Navigation Links
Nanoparticles used in common household items caused genetic damage in mice
Date:11/16/2009

Titanium dioxide (TiO2) nanoparticles, found in everything from cosmetics to sunscreen to paint to vitamins, caused systemic genetic damage in mice, according to a comprehensive study conducted by researchers at UCLA's Jonsson Comprehensive Cancer Center.

The TiO2 nanoparticles induced single- and double-strand DNA breaks and also caused chromosomal damage as well as inflammation, all of which increase the risk for cancer. The UCLA study is the first to show that the nanoparticles had such an effect, said Robert Schiestl, a professor of pathology, radiation oncology and environmental health sciences, a Jonsson Cancer Center scientist and the study's senior author.

Once in the system, the TiO2 nanoparticles accumulate in different organs because the body has no way to eliminate them. And because they are so small, they can go everywhere in the body, even through cells, and may interfere with sub-cellular mechanisms.

The study appears this week in the journal Cancer Research.

In the past, these TiO2 nanoparticles have been considered non-toxic in that they do not incite a chemical reaction. Instead, it is surface interactions that the nanoparticles have within their environment- in this case inside a mouse - that is causing the genetic damage, Schiestl said. They wander throughout the body causing oxidative stress, which can lead to cell death.

It is a novel mechanism of toxicity, a physicochemical reaction, these particles cause in comparison to regular chemical toxins, which are the usual subjects of toxicological research, Schiestl said.

"The novel principle is that titanium by itself is chemically inert. However, when the particles become progressively smaller, their surface, in turn, becomes progressively bigger and in the interaction of this surface with the environment oxidative stress is induced," he said. "This is the first comprehensive study of titanium dioxide nanoparticle-induced genot
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Behavior modification could ease concerns about nanoparticles
2. Knocking nanoparticles off the socks
3. Clemson bioengineer uses nanoparticles to target drugs
4. Therapeutic nanoparticles give new meaning to sugar-coating medicine
5. Carbon nanoparticles toxic to adult fruit flies but benign to young
6. New insights into health and environmental effects of carbon nanoparticles
7. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
8. University of Leicester researchers discover new fluorescent silicon nanoparticles
9. New nanoparticles could revolutionize therapeutic drug discovery
10. Shape matters in the case of cobalt nanoparticles
11. To fight drug addiction, UB researchers target the brain with nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2015)... , Feb. 12, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... provisional patent 62/113114 for DISTRIBUTED METHOD AND ... The patent further establishes NXT-ID,s position in the ... property portfolio the ability for multiple devices to collaborate ...
(Date:2/5/2015)... , Feb. 5, 2015  Marken is starting its ... and has launched a new marketing campaign to solidify ... (CLO).  The new campaign focuses on First ... and shipments. The first headline in the ... Marken,s priorities with its client,s priorities. Marken recognizes the ...
(Date:2/5/2015)... OXFORD, Conn. , Jan. 28, 2015 ... ("NXT-ID" or the "Company"), a biometric authentication company focused ... present at the upcoming RedChip Global Online CEO Conference ... Gino Pereira , CEO of ... discussing its lead product, the Wocket smart wallet and ...
Breaking Biology News(10 mins):NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Marken Launches New Patient-Centric Campaign 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3
... foot ulcers are a common problem for diabetics and are ... leg amputations in these patients. There is currently no effective ... new research offers hope. French researchers found that diabetic ... prolinespecific molecules found in proteinshowed better wound healing over rats ...
... of the species that inhabit the world,s oceans may remain ... species have been described in the last decade than in ... November 15 in the Cell Press publication Current Biology ... of the worlda massive collaborative undertaking by hundreds of experts ...
... college-age video game enthusiasts teach young surgeons-in-training? ... University of Texas Medical Branch at Galveston (UTMB) ... the superior hand-eye coordination and hand skills gained ... needed to perform today,s most technologically-advanced robotic surgeries. ...
Cached Biology News:Arginine and proline enriched diet may speed wound healing in diabetes 2At least one-third of marine species remain undescribed 2Young gamers offer insight to teaching new physicians robotic surgery 2Young gamers offer insight to teaching new physicians robotic surgery 3
(Date:2/26/2015)... TORONTO , Feb. 26, 2015 /PRNewswire/ - SQI ... SQIDF), a life sciences company that develops and commercializes ... reported its financial and operational results for the fiscal ... this press release are in Canadian dollars (CAD), unless ... Company continued to win new business from our existing ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015   Regulus ... biopharmaceutical company leading the discovery and development of innovative ... Xanthopoulos , Ph.D., President and Chief Executive Officer of ... and Company 35 th Annual Healthcare Conference on ... conference is being held at the Boston Marriott Copley ...
(Date:2/26/2015)... DuPont Executive Vice President James C. ... advancements and product launches across the Agriculture and Nutrition ... Lynch 2015 Global Agriculture Conference. "While ... the last two years, long-term demand for agricultural production ... last decade, when demand for corn and soybeans increased ...
(Date:2/26/2015)... NJ (PRWEB) February 26, 2015 On ... and its affiliated companies, Wilentz, Goldman & Spitzer, ... a trade secrets lawsuit against Genewiz Inc. in excess ... obtained and utilized GenScript’s trade secrets, and that it ... The court entered an order denying motions for judgment ...
Breaking Biology Technology:SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3
... AstraZeneca (NYSE:,AZN) today announced that the U.S. Food ... (quetiapine fumarate) Extended-Release,Tablets for the acute treatment of ... and mixed episodes associated with bipolar I,disorder, and ... adjunctive,therapy to lithium or divalproex. SEROQUEL XR is ...
... ENMD ) a clinical-stage pharmaceutical company developing,therapeutics ... today that Thomas H. Bliss, Jr., EntreMed,s Senior ... Company,overview at the 16th Annual BioPartnering Europe Conference, ... United Kingdom. Mr. Bliss, presentation,is scheduled for Monday, ...
... - Ranked Number 7 out of top 20 ... division of Merck KGaA, Darmstadt, Germany, announced,today that it ... employer in the,biotechnology and pharmaceutical industries, ranking number 7 ... "We are honored that the scientific community has ...
Cached Biology Technology:FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 2FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 3FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 4FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 5FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 6FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 7FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 8FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 9EntreMed to Present at BioPartnering Europe Conference 2EntreMed to Present at BioPartnering Europe Conference 3Merck Serono Named as a Top Employer by Science Magazine 2
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Rabbit polyclonal to Dishevelled 2 ( Abpromise for all tested applications). entrezGeneID: 1856 SwissProtID: O14641...
... Polyclonal Antibody to Asb-2 (Ankyrin repeat and ... raised against synthetic peptides containing amino acids ... Human spleen lysate (Imgenex Catalog No. 40149) ... It should cross react with mouse and ...
Biology Products: