Navigation Links
Nanoparticle pinpoints blood vessel plaques
Date:2/6/2014

centrates imaging agents on plaques.

The research team includes: Michael A. Bruckman, a postdoctoral researcher, and Lauren N. Randolph, an undergraduate student, in the Steinmetz lab; Kai Jiang, a PhD student in Yu's lab; and Leonard G. Luyt, assistant professor, and Emily J. Simpson, a PhD candidate, both at department of chemistry at Western University, in London, Ontario.

Elongated nanoparticles have a higher probability of being pushed out of the central blood flow and targeting the vessel wall compared to spheres. Further the shape allows more stable attachment to the plaque, the researchers said.

The virus surface is modified to carry short chains of amino acids, called peptides, that make the virus stick where plaques are developing or already exist. Luyt and Simpson synthesized the peptides.

"The binding allows the particle to stay on the site longer, whereas the sheer force is more likely to wash away a sphere, due to its high curvature," said Yu, an appointee of the Case School of Engineering.

The virus surface was also modified to carry near-infrared dyes used for optical scanning, and gadolinium ions (which are linked with organic molecules, to reduce toxicity of the metal) used as an MRI contrasting agent. They used optical scans to verify the MRI results.

By loading the surface with gadolinium ions instead of injecting them and letting them flow freely in the blood stream, the nanoparticle increases the relaxivityor contrast from healthy tissueby more than four orders of magnitude.

"The agent injected in the blood stream has a relaxivity of 5, and our nanoparticles a relaxivity of 35,000," said Steinmetz who was appointed by the Case Western Reserve School of Medicine.

That's because the nanorod carries up to 2,000 molecules of the contrast agent, concentrating them at the plaque sites. Secondly, attaching the contrast agent to a nanoparticle scaffold reduces its molecular tumb
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UT Arlington bioengineer to create new nanoparticle system to shore up arterial walls
2. Gold nanoparticles help to develop a new method for tracking viruses
3. A magnetic nanoparticles-based method for DNA extraction from the saliva after stroke
4. Oregon scientists offer new insights on controlling nanoparticle stability
5. Ultrasound, nanoparticles may help diabetics avoid the needle
6. Nanoparticles can overcome drug resistance in breast cancer cells
7. Making complex nanoparticles easily reproducible
8. Gold nanoparticles give an edge in recycling CO2
9. Stealth nanoparticles lower drug-resistant tumors defenses
10. Researchers figure out why gold nanoparticles can penetrate cell walls
11. Nanoparticles, pH phoresis could improve cancer drug delivery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... "human activities in this area of the world have contributed ... grown for use as a cooking oil and biofuel, while ... the most widely produced edible oil in the world, and ... soybean oil. , The environmental effects of such growth have ... crop, and the preferred method is fire. The clearing often ...
(Date:9/29/2014)... MADISON, Wis. Mountain pine beetles get a bad ... for killing pine trees over tens of millions of ... last decade. , But contrary to popular belief, ... severe wildfires like those that have recently swept through ... role in the ecological severity of fires than these ...
(Date:9/29/2014)... (Boston) A review article published online in ... that happen in the brain as a result of ... the sleep cycle. , Clinical assessments and research ... from severely disrupted sleep. This can occur when people ... or when they are abstaining. , "Sleep-wake disturbances ...
Breaking Biology News(10 mins):Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... MAYWOOD, Ill. -- Most people know that too much sodium ... suggests that people trying to lower their blood pressure should ... effect to sodium. Researchers found that the ratio of ... cardiovascular disease than sodium or potassium alone. "There ...
... millions of genetic mutations has revealed four new DNA "hotspots" ... researchers led by the University of Michigan and including several ... in a just-published study. Appearing Jan. 25 in ... two other previously identified DNA sites, discovered by researchers at ...
... press release is available in French . ... study conducted by Universit de Montral researchers on ... treatment plant has revealed the presence of chemotherapy ... Bezafibrate (cholesterol reducing medication), enalapril (hypertension medication), methotrexate ...
Cached Biology News:Cutting salt isn't the only way to reduce blood pressure 2Researchers identify 4 genetic hotspots associated with psoriasis 2Researchers identify 4 genetic hotspots associated with psoriasis 3Hypertension and cholesterol medications present in water released into the St. Lawrence River 2
(Date:9/30/2014)... The overall research objective was to ... and use. Most researchers outsource NGS technologies; however, ... within the next 12 months. Data accuracy and ... sequencing instruments. Disease-related research is the dominant use ... to surge, with half of the respondents planning ...
(Date:9/30/2014)... 2014 Rainbow Scientific, Inc. (RSI), ... recently opened an online store to add customer ... lines developed and manufactured by Biological Industries, Inc. ... Biological Industries’ Nutristem® serum-free, xeno-free reagents for human ... cell (hESC) culture. , The online store ...
(Date:9/30/2014)... 30, 2014 Back in the 1970’s, many ... feet. per employee, which included space for circulation and file ... Jeff Howell, partner at Nidea Corporate Real Estate / ... “By the year 2000, however, 250 square feet per ... number come down to 175 to 225 square feet, and ...
(Date:9/29/2014)... the start of the military conflicts in Iraq and ... United States with traumatic brain injury caused by exposure ... improvised explosive devices, or IEDs. Symptoms of traumatic brain ... headaches and nausea, to more severe impairments in memory ... of Defense has recognized the critical importance and complexity ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... SAN DIEGO, Sept. 24 Neurocrine Biosciences,Inc. (Nasdaq: ... the UBS Global Life Sciences Conference. The live presentation,will ... Eastern Time,(ET) /5:30 a.m. Pacific Time (PT). The presentation ... Company,s website at, http://www.neurocrine.com If you are ...
... Available Only through Professionals, New Immuno-Skin Complex(TM) Targets ... to Fight the Causes of Skin Aging, EL ... his,credit including professional esthetic treatments utilizing AHA,s, and the,category ... of Medicine at UCLA, founder of Murad Inc. and ...
... Inc., a leading developer of advanced medical devices ... J. Daniel,Cole as the company,s new Chairman of ... partner with Spray Venture Partners, a venture,capital firm ... brings twenty years of medical device operational experience,having ...
Cached Biology Technology:Murad Boosts Skin Immunity With the New Murad(R) Professional Line 2OmniSonics Appoints J. Daniel Cole Chairman of the Board 2
... The biolistic PDS-1000 He system ... gas to accelerate micron-size nucleic acid-coated ... necessary to transfect cells, tissues, or ... the cell surface. The system includes ...
Sf21 Insect Cells (Frozen) in Max-XP Medium...
... is used for conventional PCR and thermal ... personal thermal cycler, which features a 96-well ... tubes or plates, programmable time, temperature, and ... modes of temperature control. The system also ...
... with colony-picking capabilities, 110-120 V, uses floating ... oligonucleotides, carbohydrates, lipids, and other biomolecules onto ... This system can also be used for ... in diameter and for inoculating 96- or ...
Biology Products: