Navigation Links
Nanopore opens new cellular doorway for drug transport
Date:10/23/2013

A living cell is built with barriers to keep things out and researchers are constantly trying to find ways to smuggle molecules in.‬ ‪Professor Giovanni Maglia (Biochemistry, Molecular and Structural Biology, KU Leuven) and his team have engineered a biological nanopore that acts as a selective revolving door through a cell's lipid membrane. The nanopore could potentially be used in gene therapy and targeted drug delivery.‬‬‬‬‬‬‬

All living cells are enclosed by a lipid membrane that separates the interior of the cell from the outside environment. The influx of molecules through the cell membrane is tightly regulated by membrane proteins that act as specific doorways for the trafficking of ions and nutrients. Membrane proteins can also be used by cells as weapons. Such proteins attack a cell by making holes nanopores in 'enemy' cell membranes. Ions and molecules leak from the holes, eventually causing cell death.‬‬

‪Researchers are now trying to use nanopores to smuggle DNA or proteins across membranes. Once inside a cell, the DNA molecule could re-programme the cell for a particular action. Professor Maglia explains: "‪We are now able to engineer biological nanopores, but the difficult part is to precisely control the passage of molecules through the nanopores' doorways. We do not want the nanopore to let everything in. Rather, we want to limit entry to specific genetic information in specific cells." ‬‬‬‬‬‬‬‬‬‬‬‬‬‬

‪Professor Maglia and his team succeeded in engineering a nanopore that works like a revolving door for DNA molecules. "We have introduced a selective DNA revolving door atop of the nanopore. Specific DNA keys in solution hybridise to the DNA door and are transported across the nanopore. A second DNA key on the other side of the nanopore then releases the desired genetic information. A new cycle can then begin with another piece of DNA as long as it has the correct key. In this way, the nanopore acts simultaneously as a filter and a conveyor belt." ‬‬‬‬‬‬‬

"In other words, we have engineered a selective transport system that can be used in the future to deliver medication into the cell. This could be of particular use in gene therapy, which involves introducing genetic material into degenerated cells in order to disable or re-programme them. It could also be used in targeted drug delivery, which involves administering medication directly into the cell. The possibilities are promising."‬‬


'/>"/>

Contact: Giovanni Maglia
giovanni.maglia@chem.kuleuven.be
32-163-27696
KU Leuven
Source:Eurekalert  

Related biology news :

1. DNA prefers to dive head first into nanopores
2. Temp-controlled nanopores may allow detailed blood analysis
3. New NIH awards focus on nanopore technology for DNA sequencing
4. 3-D RNA modeling opens scientific doors
5. Press accreditation opens for World Series of Science
6. Understanding why some people have propensity to disease
7. Major osteoporosis meeting opens in São Paulo
8. Next-generation sequencing technology opens doors to discoveries
9. Media registration opens for Neuroscience 2012, worlds largest brain science meeting
10. Cell research opens new avenues in combating neurodegenerative diseases
11. OpenStax Colleges free textbooks will save students $1 million this fall
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanopore opens new cellular doorway for drug transport
(Date:12/7/2016)... Israel , December 7, 2016 BioCatch ... the expansion of its patent portfolio, which grew to over 40 granted ... , , ... its recently filed patent entitled " System, Device, and Method ... technology that enables device makers to forego costly hardware components needed to ...
(Date:12/6/2016)... 2016 Valencell , the leading innovator ... seen a third consecutive year of triple digit growth ... 2016 with a 360 percent increase in companies who ... was driven by sales of its wrist and ear ... its technology for hearables for fitness and healthcare applications. ...
(Date:12/2/2016)... 1, 2016   SoftServe , a global ... , an electrocardiogram (ECG) biosensor analysis system for ... IoT asset. The smart system ensures device-to-device communication ... wheel and mobile devices to easily ,recognize, and ... As vehicle technology advances, so too must the ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... The report "Acrylic Processing Aid Market by Polymer Type (PVC), Fabrication Process (Extrusion, Injection Molding), ... 2026", published by MarketsandMarkets, the global market size was USD 645.4 Million in ... of CAGR of 6.2% between 2016 and 2026. ... ... , , ...
(Date:12/7/2016)... , Dec. 7, 2016  Muse bio, a privately-held ... today announced that Dr. Kevin Ness has ... Board of Directors. Kevin succeeds Muse ... the company,s Chief Science Officer as well as remains ... of the BioDesign Center at the RAS Energy Institute ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... ... wastewater treatment and resource recovery solutions for industrial facilities, today announced that one ... be the first to use Cambrian’s novel water-energy purchase agreement (WEPA). Under the ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... early access program for SmartBiome -- a novel metagenomic deep-sequencing research platform. ... enrichment and detection of hundreds of different genes. The selective early access ...
Breaking Biology Technology: