Navigation Links
Nanopore opens new cellular doorway for drug transport
Date:10/23/2013

A living cell is built with barriers to keep things out and researchers are constantly trying to find ways to smuggle molecules in.‬ ‪Professor Giovanni Maglia (Biochemistry, Molecular and Structural Biology, KU Leuven) and his team have engineered a biological nanopore that acts as a selective revolving door through a cell's lipid membrane. The nanopore could potentially be used in gene therapy and targeted drug delivery.‬‬‬‬‬‬‬

All living cells are enclosed by a lipid membrane that separates the interior of the cell from the outside environment. The influx of molecules through the cell membrane is tightly regulated by membrane proteins that act as specific doorways for the trafficking of ions and nutrients. Membrane proteins can also be used by cells as weapons. Such proteins attack a cell by making holes nanopores in 'enemy' cell membranes. Ions and molecules leak from the holes, eventually causing cell death.‬‬

‪Researchers are now trying to use nanopores to smuggle DNA or proteins across membranes. Once inside a cell, the DNA molecule could re-programme the cell for a particular action. Professor Maglia explains: "‪We are now able to engineer biological nanopores, but the difficult part is to precisely control the passage of molecules through the nanopores' doorways. We do not want the nanopore to let everything in. Rather, we want to limit entry to specific genetic information in specific cells." ‬‬‬‬‬‬‬‬‬‬‬‬‬‬

‪Professor Maglia and his team succeeded in engineering a nanopore that works like a revolving door for DNA molecules. "We have introduced a selective DNA revolving door atop of the nanopore. Specific DNA keys in solution hybridise to the DNA door and are transported across the nanopore. A second DNA key on the other side of the nanopore then releases th
'/>"/>

Contact: Giovanni Maglia
giovanni.maglia@chem.kuleuven.be
32-163-27696
KU Leuven
Source:Eurekalert  

Page: 1 2

Related biology news :

1. DNA prefers to dive head first into nanopores
2. Temp-controlled nanopores may allow detailed blood analysis
3. New NIH awards focus on nanopore technology for DNA sequencing
4. 3-D RNA modeling opens scientific doors
5. Press accreditation opens for World Series of Science
6. Understanding why some people have propensity to disease
7. Major osteoporosis meeting opens in São Paulo
8. Next-generation sequencing technology opens doors to discoveries
9. Media registration opens for Neuroscience 2012, worlds largest brain science meeting
10. Cell research opens new avenues in combating neurodegenerative diseases
11. OpenStax Colleges free textbooks will save students $1 million this fall
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanopore opens new cellular doorway for drug transport
(Date:8/22/2014)... to important discoveries in basic and clinical research ... mobilized into a complex offensive spanning multiple fronts. ... chemistry lab could help find new and more ... compound that targets a specific enzyme overexpressed in ... cells from brain tumours. , Chemistry professor Christopher ...
(Date:8/22/2014)... American consumers will finally be able to purchase fuel ... as zero-emissions vehicles, most of the cars will run ... that contributes to global warming. , Now scientists at ... uses an ordinary AAA battery to produce hydrogen by ... through two electrodes that split liquid water into hydrogen ...
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. ... growing mobile commerce market, announced today that its shares ... stock to be issued in its proposed underwritten public ... for listing on The Nasdaq Capital Market, subject to ... common stock and warrants, and will trade under the ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... a paradox that,s puzzled scientists for a half-century. ... depends on those species responding differently to the availability ... species draw a blank? Competitors like black gums ... shaded understories of eastern U.S. forests, yet species-level data ...
... for the study of stem cells and to increase capacity ... initiatives announced today by NIH Director Francis S. Collins, M.D., ... Common Fund, which encourages collaborative research programs across the NIH ... single IC could do alone. The programs are all scheduled ...
... , ... ... ... , ...
Cached Biology News:Forest tree species diversity depends on individual variation 2Forest tree species diversity depends on individual variation 3Emerging science, tech advances highlight new NIH Common Fund programs 2Emerging science, tech advances highlight new NIH Common Fund programs 3Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 2Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 3Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 4Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 5Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 6
(Date:8/22/2014)... 2014 Today the Academy of Model Aeronautics ... Court of Appeals for the D.C. Circuit challenging the FAA’s ... the Federal Register on June 25, 2014. , The ... the text and intent of the FAA Modernization and Reform ... prohibition on any new rules or regulations regarding model aircraft ...
(Date:8/22/2014)... for application as catalysts, sensors, drug delivery ... photonics and molecular electronics. Gaining knowledge of ... and chemical properties, has been challenging. Now, ... that high-resolution electron microscopy can be used ... all gold atoms are observed. The results ...
(Date:8/22/2014)... IN (PRWEB) August 22, 2014 The ... community and its members in Alaska that Alaska Governor ... Concurrent Resolution 15, further defining public use of Unmanned ... Systems Task Force. House Bill 255states that it is, ... to images captured by an unmanned aircraft system.” It ...
(Date:8/21/2014)... MD (PRWEB) August 21, 2014 DNA ... making progress in its development of JRC-LAMP-vax, an innovative ... cedar pollen. Phase IC studies began this month in ... to hay fever. , The Japanese red cedar releases ... people in Japan. Mountain Cedar pollen wreaks similar havoc ...
Breaking Biology Technology:AMA Files Petition for Review of FAA’s Interpretive Rule 2A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4
... (Amex:,SGN) has announced that the legendary Earvin "Magic" ... ambulatory heart testing with AFL,s,flagship choice, Signalife,s Fidelity ... the greatest basketball superstars of all time, Mr.,Johnson ... multiple,championships from college to the Los Angeles Lakers ...
... September 13, 2007 at the 14th, International Symposium on Hepatitis C ... ... Glasgow, Scotland, VALLEY COTTAGE, New York, September 6 XTL,Biopharmaceuticals ... a late breaker abstract, entitled "Potent Small Molecule HCV,Inhibitors Affecting NS5A-dependent ...
... They,ve gotten the science wrong. They,ve gotten the law wrong. Why ... we trust them ... Coalition for,Lifesaving Cures responded today as opponents of stem cell cures ... weeks. Said Donn Rubin, Chair of Missouri Coalition for Lifesaving ...
Cached Biology Technology:Legendary Earvin 'Magic' Johnson Joins AFL/Signalife Cardiovascular Protection Team 2Legendary Earvin 'Magic' Johnson Joins AFL/Signalife Cardiovascular Protection Team 3XTL Biopharmaceuticals Announces Presentation of Novel Pre-Clinical Inhibitors of Hepatitis C at an Upcoming International Scientific Conference 23 strikes, you're out? Refiling of Amendment to Change Constitution to Criminalize Stem Cell Cures Shows Trouble with Anti-Cures Cause 2
Phospho- (Ser) 14-3-3 Binding Motif (4E2) Mouse mAb...
Request Info...
Rabbit polyclonal to UBC12 (rating: ****) ( Abpromise for all tested applications). Antigen: Synthetic peptide: RGGYIGSTYFER, corresponding to amino acids 169-180 of UBC12 Entrez Gene ID: 90...
Applications: Beadlyte® assay Stability: 2 years at 4°C (lyophilized) or 6 months at -20°C (rehydrated) ...
Biology Products: