Navigation Links
Nanopolymer shows promise for helping reduce cancer side effects
Date:4/5/2011

WEST LAFAYETTE, Ind. - A Purdue University biochemist has demonstrated a process using nanotechnology to better assess whether cancer drugs hit their targets, which may help reduce drug side effects.

W. Andy Tao, an associate professor of biochemistry analytical chemistry, developed a nanopolymer that can be coated with drugs, enter cells and then removed to determine which proteins in the cells the drug has entered. Since they're water-soluble, Tao believes the nanopolymers also may be a better delivery system for drugs that do not dissolve in water effectively.

"Many cancer drugs are not very specific. They target many different proteins," said Tao, whose findings were published in the early online in the journal Angewandte Chemie International Edition. "That can have a consequence - what we call side effects."

In addition to the drug, the synthetic nanopolymer is equipped with a chemical group that is reactive to small beads. The beads retrieve the nanopolymer and any attached proteins after the drug has done its work. Tao uses mass spectrometry to determine which proteins are present and have been targeted by the drug.

Knowing which proteins are targeted would allow drug developers to test whether new drugs target only desired proteins or others as well. Eliminating unintended protein targets could reduce the often-serious side effects associated with cancer drugs.

Tao said there currently is no reliable way to test drugs for off-targeting. He said drugs are often designed to inhibit or activate the function of a biomolecule associated with cancer, but those drugs tend to fail in late-stage clinical tests.

Tao also believes his nanopolymers could better deliver drugs to their targets. Since they are nanosized and water soluble, the nanopolymers could gain access to cells more effectively than a standalone drug that is only minimally water-soluble.

Tao demonstrated the nanopolymer's abil
'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Drought-exposed leaves adversely affect soil nutrients, study shows
2. Protein adaptation shows that life on early earth lived in a hot, acidic environment
3. Epidemiological tree study shows impacts of climate change on forests
4. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
5. Closer look at cell membrane shows cholesterol keeping order
6. New study shows you can have your candy and eat it too -- without adverse health effects
7. Study shows hunger hitting closer to home
8. GPS study shows wolves more reliant on a cattle diet
9. Russian boreal forests undergoing vegetation change, study shows
10. Research shows not only the fittest survive
11. Study shows living at high altitude reduces risk of dying from heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanopolymer shows promise for helping reduce cancer side effects
(Date:9/15/2014)... of Science and Technology in Society in the College ... has won a 2014 National Science Foundation Faculty Early ... of creating a global nuclear emergency response plan. , ... Plant in March 2011 was a turning point in ... Three of the plant,s six nuclear reactors melted down ...
(Date:9/15/2014)... For multicellular lifeplants and animalsto thrive in the ... the water. In certain coastal areas, extreme oxygen-starvation ... destroy food web structure. As dissolved oxygen levels ... life into microbial community metabolism resulting in impacts ... , Over the past 50 years, oxygen minimum ...
(Date:9/15/2014)... and cognitive function may play roles in one,s musical ... pitch, timbre, tone durations, and formal structure in music. ... explain that extremes in musical aptitude (extreme capacity/no capacity) ... individuals having moderate aptitude. , "This is a typical ... genes, and it is influenced to varying degrees by ...
Breaking Biology News(10 mins):'Nuclear disasters don't respect national boundaries' 2Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5
... Sommerlad has thought a lot about the challenges of ... engineering at Newark College of Engineering in 1960. He,s ... power-plant technologies needed to produce the electricity that sustains ... recent recipient of one of six NJIT Alumni Achievement ...
... American Societies for Experimental Biology (FASEB) Minority Access to ... recipients for the 2011 Annual Biomedical Research Conference for ... November 9-12, 2011. These awards are meant to ... scientists into the mainstream of the basic science community ...
... - Although exercise is generally considered to be a ... has traditionally been considered too risky for women who ... benefits such as decreasing the risk of women developing ... high levels but how this might happen has remained ...
Cached Biology News:NJIT alum, power expert, advisor during Exxon/Valdez clean-up, gets award 2NJIT alum, power expert, advisor during Exxon/Valdez clean-up, gets award 3MARC Travel awards announced for the ABRCMS meeting 2MARC Travel awards announced for the ABRCMS meeting 3MARC Travel awards announced for the ABRCMS meeting 4MARC Travel awards announced for the ABRCMS meeting 5Exercise before and during early pregnancy increases two beneficial proteins for mothers-to-be 2
(Date:9/16/2014)... 2014 BCC Research reveals in ... CELLS , the global market for stem cells is ... with a five-year compound annual growth rate (CAGR) of ... Americas with growth projections of $2.2 billion in 2014 ... http://photos.prnewswire.com/prnh/20140805/700528) , Unlike other potential applications of ...
(Date:9/15/2014)... , Sept. 15, 2014   Global ... innovator of scientific products and services for satellite ... Acquisition Solution for Integrated Services (OASIS) from the ... GST was selected to provide the government best-value ... Small Business (SB) category in Pool 4. The ...
(Date:9/15/2014)... from North Carolina State University have developed a technique ... applying very low voltages, opening the door to a ... technologies. The technique hinges on the fact that the ... deposited or removed acts as a surfactant, lowering ... fluid. , The researchers used a liquid metal alloy ...
(Date:9/15/2014)... (PRWEB) September 15, 2014 Bioptigen ... deep imaging OCT system for the optical device metrology ... EnvisuTM S4410 SDOCT for Contact Lens Metrology ... standard and high complexity contact lens, IOL structures, and ... of a complete contact lens immersed in a hydration ...
Breaking Biology Technology:Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 2Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 3Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3Researchers control surface tension to manipulate liquid metals 2Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2
... media presentations created with Sonic Foundry s Mediasite ... of hosted services, which help organizations capture presentations digitally and ... service platform created exclusively for Mediasite, the companies announced in ... any size and type can leverage the power of rich ...
... Formulatrix Inc. and Bruker AXS ... protein-crystal incubation and imaging products. , ,Crystal Farm, developed ... Partners International , is an integrated product for incubation ... companies design drugs. The system will now work with ...
... the first installment - From the mind to ... - The Wisconsin Technology Council has published ... 24-page publication highlights the states research base, technology-transfer process, ... I-Q Corridor that joins Chicago, Wisconsin and Minneapolis-St. Paul. ...
Cached Biology Technology:BxVideo designs Web hosting service for Sonic Foundry media presentations 2Protein-crystal companies join forces for better imaging process 2WTC launches Wisconsin Life Science magazine 2
... monoclonal antibody development to targets including proteins ... DNA, and cancer-specific surface antigens. A&Gs ... is completed in approximately 40 days (duration ... of antigens). Phase I: Immunization, test ...
PCR System for increased fidelity, yield and length of PCR products. Amplifies targets up to 10 kb from human genomic DNA....
...
US Pharmacopoeia Purified-Water/Water-for-Injection Quality Water...
Biology Products: