Navigation Links
Nanotechnology holds promise for STD drug delivery
Date:5/3/2009

New Haven, Conn. Yale researchers describe a breakthrough in safe and effective administration of potential antiviral drugs small interfering RNA (siRNA) molecules that silence genes the first step in development of a new kind of treatment for sexually transmitted diseases (STDs). The work is reported May 4 as an advance online publication of Nature Materials.

"RNA interference is a promising approach for prevention and treatment of human disease," said lead author Kim Woodrow, Yale postdoctoral fellow in Yale's School of Engineering & Applied Science. "We wanted to develop a new strategy of delivering siRNAs with a FDA-approved material."

As their name suggests, siRNAs interfere and knock out the function of genes in higher organism as well as in microbes that may cause STDs. The researchers designed siRNAs to target a gene expressed widely in the lining of the female mouse reproductive tract, in this proof-of-principle work.

Using densely-loaded nanoparticles made of a biodegradable polymer known as PLGA, the researchers created a stable "time release" vehicle for delivery of siRNAs to sensitive mucosal tissue like that of the female reproductive system.

They found that the particles, loaded with the drug agent, moved effectively in two important ways, penetrating to reach cells below the surface of the mucosa and distributing throughout the vaginal, cervical, and uterine regions. Furthermore, the siRNAs stayed in the tissues for at least a week and knockdown of gene activity lasted up to 14 days.

While past work has focused on delivery of siRNAs with liposomes, bubble-like carriers made of phospholipids similar to those found in cell membranes, liposomes are potentially more toxic to the mucosal tissues and are unable to provide sustained release. In the current work, the researchers demonstr
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Yale scientists use nanotechnology to fight E. coli
2. Nanotechnology: Whats that?
3. Rice University nanotechnology expert to give testimony
4. US government delays nanotechnology safety measures
5. Rice University expert calls for coordination in nanotechnology research
6. NIH recognizes Clemson nanotechnology for molecule tracking
7. Nanotechnology and the media: The inside story
8. Using nanotechnology, UCLA researchers discover cancer cells feel much softer than normal cells
9. FDLI, PEN co-sponsor major conference on nanotechnology
10. Iridescence workshop promotes natures nanotechnology
11. Strategy for nanotechnology-related environmental, health and safety research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanotechnology holds promise for STD drug delivery
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/18/2014)... 18, 2014  The Secure Identity & Biometrics ... jointly announce the formation of The Airport Entry ... Identity and Biometric Entry and Exit Solutions ... official support from BORDERPOL, the international non-profit organization ... provide expertise regarding border security, traveler and migration ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... WASHINGTON, D.C. (March 6, 2011) -- New findings from researchers ... Sick Children in Toronto may shed light on the mechanisms ... a critical aspect of cell signaling not well understood at ... of the macrophage protein CD36, a clustering-responsive class B scavenger ...
... MARCH 4, 2011 North and South Carolina have seen ... years. In North Carolina alone, swine production generates approximately a ... so many large-scale pig farms leads to the problem of ... the Carolinas is storing animal waste in anaerobic lagoons. They ...
... of Engineering researcher is seeking a new way to ... their voice. But this isn,t "The King,s Speech," the ... therapy to battle a stammer. Instead, Alexander Leonessa ( ... of stroke patients and others who have suffered paralysis ...
Cached Biology News:Environmental impact of animal waste 2Virginia Tech researcher seeks to use electrical stimulation to give voice to stroke patients 2Virginia Tech researcher seeks to use electrical stimulation to give voice to stroke patients 3
(Date:12/24/2014)... “Preparative & Process Chromatography Market by ... Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, End ... to 2019” provides a detailed overview of the ... and strategies impacting the preparative and process chromatography ... the revenue and share analysis. , Full ...
(Date:12/24/2014)... On Friday, December 19, 2014, President ... and Continuing Resolution Appropriations Act of 2015, which ... eligible to receive funding through the Congressionally Directed ... of Defense (DoD). The Hydrocephalus Association (HA), working ... is celebrating this victory for the over 1 ...
(Date:12/24/2014)... 2014 The report expects global cell ... 2019. It also provides a carefully analyzed data about ... for the market. , Full Copy of Report @ ... global market for cell expansion will keep witnessing growth ... this growth to be driven by rapid technological advancements, ...
(Date:12/24/2014)... PharmaBoardroom,s new report, , ... available for free download , digs deep into this ... in the sector today. One area where ... in developing a homegrown pharmaceutical manufacturing base, even if the ... some way off. A cursory comparison with neighboring ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... California taxpayer and consumer rights group believes the U.S. ... the Wisconsin Alumni Research Foundation regarding its ... foundation said its recent $1 million jury reward in ... patents. , ,Representatives of the Foundation for Taxpayer ...
... Jim Doyle has signed into law Senate Bill 338, ... obstacles that stand in the way of University of ... researchers more quickly turn research ideas into potential business ... review whenever UW faculty and staff try to start ...
... capitalist in San Francisco or Boston, and youre on the verge ... Everything looks right: The management team is in place, the business ... ,But then a lawyer steps into the room, clears her throat ... law. Better not write that check, she says, until you learn ...
Cached Biology Technology:California group says ruling weakens WARF's stem cell patent 2California group says ruling weakens WARF's stem cell patent 3California group says ruling weakens WARF's stem cell patent 4Why repealing the shareholder wage lien law makes sense 2Why repealing the shareholder wage lien law makes sense 3
ANTI-HUMAN CYTOKINES, GROWTH FACTORS (polyclonal rabbit (or goat) antibodies) Human TARC - Biotin...
Rabbit polyclonal to Glutathione S Transferase alpha ( Abpromise for all tested applications). Antigen: Full length protein: Human Glutathione S Transferase alpha. Entrez GeneID: 2938 Swi...
Anti-Mouse IgM Heavy Chain:FITC, Clone LO-MM-9, Monoclonal Antibody...
Rabbit polyclonal to FOXJ2 ( Abpromise for all tested applications). entrezGeneID: 55810 SwissProtID: Q9P0K8...
Biology Products: