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Nanoresearchers challenge dogma in protein transportation in cells
Date:9/21/2009

n small vesicles a kind of soap bubbles that like cells are surrounded by membranes. The researchers made vesicles of different sizes in the laboratory and tested how different types of proteins bound to the vesicle membrane. They observed that the smaller the size of the vesicle, and more curved the membrane, the higher the number of cracks available and therefore the greater the number of proteins that can be bound pr. surface area.

- The moment we understood that the most critical parameter in our observations was membrane-shape we immediately thought that maybe we found a general mechanism that would apply to many other types of proteins apart from the ones we were studying. So we tested G proteins that are important signalling proteins attached to the membrane in a different way, using a lipid anchor. Our data confirmed that the model was indeed general, explains Vikram Bhatia, Nano-Science Center and Department of Nanoscience and Pharmacology.

- Unravelling the overarching importance of membrane-shape for the localization of literally hundreds of important signalling proteins will prove critical to our understanding of a plethora of biological process many of which are directly linked to important diseases, emphasises Associate Professor Dimitrios Stamou.


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Contact: Dimitrios Stamou
stamou@nano.ku.dk
454-116-0468
University of Copenhagen
Source:Eurekalert

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