Navigation Links
Nanodisk gene therapy
Date:1/11/2011

One of the challenges of gene therapy - a set of methodologies aimed at treating several nucleic acid diseases (DNA or RNA) - is to assure that this material arrives directly to the nucleus of the cell without losing a substantial amount along the way and without producing any undesired side effects. With this aim, scientists experiment with the use of different types of vectors, molecules capable of transporting genetic material to the correct place. Presently, natural "deactivated" viruses are the most commonly used vectors in clinical trials, their side effects however often limit therapeutic application.

One of the most promising alternatives in this field is the use of artificial viruses. These viruses can be constructed through genetic engineering by assembling minute protein structures made up of peptides, the building blocks of proteins.

The team of scientists, led by Antonio Villaverde, lecturer of the Department of Genetics and Microbiology, researcher at the UAB Institute of Biotechnology and Biomedicine and of the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), demonstrated that the peptide R9, formed by a specific type of amino-acid (arginine), can encapsulate genetic material, assemble itself with other identical molecules to form nanoparticles and enter directly into the cell nucleus to release the material it contains. The nanoparticles have the shape of a disk, with a diameter measuring 20 nanometres and a height of 3 nm.

The study was published recently in the journals Biomaterials and Nanomedicine and describes how scientists studied the performance of R9 nanodisks in the interior of the cells using confocal microscopy techniques provided by the UAB Microscopy Service and applied by Dr Mnica Roldn. The images show that once the cell membrane is passed, particles travel directly to the nucleus at a rate of 0.0044 micrometres per second, ten times faster t
'/>"/>

Contact: Antonio Villaverde
antoni.villaverde@uab.cat
34-935-813-086
Universitat Autonoma de Barcelona
Source:Eurekalert

Page: 1 2

Related biology news :

1. Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy
2. New breathing therapy reduces panic and anxiety by reversing hyperventilation
3. Missing molecules hold promise of therapy for pancreatic cancer
4. Cell of origin for brain tumors may predict response to therapy
5. Killing drug-resistant melanoma requires combination therapy
6. Higher co-payments increase chance of early discontinuation, inadequate use of breast cancer therapy
7. SEBM European Best Poster Prize awarded at Annual Conference of the German Society for Gene Therapy
8. Combination therapy reduced HER2-positive breast cancers
9. Phase III study compared neoadjuvant therapy with lapatinib or trastuzumab for early breast cancer
10. Early safety results promising for Phase I/II trial of gene therapy treatment of hemophilia B
11. Virginia Tech engineers introduce thermotherapy as a chemotherapy alternative
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... uncanny precision are key parts of high-powered lenses, ... instead of electricity. But producing these crystals by ... precise beam of electrons, is often extremely difficult ... Columbia universities have proposed a new method that ... specialized materials, known as photonic crystals, with relative ...
(Date:7/22/2014)... kids will hear that drinking milk helps make their bones strong ... messages foster the idea that if something is good for us, ... the Journal of Consumer Research , when children hear about ... , "We predicted that when food is presented to children as ... such as learning how to read or count, they would conclude ...
(Date:7/22/2014)... that feature natural habitats and trees and not just ... according to a University of Colorado Boulder study. , ... also provide stress-reducing benefits for youth, according to a ... The study is one of the first of ... access to green settings and stress. , "Many schools ...
Breaking Biology News(10 mins):Technique simplifies the creation of high-tech crystals 2Technique simplifies the creation of high-tech crystals 3Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3
... to newly placed sod may result in nutrient runoff into ... to apply fertilizer and what kind is the best for ... team of scientists from Texas A&M AgriLife Research: Dr. Jacqui ... Ben Wherley, assistant professor of turfgrass science and ecology; Dr. ...
... reverse a principal cause of global warming? A new study ... population that keeps sea urchins in check will in turn allow kelp ... times the amount of CO 2 from the atmosphere than if ... The theory is outlined in a paper released online today (September ...
... North Carolina State University shows that exposure to the chemical ... of anxiety by causing significant gene expression changes in a ... also found that a soy-rich diet can mitigate these effects. ... variety of species, and wanted to begin to understand why ...
Cached Biology News:Turf study to monitor runoff, establish fertilizer management practices 2UC Santa Cruz study shows how sea otters can reduce CO2 in the atmosphere 2Study finds how BPA affects gene expression, anxiety; Soy mitigates effects 2
(Date:7/22/2014)... 22, 2014 The Board of Directors of BD ... declared a quarterly dividend of 54.5 cents per common share ... September 9, 2014. The indicated annual dividend rate is $2.18 ... is a leading medical technology company that partners with customers ... and evolving health needs. Our innovative solutions are focused on ...
(Date:7/22/2014)... within a phylum so full of mean little creatures, the ... its cruelty -- at least to crickets. Native to the ... most predatory sort of parasite. It swoops onto the back ... and leaves its wicked brood to invade, kill and consume ... would be possible without the fly,s ability to find a ...
(Date:7/22/2014)... Institute of Standards and Technology (NIST) and California ... design for an atomic clock that is based ... , The microcomb clock, featured on the cover ... Optica ,* is the first demonstration of ... conversion of optical frequencies to lower microwave frequencies. ...
(Date:7/22/2014)... in water with ultrasound and they,ll spin around their ... yet knows exactly. But researchers at the National Institute ... it,s fast. At up to 150,000 revolutions per minute, ... object submerged in liquid ever reported. , The discovery ... that they could be used not only for moving ...
Breaking Biology Technology:Fly-inspired sound detector 2Fly-inspired sound detector 3Fly-inspired sound detector 4'Comb on a chip' powers new NIST/Caltech atomic clock design 2NIST shows ultrasonically propelled nanorods spin dizzyingly fast 2
... 2 SAFC Hitech(TM), a focus,area within SAFC(R), ... SIAL ),today announced the introduction of the OM700, ... to controlled precursor delivery,for larger lot sizes, enabling ... controls., The OM700 offers reliable and very ...
... geographic scales ranging from vast climatic regions of the Earth ... of soil nano-particles in a pinch of soil. , ... properties vary from the summit of a hill down to ... less than a quarter inch in diameter, there is a ...
... major U.S. cancer conference, CHICAGO, May 30 ... evolving field of molecular diagnostics, announced today that ... prognosis test,will be presented at the American Society ... show that MammaPrint, a,prognostic test for breast cancer ...
Cached Biology Technology:SAFC Hitech Introduces Large Scale Bubbler for Compound Semiconductor Production 2SAFC Hitech Introduces Large Scale Bubbler for Compound Semiconductor Production 3Sophisticated soil analysis for improved land use 2MammaPrint(R) Breast Cancer Test Provides Valuable Insight for Personalized Treatment Decisions 2MammaPrint(R) Breast Cancer Test Provides Valuable Insight for Personalized Treatment Decisions 3MammaPrint(R) Breast Cancer Test Provides Valuable Insight for Personalized Treatment Decisions 4
Denhardt's Solution is a mixture of blocking agents used in membrane-based hybridization protocols. The solution contains 1% Ficoll (type 400) 1% polyvinylpyrrolidone and 1% bovine serum albumin. Ste...
... 97 Cytological Labeling Kit provides a unique ... of cellular targets, including cell-surface receptors and ... Kit contains the patented ELF 97 phosphatase ... precipitate at the site of enzymatic activity ...
... H 10 O 2 S 2 ... Form: White crystalline powder Assay: greater ... By IR Melting Point: greater than ... less than or equal to 1% ...
... consists of an anodized aluminum body in ... Compounds embedded in polymerized matrix. It is ... and Synergy Multi-Detection Readers. This multi-functional test ... reducing the need for tedious wet testing. ...
Biology Products: