Navigation Links
National Academy of Sciences honors geneticist and biologist Sue Biggins
Date:1/8/2013

SEATTLE Sue Biggins, Ph.D., a geneticist and biologist at Fred Hutchinson Cancer Research Center, has received the National Academy of Sciences Award in Molecular Biology. Sponsored by Pfizer Inc., the award consists of a $25,000 prize in recognition of a recent notable discovery by a young scientist.

She was among 18 honored by NAS this year for outstanding achievements in a wide range of fields spanning the physical, biological and social sciences.

Biggins, a member of the Fred Hutch Basic Sciences Division, was recognized for her work in understanding the mechanics of cell division. She recently made an important contribution to the field by figuring out how to isolate the specialized cellular machines known as kinetochores that allow cells to separate and accurately distribute their chromosomes.

For decades, researchers have tried and failed to isolate or assemble whole, functioning kinetochores to better understand how they help chromosomes separate and end up in the right daughter cells. If this goes awry, entire chromosomes are gained or lost, a hallmark of most cancers, birth defects and miscarriages.

Biggins' team, stepping away from genetic methods and borrowing from biochemists' playbook, for the first time succeed in separating the kinetochores from dividing yeast cells and studying them in test tubes.

During cell division, kinetochores act like handles on chromosomes and are under tremendous pressure as fibers pull on these handles to move the chromosomes within the dividing cell. If chromosomes fall off in the midst of this process, they don't end up in the daughter cell. Biggins and colleagues, in collaboration with the laboratory of Chip Asbury, Ph.D., in the Physiology and Biophysics Department at the University of Washington, found the harder the kinetochores are pulled, the harder they attach, like a finger-trap toy. This counterintuitive characteristic explains why the process works correctly so ofte
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. International study suggests human genes influence gut microbial composition
2. January 2013 story tips from Oak Ridge National Laboratory
3. President Obama honors MU researcher with National Medal of Science
4. Spanish consumers prefer national fish
5. Barbara Gilchrest named 2012 Charter Fellow by National Academy of Inventors
6. National Academy of Inventors names four UT Arlington professors as charter fellows
7. LSUHSCs Weiss chosen to help set national eye policy, research
8. U of M to lead international virtual institute studying climatic and human effects on Earth
9. International Drug & Explosives Detection Company IDenta Corp. Article to be Published by Zillion International
10. Elk bones tell stories of life, death, and habitat use at Yellowstone National Park
11. National Geographic unveils new phase of genographic project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... household and industrial products are in the environment – ... of them, scientists have yet to determine whether they ... toward doing that by estimating which substances people are ... in the ACS journal Environmental Science & Technology ... the risks to human health of any given substance ...
(Date:10/29/2014)... – As bodies decompose, their types and numbers ... they provide could mean the difference between a ... State University is using a more than $866,000 ... death-scene investigators examine these changing populations. The microbial ... location of death, gender, race, socioeconomic relations and ...
(Date:10/29/2014)... research potential of the Barcode of Life Data ... Biodiversity Data Journal (BDJ) used ... imported these into a human-readable text developed in manuscript ... were used to study the species distributions of ten ... , BOLD is originally designed to support the generation ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... and technical publishing business of John Wiley & Sons, Inc. ... Taipei have signed an agreement to closely cooperate and jointly ... The journal will be available online from volume 2011 in ... collections of online resources, used by 10 million people a ...
... Drying of northern wetlands has led to much more severe ... the atmosphere, according to new research led by a University ... Nature Communications , is the first to investigate the effect ... vulnerability of that carbon to burning. "Russia, Indonesia and ...
... by Dr. Jayne S. Weiss, Professor and Chair of Ophthalmology ... found that a defect in a gene involved in a ... of invasive bladder cancer. The findings are published in the ... Cell Biology . It is the featured research of the ...
Cached Biology News:Journal of the Chinese Chemical Society expands international reach with Wiley-VCH 2Drying intensifying wildfires, carbon release ninefold, study finds 2Mutation in gene associated with rare eye disease also contributes to bladder cancer growth 2
(Date:10/31/2014)... 31, 2014 Jeffrey T. Manuel, assistant ... Studies within the College of Arts and Sciences, is ... the history of alcohol-based fuels in Illinois. , ... have been working to build Illinois’ biofuels industry for ... aspect of the state's agricultural and business history. ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Brady ... identification solutions, today announced a new video testimonial ... labels. In the video, a research technician at the ... it comes to labeling and storing hundreds of thousands ... has benefitted her research. , “At Brady, we design ...
(Date:10/31/2014)... ATLANTA , Oct. 31, 2014  Atlanta-based ... research efforts accompanying the onset of Ebola by ... options. Scientists at Georgia Tech,s Center for Computational ... and algorithms to find alternative uses for existing ... be able to aid the bout against Ebola. ...
(Date:10/30/2014)... London, UK (PRWEB) October 29, 2014 ... because of the world economic crisis during 2008-2009, especially ... demand has recovered and currently is keeping to a ... PVC output volume is utilized in the construction segment. ... production of pipes, profiles, tubing, sheets and rigid film. ...
Breaking Biology Technology:SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Brady Debuts New Lab Label Testimonial Video 2Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3
... Since Start of Q4 2008 , - Evaluation of strategic ... Board RoleSAN DIEGO, Jan. 5 ADVENTRX Pharmaceuticals, Inc. (NYSE ... further reduction-in-force in an effort to extend its remaining cash ... follows a reduction implemented in October 2008. In all, ...
... Jan. 5 Theodosius Dobzhansky, the late great geneticist ... makes sense except in the light of evolution."This year ... 1809) and the 150th anniversary of the publication of ... the theory of evolution by means of natural selection ...
... Requadt Promoted From PrincipalsCAMBRIDGE, Mass., and SOUTH SAN ... ("Clarus Ventures"), a leading life sciences venture capital ... M.D., Ph.D., M.P.H., to Partner and Scott Requadt, ... 2009.Dr. Cunningham joined Clarus in 2006 and represents ...
Cached Biology Technology:ADVENTRX Announces Further Cost-Cutting Measures 2ADVENTRX Announces Further Cost-Cutting Measures 3ADVENTRX Announces Further Cost-Cutting Measures 4ADVENTRX Announces Further Cost-Cutting Measures 5GEN Joins Charles Darwin 2009 Celebration 2Clarus Ventures Names Two New Partners 2Clarus Ventures Names Two New Partners 3
... Agencourt offers pre-validated ... over 1500 amplicons within ... serine/threonin kinases, and more ... These assays were ...
Glycerol-based mounting medium for immunofluorescence microscopy. Formulated to retard photobleaching of fluorochromes such as fluorescein and rhodamine. Product can also be used as a diluent for fl...
... Mouse anti-Yersinia pestis F1 antigen, ... Applications: ELISA: Use at ... at an assay dependent dilution. WB: ... Predicted molecular weight: 18 kDa. Not ...
Anti-Phospho-JKK/SEK1/MKK4 pAb Description: 100 g rabbit polyclonal antibody. Reacts with human/mouse/rat. Tested in WB. Research Focus: signal transduction Storage: -20C Shipping Tem...
Biology Products: