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Nanoparticles used in common household items caused genetic damage in mice
Date:11/16/2009

oxicity, possibly caused by a secondary mechanism associated with inflammation and/or oxidative stress. Given the growing use of these nanoparticles, these findings raise concern about potential health hazards associated with exposure."

The manufacture of TiO2 nanoparticles is a huge industry, Schiestl said, with production at about two million tons per year. In addition to paint, cosmetics, sunscreen and vitamins, the nanoparticles can be found in toothpaste, food colorants, nutritional supplements and hundreds of other personal care products.

"It could be that a certain portion of spontaneous cancers are due to this exposure," Schiestl said. "And some people could be more sensitive to nanoparticles exposure than others. "I believe the toxicity of these nanoparticles has not been studied enough."

Schiestl said the nanoparticles cannot go through skin, so he recommends using a lotion sunscreen. Spray-on sunscreens could potentially be inhaled and the nanoparticles can become lodged in the lungs.

The mice were exposed to the TiO2 nanoparticles in their drinking water and began showing genetic damage on the fifth day. The human equivalent is about 1.6 years of exposure to the nanoparticles in a manufacturing environment. However, Schiestl said, it's not clear if regular, everyday exposure in humans increases exponentially as continued contact with the nanoparticles occurs over time.

"These data suggest that we should be concerned about a potential risk of cancer or genetic disorders especially for people occupationally exposed to high concentrations of titanium dioxide nanoparticles, and that it might be prudent to limit their ingestion through non-essential drug additives, food colors, etc.," the study states.

Next, Schiestl and his team will study exposure to the nanoparticles in mice that are deficient in DNA repair, to perhaps help find a way to predict which people might be particularly sensitive to them
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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

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