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re therapies that up the dose given to radiation-resistant cells and drop the dose given to radiation-sensitive cells.

"There are some regions that are overtreated in a tumor and some that are undertreated," says Jeraj. "The idea is of dose painting is to treat each region properly."

One potential target for increasing the dose, said Jeraj, is the 20 percent of cells of the tumor that show high hypoxia, a low metabolic rate, and low proliferation. Candidates for a lower dose include the 30 percent of cells that show high proliferation, but low hypoxia and intermediate metabolism.

Jeraj says that future studies will be needed to identify which of these regions are more or less resistant to single a treatment, and new tools must be developed to measure how one region changes size in relationship to the tumor as a whole.

The presentation "Classification and Characterization of Tumor Subpopulations Using Molecular Imaging" by R Jeraj et al. will be at 1:30 p.m. on Monday, July 19 in room 204B of the Philadelphia Convention Center.



In recent years, nanoparticles have shown promise for detecting and imaging tumors. At the Stanford University School of Medicine in California, an interdisciplinary group of researchers has developed a range of nanocrystals that work with X-rays to light up cancer cells with a red glow.

Their technique, called X-ray luminescence computed tomography, could see smaller cancerous lesions with less radiation dosage than current technologies used to image biological processes in the body -- such as PET/CT scans.

The nanocrystals created by Guillem Pratx and his colleagues produce infrared light when exposed to X-rays. The researchers hope to coat the crystals with polymers and proteins

Contact: Jason Socrates Bardi
American Institute of Physics

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