Navigation Links
Nanopolymer shows promise for helping reduce cancer side effects
Date:4/5/2011

WEST LAFAYETTE, Ind. - A Purdue University biochemist has demonstrated a process using nanotechnology to better assess whether cancer drugs hit their targets, which may help reduce drug side effects.

W. Andy Tao, an associate professor of biochemistry analytical chemistry, developed a nanopolymer that can be coated with drugs, enter cells and then removed to determine which proteins in the cells the drug has entered. Since they're water-soluble, Tao believes the nanopolymers also may be a better delivery system for drugs that do not dissolve in water effectively.

"Many cancer drugs are not very specific. They target many different proteins," said Tao, whose findings were published in the early online in the journal Angewandte Chemie International Edition. "That can have a consequence - what we call side effects."

In addition to the drug, the synthetic nanopolymer is equipped with a chemical group that is reactive to small beads. The beads retrieve the nanopolymer and any attached proteins after the drug has done its work. Tao uses mass spectrometry to determine which proteins are present and have been targeted by the drug.

Knowing which proteins are targeted would allow drug developers to test whether new drugs target only desired proteins or others as well. Eliminating unintended protein targets could reduce the often-serious side effects associated with cancer drugs.

Tao said there currently is no reliable way to test drugs for off-targeting. He said drugs are often designed to inhibit or activate the function of a biomolecule associated with cancer, but those drugs tend to fail in late-stage clinical tests.

Tao also believes his nanopolymers could better deliver drugs to their targets. Since they are nanosized and water soluble, the nanopolymers could gain access to cells more effectively than a standalone drug that is only minimally water-soluble.

Tao demonstrated the nanopolymer's abilities using human cancer cells and the cancer drug methotrexate. The nanopolymers were tracked using a fluorescent dye to show they were entering cells. Then, Tao broke the cells and retrieved the nanopolymers.

Tao has shown the nanopolymer's ability using a metabolic drug, which are small, low-cost drugs but are less target specific and have more side-effects. He now plans to do the same using drugs that are based on synthetic peptides, which are larger and more expensive but more specific and with fewer side effects.


'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

Related biology news :

1. Drought-exposed leaves adversely affect soil nutrients, study shows
2. Protein adaptation shows that life on early earth lived in a hot, acidic environment
3. Epidemiological tree study shows impacts of climate change on forests
4. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
5. Closer look at cell membrane shows cholesterol keeping order
6. New study shows you can have your candy and eat it too -- without adverse health effects
7. Study shows hunger hitting closer to home
8. GPS study shows wolves more reliant on a cattle diet
9. Russian boreal forests undergoing vegetation change, study shows
10. Research shows not only the fittest survive
11. Study shows living at high altitude reduces risk of dying from heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanopolymer shows promise for helping reduce cancer side effects
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/20/2017)... -- PMD Healthcare announces the release of its new ... (WMS), a remote, real-time lung health monitoring and management ... a Medical Device, Digital Health, and Chronic Care Management ... solutions that empower people to improve their healthcare and ... the first ever personal spirometer, Spiro PD, which was ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... 20, 2017  Kibow Biotech Inc., a pioneer in ... issuance of a new patent covering a unique method ... U.S. Patent and Trademark Office on May 23 rd ... Buzz of Bio award in 2014 in ... non-drug approaches to chronic disease. Renadyl™, the first and ...
(Date:6/19/2017)... ... June 19, 2017 , ... As Vice President, Product Services, ... training, implementation, support, and client process and SOP development. , Mr. Guinter brings ... leadership roles for service providers and top-tier pharmaceuticals, and as an independent consultant ...
(Date:6/16/2017)... ... June 16, 2017 , ... Cognition Corporation , ... two more sessions of its “From the Helm” Webinar Series. , The ... online templates for design control exercises. Led by David Cronin, Cognition’s CEO, the ...
(Date:6/15/2017)... ... June 15, 2017 , ... Cybrexa ... Series B round of financing in the amount of $6 million. An investment ... participated in the round. , The Series B funding will enable Cybrexa to ...
Breaking Biology Technology: