Navigation Links
Nanomodified surfaces seal leg implants against infection
Date:3/22/2011

PROVIDENCE, R.I. [Brown University] In recent years, researchers have worked to develop more flexible, functional prosthetics for soldiers returning home from battlefields in Afghanistan or Iraq with missing arms or legs. But even new prosthetics have trouble keeping bacteria from entering the body through the space where the device has been implanted.

"You need to close (the area) where the bacteria would enter the body, and that's where the skin is," said Thomas Webster, associate professor of engineering and orthopaedics at Brown University.

Webster and a team of researchers at Brown may have come across the right formula to deter bacterial migrants. The group reports two ways in which it modified the surface of titanium leg implants to promote skin cell growth, thereby creating a natural skin layer and sealing the gap where the device has been implanted into the body. The researchers also created a molecular chain to sprinkle skin-growing proteins on the implant to hasten skin growth.

The findings are published in the Journal of Biomedical Materials Research A.

The researchers, including Melanie Zile, a Boston University student who worked in Webster's lab as part of Brown's Undergraduate Teaching and Research Awards program, and Sabrina Puckett, who earned her engineering doctorate last May, created two different surfaces at the nanoscale, dimensions less than a billionth of a meter.

In the first approach, the scientists fired an electron beam of titanium coating at the abutment (the piece of the implant that is inserted into the bone), creating a landscape of 20-nanometer mounds. Those mounds imitate the contours of natural skin and trick skin cells into colonizing the surface and growing additional keratinocytes, or skin cells.

Webster knew such a surface, roughened at the nanoscale, worked for regrowing bone cells and cartilage cells, but he was unsure whether it would be successful a
'/>"/>

Contact: Richard Lewis
Richard_Lewis@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
2. EPAs new green parking lot allows scientists to study permeable surfaces that may help the environment
3. Fly eye paves the way for manufacturing biomimetic surfaces
4. Researchers design artificial cells that could power medical implants
5. TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants
6. Implants mimic infection to rally immune system against tumors
7. A step toward better brain implants using conducting polymer nanotubes
8. Smart coating opens door to safer hip, knee and dental implants
9. New material mimics bone to create better biomedical implants
10. Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers
11. Technique yields potential biological substitute for dental implants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanomodified surfaces seal leg implants against infection
(Date:12/19/2014)... LAS VEGAS , Dec. 18, 2014   ... platform built for the post-password and Internet of Things ... additional seed funding. The venture round was led by ... Pantera Capital, Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey ... the new funding to expand its team and bring ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in ... sensors in biomedical applications. Chemical sensors help in ... diagnosis during surgical procedures. The Global Chemical Sensor ...
(Date:12/11/2014)... Dec. 10, 2014  That blood pressure plays a role ... Hypertension – the medical term for high blood pressure – ... and the inflatable cuff that,s used in measuring blood pressure ... there,s nothing new about hypertension, its triggers and its effects. ... the condition and the best ways to treat it. ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... fruits and vegetables in ozone-enriched environments reduces spoilage explains ... Conference in Harrogate. Dr Ian Singleton explains how ozone ... as it leaves no residue on foods. It ... can be lost due to microbial spoilage. Dr Singleton ...
... The benefits of blueberry consumption have been demonstrated ... benefits derived from their high polyphenol content. Blueberries ... on everything from aging to metabolic syndrome. Recently, ... Denton, TX, examined whether blueberries could play a ...
... 2010 For years, scientists have thought of DNA as ... RNA transcription. Now, research led by scientists from the Florida ... also act to fine-tune the activity of certain proteins known ... it possible to design therapies that could activate specific genes ...
Cached Biology News:Ozone reduces fungal spoilage of fruits and vegetables 2Blueberries may inhibit development of fat cells 2Scripps Research scientists uncover new DNA role in modifying gene function 2Scripps Research scientists uncover new DNA role in modifying gene function 3
(Date:12/17/2014)... 17, 2014 Based on the ... surgical imaging market is dominated by four major ... imaging market. These players include GE Healthcare (U.K.), ... (Germany). , Full Report Copy at ... Healthcare can be attributed to its strong product ...
(Date:12/17/2014)... 2014 This report is a ... industry. For an overview analysis, the report introduces ... chain structure, industry overview, policy analysis, and news ... has witnessed rapid development with key manufacturers ... This report mentions quartz tubing upstream raw materials ...
(Date:12/17/2014)... 17, 2014  United Therapeutics Corporation (NASDAQ: ... well as changes to Martine Rothblatt , Ph.D,s ... United Therapeutics announced the promotion of ... Officer and David Zaccardelli , Pharm.D. to Executive ... these promotions, Dr. Rothblatt,s title will change from Chairman ...
(Date:12/15/2014)... & PETACH TIKVAH, Israel , ... BCLI ), a leading developer of adult ... wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. was awarded a ... Office of the Chief Scientist (OCS).  This ... receipt of grant support from the Office of the ...
Breaking Biology Technology:Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 42020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3
... Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), ... it has filed a shelf registration statement on Form ... when declared effective by the SEC, will allow Poniard ... to $60 million aggregate amount of its common stock, ...
... Fate Therapeutics, Inc. announced today ... owned by Children,s Hospital Boston and Massachusetts General Hospital. ... supporting hematopoietic stem cells. These proprietary technologies developed ... Program at Children,s Hospital Boston and a scientific founder ...
... CITY, Shandong, China, May 15 /PRNewswire-Asia-FirstCall/ -- China,Biologic ... or the,Company,), one of the leading plasma-based pharmaceutical ... announced that the Company,s,management will present at the ... in New York, NY on May 18, 2009 ...
Cached Biology Technology:Poniard Pharmaceuticals Files Shelf Registration 2Poniard Pharmaceuticals Files Shelf Registration 3Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital 2Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital 3China Biologic Products to Present at CCG IR's China Rising Conference and Oppenheimer's China Dragon Call Conference in New York 2China Biologic Products to Present at CCG IR's China Rising Conference and Oppenheimer's China Dragon Call Conference in New York 3China Biologic Products to Present at CCG IR's China Rising Conference and Oppenheimer's China Dragon Call Conference in New York 4
Bovine Serum Available Anticoagulants: N-02: Citrate N-04: Heparin (Na) N-06: K2EDTA N-08: Potassium Oxalate N-10: EDTA (Na) N-03: Alsevers N-05: ACD N-07: CPD N-09: K3EDTA N-11:...
DAPI: 4', 6-Diamino-2-phenylindole dihydrochloride. Antifade Solution: p-Phenylenediamine and glycerol in PBS solution. 0.4g/mL DAPI suspended in Antifade....
...
Takara's Mutan-Super Express Km Kit is designed to achieve site-directed mutagenesis in just one day. It is based on Oligonucleotide-directed Dual Amber (ODA) method, using the advantages of LA (Long...
Biology Products: