Navigation Links
'Nanoglassblowing' seen as boon to study of individual molecules
Date:6/12/2008

While the results may not rival the artistry of glassblowers in Europe and Latin America, researchers at the National Institute of Standards and Technology (NIST) and Cornell University have found beauty in a new fabrication technique called "nanoglassblowing" that creates nanoscale (billionth of a meter) fluidic devices used to isolate and study single molecules in solutionincluding individual DNA strands. The novel method is described in a paper posted online next week in the journal Nanotechnology.*

Traditionally, glass micro- and nanofluidic devices are fabricated by etching tiny channels into a glass wafer with the same lithographic procedures used to manufacture circuit patterns on semiconductor computer chips. The planar (flat-edged) rectangular canals are topped with a glass cover that is annealed (heated until it bonds permanently) into place. About a year ago, the authors of the Nanotechnology paper observed that in some cases, the heat of the annealing furnace caused air trapped in the channel to expand the glass cover into a curved shape, much like glassblowers use heated air to add roundness to their work. The researchers looked for ways to exploit this phenomenon and learned that they could easily control the amount of "blowing out" that occurred over several orders of magnitude.

As a result, the researchers were able to create devices with "funnels" many micrometers wide and about a micrometer deep that tapered down to nanochannels with depths as shallow as 7 nanometersapproximately 1,000 times smaller in diameter than a red blood cell. The nanoglassblown chambers soon showed distinct advantages over their planar predecessors.

"In the past, for example, it was difficult to get single strands of DNA into a nanofluidic device for study because DNA in solution balls up and tends to bounce off the sharp edges of planar channels with depths smaller than the ball," says Cornell's Elizabeth Strychalski. "The gradu
'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Woolly-mammoth gene study changes extinction theory
2. From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals
3. Study of guanacos launched in Chile
4. New study reveals large scale conservation essential
5. Study finds Chinese food good for your heart
6. Study identifies brain pathway that shuts down seizures
7. NOAA study shows eastern tropical pacific ocean dolphin populations improving
8. RAND study finds increase in piracy and terrorism at sea
9. Moores UCSD Cancer Center study links vitamin D, type 1 diabetes
10. UNH receives $380,000 grant to study organic dairy as closed ecosystem
11. Study finds healthy intestinal bacteria within chicken eggs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Nanoglassblowing' seen as boon to study of individual molecules
(Date:4/17/2014)... and pathogens that devastate honeybees in Europe, Asia and ... do not appear to be impacting native honeybee populations ... researchers., The invasive pests include including Nosema microsporidia ... honeybees appear to be resilient to these invasive pests, ... control pests in Europe, Asia and the United States ...
(Date:4/17/2014)... many serious conditions such as heart disease, epilepsy and ... therapies. Unfortunately, there is still much scientists do not ... and unexpected insight into the structure of sodium channels ... - which are responsible for ,fine-tuning, the activity of ... recent edition of the Journal of Biological Chemistry ...
(Date:4/17/2014)... researchers have detected new early-warning signs of the potential ... have far-reaching implications for the diagnosis and treatment of ... million Americans. , "We had not expected to see ... stages," said Ann Elsner, professor and associate dean in ... the study. "We set out to study the early ...
Breaking Biology News(10 mins):East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Structure of sodium channels different than previously believed 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... international consortium of 15 institutions from 12 European ... Norway, Romania, Sweden, The Netherlands, UK) has started ... The name stands for ,Biodiversity and Ecosystem Services: ... the effectiveness of arguments used for biodiversity protection ...
... the Arctic Ocean, the frozen soils within this region keep ... the Earth,s atmosphere. This sequestered carbon is more than 250 ... United States in the year 2009. As global temperatures slowly ... upon the carbon cycle when the permafrost thaws and releases ...
... metal-organic frameworks, with their nanoscopic pores and incredibly ... gas storage. But with millions of different structures ... University research team has developed a computational method ... in the discovery process. The new algorithm automatically ...
Cached Biology News:Preparing for a thaw: How Arctic microbes respond to a warming world 2Preparing for a thaw: How Arctic microbes respond to a warming world 3More promising natural gas storage? 2
(Date:1/14/2014)... owners drew up their lists of New Year,s resolutions for 2014, ... my furry companion." Nowadays there are pet salons, dog and cat ... the little canine or feline darlings along wherever mommy or daddy ... toys at the pet store. But anyone who has ever lived ...
(Date:1/14/2014)... MA (PRWEB) January 14, 2014 iLab Solutions, ... Detwiler as the new Director of Product Strategy. In this ... well as iLab sub-teams to guide in the development of ... iLab provides the maximum possible benefit to the scientific community ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
(Date:1/14/2014)... Independent publisher Bitingduck Press, with offices in Altadena ... ideas for 2014 in production and sales of interactive ... high-quality, low-cost, DRM-free ebooks and to use the sales ... first major development will be bookstore sales in local ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... 18 Opsona Therapeutics, a,biotechnology company focused on ... diseases, today announced the,completion of an EUR18M ($23M) ... expand both at an operational and clinical level. ... and Seroba Kernel,Life Sciences all participated in the ...
... Forschungsgemeinschaft (DFG, German Research Foundation) has announced that ... high-risk research projects. The Joint Committee of Germany,s ... approved funding for two new Reinhart Koselleck Projects. ... Professor Reinhard Drner, an atomic physicist from Frankfurt, ...
... found that tiny nanoparticles could be twice as likely ... liquids than previously believed. This opens up a ... in living cells, polymer composites, and high-tech foams, ... ways of further artificially enhancing this new found sticking ...
Cached Biology Technology:Opsona Therapeutics Closes EUR18M Funding 2Opsona Therapeutics Closes EUR18M Funding 3Opsona Therapeutics Closes EUR18M Funding 4Encouraging high-risk research: DFG approves funding for 2 new Reinhart Koselleck projects 2Encouraging high-risk research: DFG approves funding for 2 new Reinhart Koselleck projects 3Nanoparticles double their chances of getting into sticky situations 2
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... Rabbit monoclonal [EP282Y] to Asparagine ... all tested applications). ... corresponding to residues in the ... Entrez GeneID: ...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: