Navigation Links
Nasal mucosal inhalation of AD vaccine attenuates Aβ1-42-induced cytotoxicity
Date:7/9/2014

Cholinergic inhibitors and N-methyl-D-aspartate receptor antagonists can alleviate the symptoms of Alzheimer's disease, but fail to affect irreversible cognitive dysfunction and effectively scavenge amyloid beta peptide in the brain. Amyloid beta peptide (Aβ) vaccines reduced and eliminated Aβ deposition in an Alzheimer's disease (AD) transgenic mouse model, and significantly improved behavioral and cognitive impairment. Dr. Yunpeng Cao and his team, First Affiliated Hospital of China Medical University, China immunized AD transgenic mouse models with Plp-Adeno-X-CMV-(Aβ3-10)10-CpG via nasal mucosal inhalation. They found that Plp-Adeno-X-CMV-(Aβ3-10)10-CpG vaccine can produce strong T helper 2 humoral immune responses, and avoid Aβ1-42-caused T helper 1 immune responses and Aβ1-42-induced cytotoxicity. Therefore, Plp-Adeno-X-CMV-(Aβ3-10)10-CpG vaccine can be used as a novel type of AD vaccine. These findings were published in Neural Regeneration Research (Vol. 9, No. 8, 2014).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Intranasal neuropeptide Y may offer therapeutic potential for post-traumatic stress disorder
2. AcelRx Pharmaceuticals Receives First U.S. Patent for Small-Volume Oral Transmucosal Dosage Forms
3. First positive results toward a therapeutic vaccine against brain cancer
4. Researchers shut down a SARS cloaking system; findings could lead to SARS, MERS vaccines
5. UNL team explores new approach to HIV vaccine
6. Ebola vaccine success highlights dilemma of testing on captive chimps to save wild apes
7. New experimental vaccine produces immune response against MERS virus
8. New technique brings us closer to HIV and Hepatitis C vaccines
9. Potential lung cancer vaccine shows renewed promise
10. Researchers have identified a novel immunological mechanism of great importance for vaccine developm
11. Can personalized tumor vaccines improve interleukin-2 treated metastatic melanoma?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
(Date:5/23/2017)... May 23, 2017  Hunova, the first robotic gym for the rehabilitation ... officially launched in Genoa, Italy . The first 30 ... and the USA . The technology was developed and ... by the IIT spin-off Movendo Technology thanks to a 10 million euro ... Release, please click: ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017 /PRNewswire/ ... biotech executive search and leadership development, and Virdis Group, global ... created an exclusive alliance that enables clients to leverage the ... "For our clients here in the ... to a diverse population of leadership talent throughout the US, ...
(Date:8/15/2017)... , ... August 15, 2017 , ... ... the largest Asian exhibitions for analytical and scientific instruments. This year’s symposium, organized ... “New Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss ...
(Date:8/15/2017)... ... August 15, 2017 , ... Coffea ... various biotic and abiotic factors. During this educational webinar, participants will learn about ... well as gain a better understanding of how genomics is important for coffee ...
(Date:8/14/2017)... ... 2017 , ... The Conference Forum has confirmed the one-day agenda ... September 6, 2017 at the Marriott Copley Place in Boston, MA. , Returning as ... Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, who leads 19 industry speakers in discussing ...
Breaking Biology Technology: