Navigation Links
Nanosensors made from DNA may light path to new cancer tests and drugs
Date:9/7/2011

(Santa Barbara, Calif.) Sensors made from custom DNA molecules could be used to personalize cancer treatments and monitor the quality of stem cells, according to an international team of researchers led by scientists at UC Santa Barbara and the University of Rome Tor Vergata.

The new nanosensors can quickly detect a broad class of proteins called transcription factors, which serve as the master control switches of life. The research is described in an article published in Journal of the American Chemical society.

"The fate of our cells is controlled by thousands of different proteins, called transcription factors," said Alexis Valle-Blisle, a postdoctoral researcher in UCSB's Department of Chemistry and Biochemistry, who led the study. "The role of these proteins is to read the genome and translate it into instructions for the synthesis of the various molecules that compose and control the cell. Transcription factors act a little bit like the 'settings' of our cells, just like the settings on our phones or computers. What our sensors do is read those settings."

When scientists take stem cells and turn them into specialized cells, they do so by changing the levels of a few transcription factors, he explained. This process is called cell reprogramming. "Our sensors monitor transcription factor activities, and could be used to make sure that stem cells have been properly reprogrammed," said Valle-Blisle. "They could also be used to determine which transcription factors are activated or repressed in a patient's cancer cells, thus enabling physicians to use the right combination of drugs for each patient."

Andrew Bonham, a postdoctoral scholar at UCSB and co-first author of the study, explained that many labs have invented ways to read transcription factors; however, this team's approach is very quick and convenient. "In most labs, researchers spend hours extracting the proteins from cells before analyzing them," said Bo
'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists use nanosensors for first time to measure cancer biomarkers in blood
2. A London effort to develop point-of-care nanosensors for HIV diagnosis and monitoring
3. First global portrait of greenhouse gases emerges from pole-to-pole flights
4. TF beacons may light path to new cancer tests and drugs
5. Highlights of upcoming conference on aldosterone & the ENaC/Degenerin family of ion channels
6. Up from the depths: How bacteria capture carbon in the twilight zone
7. Weight loss without the hunger: Cornell scientists say eat a lighter lunch
8. The genome of mesopolyploid crop Brassica rapa sheds new light on the study of genome evolution
9. New imaging method sheds light on cell growth
10. New theory may shed light on dynamics of large-polymer liquids
11. Small molecules shed light on cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanosensors made from DNA may light path to new cancer tests and drugs 
(Date:8/27/2014)... willing to pay a premium for fruits, vegetables and ... the label claims is another matter. Now scientists studying ... to make sure farms are labelling their produce appropriately. ... Agricultural and Food Chemistry , could help prevent organic ... Food Safety Authority and the Wuerzburg University note that ...
(Date:8/27/2014)... studies have shown that excessive iron is ... disease. Previous studies from Chunyan Guo and ... have shown that baicalin prevented iron accumulation ... transporter 1 expression, and increased ferroportin 1 ... Parkinson,s disease rats. However, the relationship between ...
(Date:8/27/2014)... of Warwick research finds , Gamblers show the ... new research has shown. , Researchers, led by Dr ... Psychology, conducted tests that found that both human gamblers ... high-value than low-value rewards. , Published in Biology ... show the important role that memories of previous biggest ...
Breaking Biology News(10 mins):Gamblers are greedy bird-brains, University of Warwick research finds 2
... Unlike most of our sensory systems that detect only one ... detecting both chemical and mechanical stimuli to improve how we ... in the March issue of Nature Neuroscience. , This ... reaction in olfactory nerve cells, which control how our brain ...
... the University of Liverpool have found how two molecules fight ... , Researchers discovered that a large protein, which forms a ... secondary tumours, is attacked by a small protein that exists ... breast, lung and colorectal cancer, infected cells lose growth control ...
... onset of type 1 diabetes in mice prone to ... on the surface of immune T-cells. According to the ... January issue of the journal Diabetes, have significant implications ... More than 700,000 Americans have type 1 diabetes, an ...
Cached Biology News:Penn study on olfactory nerve cells shows why we smell better when we sniff 2Scientists discover how body fights to control spread of cancer 2Antibody therapy prevents type 1 diabetes in mice 2
(Date:8/28/2014)... August 28, 2014 PrimeSource Building ... materials, selected SoundConnect to support their ... based audio and web conferencing platform GlobalMeet powered ... PrimeSource’s employees’ needs. SoundConnect delivers award winning ... PrimeSource Building Products will be utilizing GlobalMeet ...
(Date:8/27/2014)... -- Rhythm, a biopharmaceutical company developing peptide therapeutics that ... metabolic disorders, announced today that it has filed a ... and Exchange Commission (SEC) relating to the proposed initial ... number of shares to be offered and the price ... Citigroup and Cowen and Company will act ...
(Date:8/27/2014)... August 27, 2014 The Global and ... study on the current state of the Trifluoroacetic Acid ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:8/27/2014)... August 27, 2014 “We are honored ... vendors,” said Ven Thangaraj, CEO of Radiant Sage. “We ... are taking the imaging corelab market to a different ... and research organizations to efficiently and effectively manage the ... data to be analyzed and read by trained physicians. ...
Breaking Biology Technology:PrimeSource Chooses SoundConnect as Collaboration Provider 2Rhythm Files Registration Statement for Proposed Initial Public Offering 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2
... CRY ), a,biomaterials, medical device and tissue processing ... the FBR Capital Markets Annual,Spring Investor Conference, Thursday, May ... City., Steven G. Anderson, president and chief executive ... Time., CryoLife,s live presentation may be accessed through ...
... May 28 /Xinhua-PRNewswire-FirstCall/ -- AMAG,Pharmaceuticals, Inc. (Nasdaq: ... SSRX ), a,leading Chinese biotechnology company, ... commercialization agreement for ferumoxytol, an intravenous,iron replacement ... deficiency,anemia in chronic kidney disease (CKD) patients., ...
... May 27 CellCyte Genetics,Corporation (CellCyte) (OTC ... provide shareholders, potential investors and journalists,with accurate ... Room powered Web site: http://www.cellcyte.com ... or sources for stories from,CellCyte can access ...
Cached Biology Technology:CryoLife to Present at FBR Capital Markets Annual Spring Investor Conference 2AMAG Pharmaceuticals, Inc. and 3SBio, Inc. Announce Strategic Partnership to Develop and Commercialize Ferumoxytol in China 2AMAG Pharmaceuticals, Inc. and 3SBio, Inc. Announce Strategic Partnership to Develop and Commercialize Ferumoxytol in China 3
... Best: DASGIPs Process Control integrates Process ... comprehensive documentation for cultivation processes. A ... pH, dissolved oxygen, temperature and agitation ... Profiles, e.g. constant or scheduled media ...
... LC Sciences provides a genome-wide microRNA ... and proprietary probe design, which enable highly ... (1-3). We have standard arrays for mature ... latest version of the Sanger miRBase database ...
... synthetic peptide whose sequences are derived from mouse resistin protein. ... - S - M - P - L - C - ... - D - K - K - I - K - ... used for neutralization and control experiments with the polyclonal antibody that ...
... Imaging System, Basic Package Superior Protein ... Range: The ProXPRESS 2D Proteomic Imaging System ... for both proteomic and general life science ... enabling the use of all dyes in ...
Biology Products: