Navigation Links
Nanomedicine: Ending 'hit and miss' design
Date:12/10/2009

HOUSTON -- (Dec. 10, 2009) -- One of the promises of nanomedicine is the design of tiny particles that can home in on diseased cells and get inside them. Nanoparticles can carry drugs into cells and tag cells for MRI and other diagnostic tests; and they may eventually even enter a cell's nucleus to repair damaged genes. Unfortunately, designing them involves as much luck as engineering.

"Everything in nanomedicine right now is hit-and-miss as far as the biological fate of nanoparticles," said Rice University bioengineering researcher Jennifer West. "There's no systematic understanding of how to design a particle to accomplish a certain goal in terms of where it goes in a cell or if it even goes into a cell."

West's lab and 11 others in the Texas Medical Center -- including three at Rice's BioScience Research Collaborative -- are hoping to change that, thanks to a $3 million Grand Opportunity (GO) grant from the National Institutes of Health. NIH established the GO grant program with funding from the American Recovery and Reinvestment Act (ARRA).

One problem facing scientists today is that nanoparticles come in many shapes and sizes and can be made of very different materials. Some nanoparticles are spherical. Others are long and thin. Some are made of biodegradable plastic and others of gold, carbon or semiconducting metals. And sometimes size -- rather than shape or material -- is all-important.

West demonstrates this using a video on her computer that was created by Rice GO grant investigator Junghae Suh. The movie was created by snapping an image with a microscope every few seconds. In the video, dozens of particles move about inside a cell. Half of the particles are tagged with a red fluorescent dye and move very slowly. The rest are green and zip from place to place.

"These are made of the same material and have the same chemistry," said West, Rice's Isabel C. Cameron Professor and department chair of Bioenginee
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. National Institutes of Health Secures Armory with Patent-Pending Technology
2. New strategy for mending broken hearts?
3. Transport behavior of E. coli varies depending on manure source
4. VCU survey: US public supports genetic research, testing and government spending on research
5. MIT: Mending broken hearts with tissue engineering
6. Nitrous oxide emissions respond differently to no-till depending on the soil type
7. Extending the life of fresh cranberries
8. Coastal management cooperation, enforcement key to avoid pending crisis for millions: UN experts
9. Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts
10. New research suggests biofuel blending is often inaccurate
11. Stanford researchers say climate change will significantly increase impending bird extinctions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Social animals often develop relationships with other group members ... In wild chacma baboons the strategy for grooming activities ... are just published in the scientific journal Biology ... of baboons is not practiced without ulterior motives. To ... for the individual, while grooming another individual can provide ...
(Date:7/11/2014)... 11, 2014 The increased risk of kidney injury ... resuscitation fluids reflects the mass of HES molecules, according ... official journal of the International Anesthesia Research Society (IARS). ... harmful effect of HES on cultured human renal proximal ... Christian Wunder and colleagues of University Hospital Wrzburg, Austria. ...
(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... More than 20 percent of atheist scientists are spiritual, ... public marries spirituality and religion, the study found that spirituality ... with scientific discovery for "spiritual atheist" scientists. ... Sociology of Religion . Through in-depth interviews ...
... , A new study from Cambridge University has for ... a higher than average number of autistic traits. ... today in the Journal of Autism and Developmental ... of biological girls with gender incongruence that persists into ...
... Amsterdam, 5 May 2011 Elsevier, the ... products and services, announced today the launch ... The journal aims at reporting the most recent ... intelligent computation based on the principles of swarm ...
Cached Biology News:More than 20 percent of atheist scientists are spiritual 2Female-to-male transsexual people have more autistic traits 2Elsevier announces launch of Swarm and Evolutionary Computation 2
(Date:7/10/2014)... 10, 2014 Research and Markets ( ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid ... report to their offering. ... of photonic integration traces its roots in the ... of photonic integration went unexplored and unfulfilled for ...
(Date:7/10/2014)... to the International Atomic Energy Agency (IAEA) the ... acquiring sufficient quantities of plutonium or highly enriched ... device. The IAEA also notes that most cases ... which can be challenging to detect with most ... appearing this week in the Journal of ...
(Date:7/10/2014)... D.C., June 17, 2014 Using microscopic polymer ... specific gases, researchers at MIT,s Quantum Photonics Laboratory ... levels in the parts-per-billion range. Optical sensors are ... their high signal-to-noise ratio, compact, lightweight nature, and ... gas sensors had been developed before, the MIT ...
(Date:7/10/2014)... basis of psychiatric disorders has been extremely challenging because ... but are insufficient to cause disease. Now investigators reporting ... journal Cell Stem Cell describe a strategy ... interact with other risk factors or environmental exposures to ... pinpoints a genetic variant that may predispose individuals to ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2
... , ROCKAWAY, N.J., Dec. 14 ... Approach , published by the Infusion Nurses ... extravasation.(1) Anthracyclines are a group of chemotherapy medications including ... the treatment of various types of cancer since the early ...
... , WALTHAM, Mass., Dec. ... that it has signed a new, three-year master services ... and services that serve patients in approximately 100 countries. ... for translation of the company,s online content, which includes ...
... WALTHAM, Mass., Dec. 14 Decision Resources, one of the world,s ... that, owing to the launches of several new agents, the atrial ... in 2008 to $6.1 billion in 2018 in the United States, ... new Pharmacor report entitled Atrial Fibrillation finds that a ...
Cached Biology Technology:Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 2Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 3Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 4Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 5Multi-Billion Dollar Biotech Firm Chooses Lionbridge as Exclusive Translation Provider with Three-Year Master Services Agreement 2Multi-Billion Dollar Biotech Firm Chooses Lionbridge as Exclusive Translation Provider with Three-Year Master Services Agreement 3The Atrial Fibrillation Drug Market Will Increase More Than Sevenfold, from $790 Million in 2008 to $6.1 Billion in 2018 2
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selecitivty and potential CNS-Side Effect liabilities of compo...
... tested through 63 ligand ... spanning a broad therapeutic ... includes many non human ... non-selective assays. Used ...
... Receptor (PR) Competitor Assay Kits are ... progesterone receptor binding compounds using fluorescence ... a fusion of glutathione transferase to ... progesterone receptor [PR-LBD(GST)] and a proprietary, ...
... is critical to the maintenance of ... proteins as important and diverse as ... shock and stress response, antigen presentation, ... ion channels, cell cycle regulation, transcription, ...
Biology Products: