Navigation Links
Nanoparticles added to platelets double internal injury survival rate
Date:8/20/2012

Naonparticles tailored to latch onto blood platelets rapidly create healthy clots and nearly double the survival rate in the vital first hour after injury, new research shows.

"We knew an injection of these nanoparticles stopped bleeding faster, but now we know the bleeding is stopped in time to increase survival following trauma," said Erin Lavik, a professor of biomedical engineering at Case Western Reserve University and leader of the effort.

The researchers are developing synthetic platelets that first responders and battlefield medics could carry with them to stabilize car crash or roadside bomb victims. An injection could slow or halt internal bleeding until the victim reaches a hospital and receives blood transfusions and surgery.

Lavik spoke about the latest breakthroughs in her research today at the American Chemical Society's annual meeting in Philadelphia.

Lavik and her colleagues began focusing on synthetic platelets after learning the military has no equivalent of a tourniquet, pressure dressing or other easily transportable technology to stem bleeding from internal injuries.

But as they explored possible applications, they recognized that the approach is widely needed beyond military conflict. Traumatic injury is the leading cause of death for people age 4 to 44, often overwhelming the body's natural blood-clotting process.

The platelet-like nanoparticles are made of biodegradable polymers used in devices already approved by the Food & Drug Administration for use in humans. They're designed to hone in on injuries after injection. Natural platelets, activated by injury, emit chemicals that bind natural platelets and the additional synthetics into a larger clot faster than natural platelets alone.

Tested on a lethal liver injury model in lab rats, the one-hour survival rate of the models injected with the nanoparticles was 80 percent. For control groups treated with saline alone the su
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Are silver nanoparticles harmful?
2. Hybrid copper-gold nanoparticles convert CO2
3. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
4. From pomegranate peel to nanoparticles
5. Palladium-gold nanoparticles clean TCE a billion times faster than iron filings
6. Paints and coatings containing bactericidal agent nanoparticles combat marine fouling
7. Oh, my stars and hexagons! DNA code shapes gold nanoparticles
8. Fish oil added to yogurt may help consumers meet daily nutritional requirements
9. Virginia Tech announces 2012 football helmet ratings; 2 more added to the 5-star mark
10. UC Santa Barbara researchers develop synthetic platelets
11. Green Oakley Cluster to double OSC computing power
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2014)... one of the first U.S. outbreaks of the H1N1 ... some 2,000 people. A university math and biology professor ... time to gain insight into how only a few ... the university community., The fall 2009 semester hadn,t even ... university,s Health and Wellness Services clinic11 one day, and ...
(Date:8/25/2014)... of substances known as endocrine disrupting chemicals (EDCs), ... pass from one generation to the next, but ... to EDC may show especially adverse reactions to ... researchers from The University of Texas at Austin ... are affected differently by ancestral exposure to a ...
(Date:8/25/2014)... by manipulating the behavior of ants emits a ... of its natural target host, but not when ... The findings, which suggest that the fungus "knows" ... molecular mechanisms underlying this phenomenon, according to researchers., ... secrete chemicals that affect their environment," noted lead ...
Breaking Biology News(10 mins):WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3Exposure to toxins makes great granddaughters more susceptible to stress 2Zombie ant fungi 'know' brains of their hosts 2Zombie ant fungi 'know' brains of their hosts 3
... In the five months since passage of the ... of research-related awards have been made, supporting important scientific ... increase in basic research funding in American history - ... scientific research and education projects, while $3.5 billion is ...
... 30, 2009) A team of 80 researchers from ... Shifting Sands: Environmental and Cultural Change in Maryland,s Coastal ... barrier islands making up Maryland,s Atlantic coastline. Published ... the history, setting, context and ecology of these waterways, ...
... from the talents of Rembrandt, Van Gogh and other ... of colors on a palette. In a similar manner, ... (NIST) have created an innovative device called the "microfluidic ... concentration across an areain a miniature chamber about the ...
Cached Biology News:'Microfluidic palette' may paint clearer picture of biological processes 2
(Date:8/26/2014)... Mich. , Aug. 26, 2014   ... development of breakthrough oral medicines to treat autoimmune ... immune modulation, today announced the appointment of ... company,s scientific advisory board.  Dr. Singh will lead ... to advance Lycera,s multiple ongoing research programs and ...
(Date:8/26/2014)... , Aug. 26, 2014 Trovagene, ... Next Generation Dx Summit; Moving Assays to the ... Detection and Monitoring of Cell Free Tumor DNA ... analytical component of its Precision Cancer Monitoring (PCM) ... clinical sensitivity for the detection of tumor DNA ...
(Date:8/26/2014)... (PRWEB) August 26, 2014 InstantGMP, Inc., ... processes, implemented a new pricing structure with increased user ... with cGMP and 21 CFR Part 11 requirements. , ... Practices any way we can” said Rick Soltero, President ... of available users allowed customers to have separate accounts ...
(Date:8/26/2014)... 26, 2014 Spartan Bioscience today ... Director of Business Development. Mr. Shah is responsible ... CYP2C19 System in the United States and ... business opportunities and strategic initiatives for the company’s ... Spartan, Mr. Shah was the Global Marketing Product ...
Breaking Biology Technology:Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 4Spartan Bioscience Names Charudutt Shah as Director of Business Development 2
... Market Research, a global provider of pharmaceutical competitive intelligence ... "Thought Leader Insight & Analysis: Alzheimer,s Disease," designed to ... with a stake in the market for diagnostics and ... ). , , MedPredict interviewed ...
... ... On-Site at Komen Western New York Race for the Cure® , ... Ottawa, ON (PRWEB) June 12, 2009 -- DNA Genotek , a ... Roswell Park Cancer Institute (RPCI) to collect DNA saliva samples on-site at the Susan ...
... ... biofuels could be entering the tanks of aircraft, according to the Geneva-based Air Transport Action ... this "new age in flight", the group this week launches a new publication, The Beginner,s ... ...
Cached Biology Technology:New MedPredict Report Reveals Top Alzheimer's Experts' Insights on Diagnostics and Treatments in Development Pipeline 2DNA Genotek Partners with Roswell Park Cancer Institute to Accelerate Breast Cancer Research 2DNA Genotek Partners with Roswell Park Cancer Institute to Accelerate Breast Cancer Research 3Welcome to the Biofuel Age of Flight 2Welcome to the Biofuel Age of Flight 3
... particle based purification systems provide high speed ... sample. They offer increased throughput and reproducible ... KingFisher, KingFisher mL and KingFisher 96, covering ... Each system consists of an instrument, specially ...
... engineered for efficient drying down of synthetic ... cover and a post-trap with ammonia neutralizing ... of samples in ammonium hydroxide., , ... , Comes standard with ...
... Thermo Savant SpeedVac™ Concentrators set the standard ... series SC210A SpeedVac with large chamber uses a ... dry multiple samples in a single run. , ... Rotor Chamber for long lasting chemical compatibility ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
Biology Products: