Navigation Links
'Nanosponge vaccine' fights MRSA toxins

fore, use a heat or chemically processed version of the toxin that unravels some of its proteins and makes it a little weaker. But this process also makes the immune response to the toxin a little weaker.

"The more you heat it, the safer the toxin is, but the more you heat it, the more you damage the structure of the protein," Zhang explained. "And this structure is what the immune cell recognizes, and builds its antibodies against."

The nanosponge toxoid vaccine gets around this problem by detainingbut not changingthe staph toxin. Like a dangerous but handcuffed prisoner, the staph toxin can be led to the dendritic cells of the immune system without causing any harm.

Before this, "there was no way you could deliver a native toxin to the immune cells without damaging the cells," Zhang said. "But this technology allows us to do this."

Each vaccine particle is approximately 85 nanometers in diameter; for comparison, about 1000 of them would fit across the width of a single human hair. They are cleared from the body after injection in about two weeks, the researchers found.

Staphylococcus aureus

Staph bacteria are one of the most common causes of skin infections, and can cause blood poisoning and surgical infections as well as pneumonia. According to the Centers for Disease Control and Prevention, about 80,000 Americans suffer from invasive MRSA infections each year, and over 11,000 of those individuals die. At the moment, there are no vaccines approved to protect humans against the toxins associated with staph infections, including those caused by MRSA strains.

The idea for a staph vaccine came about when the researchers considered the success of their nanosponge. If the particle was so good at collecting toxins, they wondered, what were the potential uses of a particle full of toxin? "To be honest, we never thought about the vaccine use from the beginning," Zhang noted. "But when we do research, we

Contact: Daniel Kane
University of California - San Diego

Page: 1 2 3 4

Related biology news :

1. Nanosponges soak up oil again and again
2. New malaria vaccines roadmap targets next generation products by 2030
3. A new DNA vaccine induces a Th2 immune response in Alzheimers disease mice
4. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
5. Reassuring findings released in national study of influenza vaccine safety in pregnancy
6. New investment fund will advance late-stage vaccines, other global health technologies
7. Scientists closer to universal flu vaccine after pandemic natural experiment
8. University of Maryland researchers studying vaccine to prevent potential bird flu pandemic
9. Scientists engineer strain of MERS coronavirus for use in a vaccine
10. IDRI and Zydus sign agreement for development of IDRIs vaccine candidate for visceral leishmaniasis
11. New materials, progress toward an HIV vaccine, and more at meeting of crystallographers
Post Your Comments:
Related Image:
'Nanosponge vaccine' fights MRSA toxins
(Date:7/29/2014)... types of cell, including sperm, bacteria and algae, ... These protrusions, about one-hundredth of a millimetre long, ... fluid. Similar, shorter structures called cilia are found ... perform roles such as moving liquids over the ... versatile: they transport mucus and expel pathogens from ...
(Date:7/29/2014)... new study from UC San Francisco is the first ... accumulate overtime and accelerate cellular aging, these negative effects ... and sleeping well. , "The study participants who ... shortening than the ones who didn,t maintain healthy lifestyles, ... lead author Eli Puterman, PhD, assistant professor in the ...
(Date:7/28/2014)... About 100 drugs already approved by the U.S. Food ... prevent the growth of certain bacterial pathogens inside human ... Mediterranean spotted fever. The findings, published in mBio ... for Microbiology, demonstrate a new way of identifying non-antibiotic ... , A handful of drugs on the list ...
Breaking Biology News(10 mins):Microscopic rowing -- without a cox 2Microscopic rowing -- without a cox 3Healthy lifestyle may buffer against stress-related cell aging, study says 2New route to identify drugs that can fight bacterial infections 2
... operations are an important emission source of air ... Recent inventories suggest that animal manure makes a ... consequence, greenhouse gas emissions can potentially become a ... animal production and technologies are needed to mitigate ...
... is available in French . , A ... promise of new treatments for obesity in humans, McGill University ... journal Nature , and was funded by the Canadian ... In lean times, a normal Caenorhabditis elegans worm goes into ...
... developed world is forecast to lead to a dramatically older ... more people to enjoy healthy and active older age it ... how our bodies change as we age. To help scientists ... UK and US have joined forces to fund a programme ...
Cached Biology News:Oil spray reduces greenhouse gas emissions from pig finishing barns 2Key to 'curing' obesity may lie in worms that destroy their own fat: McGill researchers 2
(Date:7/29/2014)... 29, 2014 TransVac Solutions, the trusted ... and transport solutions for hospitals, will be exhibiting at ... (ASHE) Annual Conference & Technical Exhibition Aug. 3-6 in ... technology for making hospitals cleaner, reducing infection risk and ... hospital’s life cycle. Staff will be available at ...
(Date:7/29/2014)... & Rockville, MD (PRWEB) July 29, 2014 ... Inc. (ITI), a vaccine pioneer in the biotechnology ... services firm Newport Coast Securities, Inc. to explore ... is commercializing LAMP-vax technology, a breakthrough vaccine platform ... and immunotherapy market. The company exclusively licensed the ...
(Date:7/29/2014)... 2014 Philadelphia’s newest entrepreneurial incubation space is ... start. The Innovation Center @3401 , a collaborative effort ... Science Center to help attract and nurture start-up businesses ... 28. , The Innovation Center @3401 (ic@3401), ... Streets, is the new home of DreamIt Ventures ...
(Date:7/29/2014)... Tenn. (PRWEB) July 29, 2014 ... in biomass feedstock supply innovation and supply chain ... proprietary feedstock management systems, Energy Grange™ and Supply ... of R&D and in-the-field testing aimed at consolidating ... offering benefits to landowners, farmers and feedstock end ...
Breaking Biology Technology:TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3Innovation Center @3401 Opens for Business; DreamIt Ventures and First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and First Residents 3Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4
... come up with an explanation as to where and how ... turn out to be the first step on the way ... increasing oil production from Danish oil fields. , A research ... Chemistry at University of Copenhagen has investigated drill cores collected ...
... May 11 Sanofi-aventis U.S. announced today that it ... commercial rights to Oforta(TM) (fludarabine phosphate film-coated tablets), an ... Oforta is currently approved in the United States for ... B-cell CLL. "We are extremely pleased to add ...
... VRUS ), a clinical stage pharmaceutical company ... treat viral infections, reported financial results and operational highlights ... Financial Results Revenues were $1.9 million during the quarter ... the quarter ended March 31, 2008 and reflect the ...
Cached Biology Technology:New Danish research shows how oil gets stuck underground 2Sanofi-aventis U.S. to Acquire Oral Chronic Lymphocytic Leukemia Treatment 2Sanofi-aventis U.S. to Acquire Oral Chronic Lymphocytic Leukemia Treatment 3Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 2Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 3Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 4Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 5Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 6Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 7Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 8
... C-1-tetrahydrofolate synthase, ... [Includes: Methylenetetrahydrofolate dehydrogenase ... cyclohydrolase (EC; ...]. [Source:Uniprot/SWISSPROT;Acc:P11586] ...
Request Info...
Lipid-rich bovine serum albumin for cell culture (1). It is chromatographically purified and has an IgG content 0.1% (w/w)....
Chicken anti-EEA1...
Biology Products: