Navigation Links
Nanoparticle-based battlefield pain treatment moves a step closer
Date:9/24/2009

Ann Arbor, Mich. University of Michigan scientists have developed a combination drug that promises a safer, more precise way for medics and fellow soldiers in battle situations to give a fallen soldier both morphine and a drug that limits morphine's dangerous side effects.

They use nanotechnology to devise ultra-small polymer particles capable of carrying the drugs into the body. The development of the combination drug makes possible a precise feedback system that can safely regulate release of the drugs aboard the nanoparticles.

The scientists at the Michigan Nanotechnology Institute for Medicine and Biological Sciences report their results in the September issue of Bioorganic & Medicinal Chemistry Letters.

Context

Soldiers injured in combat typically receive morphine as soon as possible to relieve pain. Morphine, however, also depresses normal breathing and blood pressure, sometimes to life-threatening levels. So medics need to give a short-acting drug that aids normal respiration and heart beat, but in doses that still allow the morphine to relieve pain effectively. Today, achieving that balance is a challenge outside a hospital.

The combination drug that U-M scientists have developed promises to make balanced treatment possible even in combat zones, says James R. Baker, Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences (MNIMBS) and the study's senior author.

"This system could improve pain management for millions of patients with chronic illnesses," says Baker, Ruth Dow Doan Professor and allergy division chief in the U-M Department of Internal Medicine.

The long-range goal of the research, funded by the U.S. Defense Advanced Research Projects Agency, is to develop a practical method that medics or soldiers themselves could administer, perhaps using an auto-injector device.

Research details

U-M chemists screened se
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Trial of new treatment for advanced melanoma shows rapid shrinking of tumors
2. Rethinking Alzheimers disease and its treatment targets
3. Diabetes drug kills cancer stem cells in combination treatment in mice
4. UCF discovery could open door to obesity, diabetes treatments
5. Mothers immune system may block fetal treatments for blood diseases
6. Protein handlers should be effective treatment target for cancer and Alzheimers
7. Experimental treatment halts hypoxic-ischemic brain injury in newborns
8. Discovery to aid in future treatments of third-world parasites
9. ISU researchers find possible treatment for spinal muscular atrophy
10. Promising new treatment for Alzheimers suggested based on Hebrew University research
11. New technique can fast-track better ionic liquids for biomass pre-treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... 21, 2014) -- There are all sorts of signaling ... spread their colorful tails; satin bowbirds build specialized stick ... shiny objects; and European bitterling males show off bright ... a unique method to communicate with others. , ... "Signaling can have profound fitness implications for individuals that ...
(Date:4/22/2014)... HOUSTON (April 22, 2014) Biotechnology scientists must ... for new patent and licensing guidelines, according to a ... Policy. , Published in the current issue of the ... on the June 2013 U.S. Supreme Court ruling in ... Genetics that naturally occurring genes are unpatentable. The court ...
(Date:4/22/2014)... organizations have presented Beaumont Health System with prestigious, ... from both athletic and nonathletic injuries. , ... a $40,000 grant to fund stem cell-based research ... like a ruptured knee anterior cruciate ligament, or ... "An anterior cruciate ligament injury is the over-stretching ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3Beaumont awarded grants to study sports-related injury treatment, improve recovery 2
... A new Cornell study finds that serving children combined snacks of ... and be just as satisfied as those who were served ... they take longer to eat than potato chips. This is ... less," said Brian Wansink, professor of marketing at the Charles H. ...
... is available in German . Multidrug-resistant ... worldwide. Propagation of bacterial resistance is alarming and makes the ... Planck Institute for Biophysical Chemistry in Gttingen have now identified ... EF-P plays a crucial role in the production of proteins ...
... Spanish . , The U.S. Department ... (DOD) have joined forces to create effective barriers and ... Scientists at the Agricultural Research Service (ARS) ... Gainesville, Fla., are evaluating insecticides, testing pesticide application equipment, ...
Cached Biology News:Combo-snacks of cheese and vegetables cut kids calories 2Achilles' heel of pathogenic bacteria discovered 2Achilles' heel of pathogenic bacteria discovered 3Arming US troops with insect-protective gear 2
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... IL (PRWEB) January 15, 2014 Look ... find hard-working items for the lab, from fluid handling ... Guaranteed-in-Stock (GIS)—ready to ship when you order. , ... Peristaltic Pumps , from the L/S® model for precise ...
(Date:1/15/2014)... Jan. 15, 2014 ­ RedBrick Health , a ... technology, today announces that EmblemHealth , the ... company, is now providing the RedBrick Compass health assessment, ... to all of its members. EmblemHealth is among the ...
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... director of the Division of Information Technology (DOIT) at ... for information technology leadership from the national organization ... and ground-breaking leadership in the information technology business since ... , ,A co-founder and executive director of the Northern ...
... Wis. -- The National Institute for General Medical Sciences ... SBIR Phase II grant, while the National Cancer Institute ... grant, the Madison-based company reported Thursday. , ,The General ... optimization and validation of a fluorescent HTS assay for ...
... Good news for some of Madisons emerging technology ... week. These investments and grants will help to ... Alfalight, a UW-Madison spinout company that manufacturers ... nearly $6 million in military funding. Meanwhile, another ...
Cached Biology Technology:BellBrook Labs gets major research funding 2
... PCR carry-over contamination, which prevents false ... products from previous PCR amplifications without ... improves amplification ,Optimized for use with ... instrument systems , The GeneAmp PCR ...
... that catalyzes the hydrolysis of,starch to ... dextrins. The,level of a-amylase in various ... of,clinical significance in the diagnosis of ... and microbial a-amylases are,important enzymes for ...
... The Thermo Labsystems Wellmix is a ... and time settings. The shaking speed is ... shaking frequency, high speed and a small ... assays. The shaking time is quick and ...
Rabbit polyclonal to STUB1 ( Abpromise for all tested applications). entrezGeneID: 10273 SwissProtID: Q9UNE7...
Biology Products: