Navigation Links
Nanorobot for transporting drugs in the body
Date:12/2/2013

A nanorobot is a popular term for molecules with a unique property that enables them to be programmed to carry out a specific task. In collaboration with colleagues in Italy and the USA, researchers at Aarhus University have now taken a major step towards building the first nanorobot of DNA molecules that can encapsulate and release active biomolecules.

In time, the nanorobot (also called a DNA nanocage) will no doubt be used to transport medications around in the body and thereby have a targeted effect on diseased cells.

Design using the body's natural molecules

Using DNA self-assembly, the researchers designed eight unique DNA molecules from the body's own natural molecules. When these molecules are mixed together, they spontaneously aggregate in a usable form the nanocage (see figure).

The nanocage has four functional elements that transform themselves in response to changes in the surrounding temperature. These transformations either close (figure 1A) or open (figure 1B) the nanocage. By exploiting the temperature changes in the surroundings, the researchers trapped an active enzyme called horseradish peroxidase (HRP) in the nanocage (figure 1C). They used HRP as a model because its activity is easy to trace.

This is possible because the nanocage's outer lattice has apertures with a smaller diameter than the central spherical cavity. This structure makes it possible to encapsulate enzymes or other molecules that are larger than the apertures in the lattice, but smaller than the central cavity.

The researchers have just published these results in the renowned journal ACS Nano. Here the researchers show how they can utilise temperature changes to open the nanocage and allow HRP to be encapsulated before it closes again.

They also show that HRP retains its enzyme activity inside the nanocage and converts substrate molecules that are small enough to penetrate the nanocage to products inside.

The encapsulation of HRP in the nanocage is reversible, in such a way that the nanocage is capable of releasing the HRP once more in reaction to temperature changes. The researchers also show that the DNA nanocage with its enzyme load can be taken up by cells in culture.

Looking towards the future, the concept behind this nanocage is expected to be used for drug delivery, i.e. as a means of transport for medicine that can target diseased cells in the body in order to achieve a more rapid and more beneficial effect.


'/>"/>

Contact: Birgitta R. Knudsen
brk@mb.au.dk
45-60-20-26-73
Aarhus University
Source:Eurekalert  

Related biology news :

1. FASEB lauds Air India for transporting research animals
2. Newly released FDA draft guidelines for biosimilar drugs to be discussed at conference
3. Nanopills release drugs directly from the inside of cells
4. Genetic variation in East Asians found to explain resistance to cancer drugs
5. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
6. Internet and new drugs: A challenge for public health
7. Study raises questions about use of anti-epilepsy drugs in newborns
8. Drugs from lizard saliva reduces the cravings for food
9. A new method detects traces of veterinary drugs in baby food
10. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
11. MIT-designed cooler preserves tuberculosis drugs, records doses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanorobot for transporting drugs in the body
(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... PARK, CA (PRWEB) , ... May 23, 2017 , ... ... the publication of “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic ... is the result of a collaboration with Dr. Dino Di Carlo and Dr. Matthew ...
(Date:5/23/2017)... ... May 23, 2017 , ... Kathy Goin ... of Clinical Operations. She brings years of expertise in establishing and leading clinical ... foundation as a licensed occupational therapist, through a variety of leadership roles in ...
(Date:5/23/2017)... ... May 23, 2017 , ... Cambridge Semantics , the leading ... year’s Bio-IT World Conference and Expo in Boston May 23-25 with a ... The Anzo Smart Data Lake is also a finalist for the Best of ...
(Date:5/22/2017)... ... ... Stratevi, a boutique firm that partners with healthcare companies to creatively develop ... in downtown Boston at 745 Atlantic Ave. , “We are seeing that even ... the value they provide, not just to patients, but also payers. Having a presence ...
Breaking Biology Technology: