Navigation Links
Nanotechnology could help fight diabetes
Date:5/16/2013

strength, allowing insulin to leak out.

The MIT team set out to create a sturdy, biocompatible system that would respond more quickly to changes in glucose levels and would be easy to administer.

Their system consists of an injectable gel-like structure with a texture similar to toothpaste, says Gu, who is now an assistant professor of biomedical engineering and molecular pharmaceutics at the University of North Carolina at Chapel Hill and North Carolina State University. The gel contains a mixture of oppositely charged nanoparticles that attract each other, keeping the gel intact and preventing the particles from drifting away once inside the body.

Using a modified polysaccharide known as dextran, the researchers designed the gel to be sensitive to acidity. Each nanoparticle contains spheres of dextran loaded with an enzyme that converts glucose into gluconic acid. Glucose can diffuse freely through the gel, so when sugar levels are high, the enzyme produces large quantities of gluconic acid, making the local environment slightly more acidic.

That acidic environment causes the dextran spheres to disintegrate, releasing insulin. Insulin then performs its normal function, converting the glucose in the bloodstream into glycogen, which is absorbed into the liver for storage.

Long-term control

In tests with mice that have Type 1 diabetes, the researchers found that a single injection of the gel maintained normal blood-sugar levels for an average of 10 days. Because the particles are mostly composed of polysaccharides, they are biocompatible and eventually degrade in the body.

The researchers are now trying to modify the particles so they can respond to changes in glucose levels faster, at the speed of pancreas islet cells. "Islet cells are very smart. They can release insulin very quickly once they sense high sugar levels," Gu says.

Before testing the particles in humans, the researchers pl
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Discovery of first motor with revolution motion in a virus-killing bacteria advances nanotechnology
2. Innovative uses of nanotechnology in food and agriculture
3. Bioengineer studying how to send drugs to lungs through nanotechnology
4. Nanotechnology drug delivery shows promise for treatment of pediatric cancer
5. Global Market for Nanotechnology to Reach $3.3 Trillion by 2018
6. European boost for DNA nanotechnology
7. Mercury in water, fish detected with nanotechnology
8. Realizing the promise of RNA nanotechnology for new drug development
9. New study shows promise in using RNA nanotechnology to treat cancers and viral infections
10. Understanding the biological and ecological implications of safe nanotechnology
11. Nanotechnology breakthrough could dramatically improve medical tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... November 4, 2014   ... growth   Fuel3D , a developer of ... funding round totaling $6.4 million (£4 million). This funding builds ... earlier this year and paves the way for the commercial ... The funding round was led by Chimera Partners and ...
(Date:11/3/2014)... 3, 2014 Research and Markets has ... - Technologies, Markets and Companies" to their offering. ... and methods, which have already started to play an important ... is replacing the old fashioned bone marrow transplants. Role of ... bound to become a part of medical practice. ...
(Date:11/3/2014)... and preterm birth are linked to increased risk for ... the American College of Rheumatology (ACR) journal, Arthritis ... and pre-term babies were not at greater risk of ... According to the ACR, 27 million Americans over the ... of OA range from mild to severe and include ...
Breaking Biology News(10 mins):Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3Preterm, low birth-weight babies may need new hips in adulthood 2
... D.C. (March 8, 2011) -- Researchers at the University ... Texas at Dallas are reporting today at the 55th ... they are using a novel 3D cell imaging method ... providing a solution to this fundamental problem in cell ...
... 8, 2011 New technology designed to revolutionize ... its initial operating capability, the FBI announced today. ... built by Lockheed Martin, delivers an incremental replacement ... (IAFIS). NGI provides automated fingerprint and latent search ...
... Pa. -- Crabs, fishing, land use and pollution sources ... Bay area, but finding all the available information, especially ... a project of the AmericaView consortium, brings together a ... who needs them for research, planning or other studies. ...
Cached Biology News:FBI Announces Initial Operating Capability for Next Generation Identification System 2ChesapeakeView: Everything you need to know about the bay 2
(Date:11/26/2014)... TOKYO , 25 novembre 2014 Theravalues ... Super sur le marché européen au salon Hi ... Amsterdam ). Curcumine la ... une technologie amorphe (non-cristalline) à des ingrédients approuvés ... est un pigment jaune présent dans la racine ...
(Date:11/26/2014)... -- Theravalues Corporation annuncia con orgoglio il lancio di ... Hi Europe 2014 (dal 2 al 4 dicembre, ... curcumina con la maggiore biodisponibilità di sempre, con una ... dalle norme europee. La curcumina è un ... Curcuma longa ) che è stata associata con attività ...
(Date:11/24/2014)... 24, 2014  IGI Laboratories, Inc. (NYSE MKT: IG), ... generic pharmaceutical company, today announced it has submitted an ... Food and Drug Administration (FDA), which brings the Company,s ... with eighteen submissions now pending at the FDA. ... of the Company, commented, "Our team here at IGI ...
(Date:11/24/2014)... -- Last week, Representatives Gus Bilirakis (R-FL) ... bold bipartisan step on behalf of patients with ... co-sponsors of the legislation include Representatives McCaul (R-TX) ... makers and innovators to "repurpose" major market drugs ... opens the door to the development of hundreds ...
Breaking Biology Technology:La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3IGI Laboratories, Inc. Announces ANDA Submission 2OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2
... be difficult for someone outside of a specialist field ... of available data can be bewildering. New research, published ... Biomedical Semantics , describes a method of social network ... sift through scientific literature and news articles to identify ...
... There was a lot of excitement a few years ... The approach could be used to build nanoparticles of ... as nano-tweezers, remained out of reach. An international team ... Ludwig-Maximillians-Universitaet Muenchen and Professor Friedrich Simmel of the Technische ...
... two-day workshop hosted by the National Nanotechnology Initiative (NNI) ... assess the current landscape of regional, state, and local ... with optional site visits on April 30 ... 319 SW Pine Street, Portland, OR Who: ...
Cached Biology Technology:Social networking shortcut to finding medical experts 2Nano spiral staircases modify light 2Registration now open: 2012 Regional, State, and Local Initiatives in Nanotechnology 2
... These versatile vacuum cups provide flexible ... curved, or irregular surfaces. ,PFG: Flat ... Bellows cup ,PCG: Multiple Bellows cup ... from 25 to 200 mm , ...
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
...
Biology Products: