Navigation Links
Nanoemulsion potent against superbugs that kill cystic fibrosis patients
Date:2/4/2009

ANN ARBOR, Mich. University of Michigan scientists report highly encouraging evidence that a super-fine oil-and-water emulsion, already shown to kill many other microbes, may be able to quell the ravaging, often drug-resistant infections that cause nearly all cystic fibrosis deaths.

Cystic fibrosis is an inherited chronic lung disease that affects 30,000 children and adults in the United States. Patients have mucus-clogged lungs that leave them vulnerable to repeated, ever more serious respiratory infections.

"A key finding in the study is that we have a product that shows very good activity against a variety of bacteria that are very resistant to all known antibiotics. These really are superbugs," says John J. LiPuma, M.D., first and corresponding author of the study in the journal Antimicrobial Agents and Chemotherapy.

The research is a collaboration between LiPuma, professor of pediatrics at the U-M Medical School, and James R. Baker Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences at U-M and the study's senior author. Nanoemulsions developed at Baker's institute consist of soybean oil, water, alcohol and surfactants forced by high-stress mechanical extrusion into droplets less than 400 nanometers in size.

These emulsions have already proved to be non-toxic, potent killers of bacteria such as Streptococcus pneumoniae, H. influenzae and gonorrhea, of viruses such as herpes simplex and influenza A, and of several fungi. Nanoemulsion treatments for cold sores and toenail fungus are in Phase 3 clinical trials.

"We have a product that looks like it could be safely administered to the lungs of people with cystic fibrosis," LiPuma says. If future trials show that patients can tolerate effective doses of the nanoemulsion, he adds, "This could be a major breakthrough in the treatment of cystic fibrosis."

The novel physical mode of action -- the nan
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
2. Neuronal conduction of excitation without action potentials based on ceramide production
3. To maximize biofuel potential, researchers look for sorghums sweet spot
4. Joslin researchers uncover potential role of leptin in diabetes
5. Chemistry turns killer gas into potential cure
6. Researchers examine worlds potential to produce biodiesel
7. New inhibitor has potential as cancer drug
8. Potential new therapeutic molecular target to fight cancer
9. WCS study finds potential to double tiger numbers in South Asia
10. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
11. Great potential to improve collection, recycling of Europes electronic waste, says UN report
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoemulsion potent against superbugs that kill cystic fibrosis patients
(Date:5/21/2013)... "place" is increasingly being considered in the management ... new resource that can help them recognize and ... places in their lives. , Place-Based Conservation: ... co-edited by the Pacific Northwest Research Station,s Linda ... to conservation. The book is published by Springer ...
(Date:5/21/2013)... found that a class of pharmaceuticals can both prevent ... drugs, known as "TSPO ligands," are currently used for ... effects of TSPO ligand in young adult mice when ... mice when pathology was quite severe," said lead researcher ... "TSPO ligand reduced measures of pathology and improved behavior ...
(Date:5/21/2013)... of Michigan Water Center today awarded 12 research ... restoration and protection efforts. , The two-year grants ... including efforts to track the remediation of harmful ... control non-native weedy plant invasions; study chromosomal damage ... to restoration activities. , The grants were awarded ...
Breaking Biology News(10 mins):Drugs found to both prevent and treat Alzheimer's disease in mice 2U-M Water Center awards $570K in Great Lakes restoration grants 2U-M Water Center awards $570K in Great Lakes restoration grants 3U-M Water Center awards $570K in Great Lakes restoration grants 4
... dawn of the biological sciences, mankind has struggled to ... animals the arthropods. Now, a team of researchers, ... the Natural History Museum of Los Angeles County (NHM), ... relationships among the arthropods, answering many questions that defied ...
... engineer at the University of WisconsinMilwaukee (UWM) can not ... cell will produce, but also foresee the outcome before ... by Andrew Cohen, an assistant professor of electrical engineering, ... will allow scientists to search for mechanisms that control ...
... Benjamin Franklin,s advice that "an ounce of prevention ... applied to today,s most pressing health issue: obesity. Because ... preventing the progression of weight gain throughout life, especially ... area of great interest is the possibility that being ...
Cached Biology News:Where did insects come from? 2Where did insects come from? 3UWM researcher predicts stem cell fate with software 2UWM researcher predicts stem cell fate with software 3Later introduction of baby foods related to lower risk of obesity later in life 2
(Date:5/22/2013)... Alton Housing Authority was hit by bed bugs. A ... their presence has already caused the company $35,000 for treatment. ... spending, My Cleaning Products shared a way how to ... the report that to clear the infestation , the ... employees also attended a mandatory training on bed bugs, it ...
(Date:5/22/2013)... -- Moderna Therapeutics, the pioneering company developing messenger RNA therapeutics™, ... in vivo production of therapeutic proteins, announced today ... Moderna in early July as its first Chief Information ... in the design and implementation of information systems underlying ... clinical operations and commercial preparedness. John has also been ...
(Date:5/21/2013)... May 21, 2013 Custom Learning ... reporting eLearning solution using Tin Can API combined ... tool. CLD is a leading developer of training ... device companies worldwide. , Tin Can API ... helps learners and trainers more accurately measure the ...
(Date:5/21/2013)... May 21, 2013 The congress ... Transplant Association) is the biggest congress in ... Nearly 10,000 participants are in Istanbul ... research findings. New pioneering studies have been presented: ... PYROPHOSPHATE (SFP) ADMINISTERED VIA HEMODIALYSATE REDUCES ESA USE" ...
Breaking Biology Technology:Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 3ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3
... Stratagenes GeneConnection cDNA gene clusters are novel and more ... , Jason Goncalves Jean-Michel Lelias Joe Sorge ... YY ,goes beyond normal cDNA collections. Stratagene ... identified thousands of cDNAs that are not found ,in ...
... One column purification of protein with native amino ... Wyborski * John C. Bauer * Barbara McGowan ... Systems, Inc. , Stratagene has improved the Affinity ... the pCAL-n-EK vector. This E. coli,cloning and expression ...
... system provides quality images from,nanogram quantities of RNA , ... ,Stratagene , The SYBR Gold ... II still,video system, allows the integrity of only ... , In Stratagenes Custom Library Department, we often construct cDNA,libraries ...
Cached Biology Technology:The GeneZoo or the GeneJungle? 2The GeneZoo or the GeneJungle? 3The GeneZoo or the GeneJungle? 4The GeneZoo or the GeneJungle? 5The GeneZoo or the GeneJungle? 6The GeneZoo or the GeneJungle? 7The GeneZoo or the GeneJungle? 8The GeneZoo or the GeneJungle? 9The GeneZoo or the GeneJungle? 10Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 2Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 3Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 4Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 5Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 6Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 7Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 8Improved Sensitivity for Staining RNA with SYBR Gold Stain 2Improved Sensitivity for Staining RNA with SYBR Gold Stain 3
Mouse Serpin F1/PEDF MAb (Clone 199315)...
Mouse Nodal Affinity Purified Polyclonal Ab...
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, Serine Protease Regulators...
Biology Products: