"Right now, these markers are just passive implants that are inserted into the tumor," says Srinivas Sridhar, a physics professor at Northeastern University and director of the university's Electronic Materials Research Institute. "We're making them active and smart using nanotechnology," he said.
The challenge is designing a system that will work over an extended period of time and target the entire tumor without affecting healthy tissue. The team has already developed a nanoscale polymer coating containing anti-cancer drugs for gold fiducials, which are commonly used markers.
Now, the researchers report they can precisely tailor drug dosage and rate of release in laboratory tests lasting up to three months. The nanoporous morphology of the polymer coatings enabled the controlled release of molecules and nanoparticles. The results also help refine the team's models of drug release kinetics.
The group includes collaborators Mike Makrigiorgos and Robert Cormack from Brigham & Women's Hospital and Dana-Farber Cancer Institute.
The Presentation " Release Kinetics of Radio-Sensitizers From Nanoporous Coatings On Gold Fiducials : Biological In-Situ Dose-Painting for IGRT" by C Stambaugh et al. will be at 4:12 p.m. on Wednesday, July 21 in room 204B of the Pennsylvania Convention Center.
2) TUMOR TRACKING WITH SMART PROBING A STOCK MARKET APPROACH
Pinpointing tumor location and behavior can be as risky and frustrating as estimating the rise and fall of stocks in the market. A new model, developed by Dan Ruan, Ph.D., an instructor in radiation oncology at Stanford University, and colleagues, employs tactics similar to those used by market analysts. Ruan will p
|Contact: Jason Socrates Bardi|
American Institute of Physics