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Date:7/14/2010

eater advantages, including even finer spatial resolution and a threefold improvement in dose-efficiency at the highest spatial frequencies. Work is continuing in Dr. Stephen Rudin's imaging lab to further advance the development of this promising new technology and to bring it to the clinic, where it is expected to provide substantial improvements in patient treatment outcomes.

The presentation " The Next Generation Solid State X-Ray Image Intensifier (SSXII)" by A Kuhls-Gilcrist et al. will be at 4:50 p.m. on Wednesday, July 21 in room 201C of the Philadelphia Convention Center.

ABSTRACT: http://www.aapm.org/meetings/amos2/pdf/49-12777-99871-601.pdf


12) TO TREAT CANCER, SUBDIVIDE AND CONQUER

Today's cancer therapies deliver a uniform amount of radiation to the tumor as a whole. But cancer masses are not uniform throughout, and new research suggests that these treatments could be made more effective by targeting different regions of the tumor with different doses.

A comprehensive molecular imaging study lead by Robert Jeraj's group at the University of Wisconsin, Madison, showed that many tumors contain three distinct subpopulations of cells.

Thirteen patients with head and neck cancer underwent PET/CT scans that measured three different characteristics: metabolism, cell proliferation, and oxygen deprivation (hypoxia). Previous studies have shown that these three factors can vary within a tumor, and each is known to effect how a tumor reacts to treatment.

Using a computer algorithm to classify the regions based on these three parameters it was discovered that most of the tumors contained three statistically- different subpopulations with distinct profiles. He suspects that this classification into distinct tumor subregions may be generalizable to many different kinds of cancer.

Jeraj hopes to develop futu
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Contact: Jason Socrates Bardi
jbardi@aip.org
858-775-4080
American Institute of Physics
Source:Eurekalert

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