Says Anderson, "Despite barrier creams, anti-inflammatory drugs, and attempts to avoid nickel, this [metal] is still the most common cause of allergic skin reactions. Nanoparticles that bind to [the nickel] allergens but do not penetrate the skin offer a new strategy. Big hope in a small package!"
"We expect that a person could simply apply the cream just as they would hand cream," says Praveen Kumar Vemula of BWH, HMS, HSCI, and HST. Vemula is first author of the paper.
Toward a Solution
The idea for tackling the problem began when Karp, a specialist on nanoparticles, met Anderson at a dinner. Afterward, Karp sat at his computer thinking about how he could potentially work with the accomplished dermatologist to tackle medical problems. As he pondered, he looked at his hands, which were red and itchy from his nickel allergy. Could he and Anderson find a nontoxic, practical way to prevent nickel from penetrating the skin using nanoparticles?
The team began by focusing on compounds containing calcium, which are known to sequester nickel (some are used in the treatment of water). Next, they explored whether these compounds were available as nanoparticles. Karp knew that the tiny particles could potentially allow very efficient nickel capture thanks to their very high surface area.
The team limited their search to nanoparticles within a certain size range. "We wanted them to be large enough so they could not penetrate the skin, yet small enough to present a very large surface area for capturing nickel," Vemula says. (They ultimately decided on particles between 70 and 500 nanometers.) Finally, to
|Contact: Holly Brown-Ayers|
Brigham and Women's Hospital