census of Antarctic Marine Life (CAML), scientists from ... coastal and deep sea regions around the continent and from ...
Cached Biology News:Archaeological study shows human activity may have boosted shellfish size 2Marine animals suggest evidence for a trans-Antarctic seaway 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Dyadic International, Inc. ("Dyadic") (OTC Pink: DYAI), a ... manufacture and sale of enzyme and protein products ... today announced financial results for the quarter ended ... this press release should be read in conjunction ...
... SynCo Bio Partners B.V., one of the leading GMP contract ... is again fully operational and SynCo has produced and released ... expansion of its Class A zone.   The ... in SynCo,s strategy in supporting its clients with new product ...
... for gram, novel carbon nanofiber-filled coatings devised by researchers ... and Texas A&M University outperformed conventional flame retardants used ... by at least 160 percent and perhaps by as ... reported in the journal Polymer ,* suggest that ...
Cached Biology Technology:Dyadic International Reports 2011 Second Quarter Financial Results 2Dyadic International Reports 2011 Second Quarter Financial Results 3Dyadic International Reports 2011 Second Quarter Financial Results 4Dyadic International Reports 2011 Second Quarter Financial Results 5Dyadic International Reports 2011 Second Quarter Financial Results 6Dyadic International Reports 2011 Second Quarter Financial Results 7SynCo Bio Partners Expands the Class A Zone in its Aseptic Filling Facility 2Novel coatings show great promise as flame retardants in polyurethane foam 2
Rabbit polyclonal to Phosphothreonine-X-Phosphotyrosine (HRP) ( Abpromise for all tested applications)....
Anti-ADAMTS-4, disintegrin-like domain Immunogen: Synthetic peptide - KLH conjugated Available Date: 38569...
Leucine-rich repeat-containing G-protein coupled receptor 4...
Mouse monoclonal [4i144] to HLA Class II DQ1 7 ( Abpromise for all tested applications). Antigen: Full length protein (Human): HLA Class 2 Antigen DQ1,7....
Biology Products: