Navigation Links
Nanodiamonds deliver insulin for wound healing
Date:7/27/2009

Ho says this ability to release therapeutics from the nanodiamonds on demand represents an exciting strategy towards enhancing the specificity of wound treatment.

In their studies, Ho and his colleagues showed that the insulin was very tightly bound to the nanodiamonds when in an aqueous solution near the normal physiological pH level. Measurements of insulin function revealed that the protein was virtually inactive when bound to the nanodiamonds -- a beneficial property for preventing excess or unnecessary drug release.

Upon increasing the pH to the basic levels commonly observed in the skin during severe burns, the researchers confirmed the insulin was released from the nanodiamond clusters and retained its function. Exploiting this pH-mediated release mechanism may provide unique advantages for enhanced drug delivery methods.

The researchers also found the insulin slowly and consistently released from the nanodiamond clusters over a period of several days.

Insulin accelerates wound healing by acting as a growth hormone. It encourages skin cells to proliferate and divide, restores blood flow to the wound, suppresses inflammation and fights infection. Earlier investigations have confirmed an increase in alkalinity of wound tissue, due to bacterial colonization, to levels as high as pH 10.5, the pH level that promoted insulin release from the nanodiamonds in the Northwestern study.

Ho's group next will work on integrating the nanodiamond-insulin complexes into a gel and conducting preclinical studies. The researchers also will investigate different areas of medicine in which the nanodiamond-insulin clusters could be used.

Nanodiamonds have many advantages for biomedical applications. The large surface area allows a large amount of therapeutic to be loaded onto the particles. They can be functionalized with nearly any type of therapeutic, including small molecules, proteins and antibodies. They can be suspended ea
'/>"/>

Contact: Kyle Delaney
k-delaney@northwestern.edu
847-467-4010
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New tool for next-generation cancer treatments using nanodiamonds
2. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
3. Preventing ear infections in the future: Delivering vaccine through the skin
4. Bulls-eye electrode helps interpret thoughts, deliver stimulus to aid paralyzed, epileptic patients
5. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
6. Nanotechnology holds promise for STD drug delivery
7. MIT: Jeremy Nathans to deliver Scolnick Prize lecture
8. New type of vaccines deliver stronger and faster immune response
9. Depression during pregnancy can double risk of preterm delivery
10. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
11. RNA molecules, delivery system improve vaccine responses, effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... 21, 2015 Passwords have proven futile ... the recent U.S. Office of Personnel Management breach. ... infosec conundrum, but developers and end-users are concerned ... this dilemma, Biometrics-as-a-Service provider HYPR Corp. announced today ... for third party integration. A ...
(Date:7/9/2015)...  Synaptics Inc. (NASDAQ: SYNA ), a leading developer ... report financial results for the fourth quarter and fiscal ... close of market. The company will host a corresponding ... PT (5:00 p.m. ET), during which management may discuss ... live call, analysts and investors should dial 888-455-2260 (conference ...
(Date:7/8/2015)... 8, 2015 Summary Pancreatic cancer is ... most fatal, with a mortality rate of 10.9 deaths ... pancreatic cancer patients has highlighted a significant need for ... being met by the current market. A highly ... with varying molecule types and mechanisms of action, which ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3
... period of torpor to conserve energy when resources are scarce. ... champion by far among vertebrates is the burrowing frog ( ... in the mud in the absence of any food or ... scientists at the University of Queensland have discovered that the ...
... new arsenal for meningitis treatment and the war on ... developed by scientists at the Institute of Bioengineering and ... Nanotechnology . The stable bioengineered nanoparticles devised at ... cells that could cause fatal infections and are highly ...
... new song from a member of its own species, the experience ... The sequential switching on and off of thousands of genes after ... memory in the songbird brain. The finding, detailed this month ... was a surprise, said principal investigator David Clayton, a professor of ...
Cached Biology News:Super-sleepers could help super-sizers! 2Singapore nanotechnology combats fatal brain infections 2Researchers see evidence of memory in the songbird brain 2
(Date:8/3/2015)... DIEGO , Aug. 3, 2015  Halozyme Therapeutics, ... Update Conference Call for the second quarter 2015 on ... PT. Dr. Helen Torley , president and chief ... date post-market, Halozyme will release financial results for the ... webcast live through the "Investors" section of Halozyme,s corporate ...
(Date:8/3/2015)... 3, 2015  Merck KGaA, Darmstadt, Germany ... high-tech products in the healthcare, life science and performance ... Nano-C, their development and launch of promising new fullerene ... Merck KGaA, Darmstadt, Germany , is ... sector. Novel derivatives: highly stable, easy to ...
(Date:8/3/2015)... NEW YORK , August 3, 2015 ... "Global Market Study on 3D Cell Culture: ... published by Persistence Market Research, the global 3D cell culture ... is expected to expand at a CAGR of 29.1% ... View Full Report with TOC:  http://www.persistencemarketresearch.com/market-research/3d-cell-cultures-market.asp ...
(Date:7/31/2015)... China Cord Blood Corporation (NYSE: CO) ("CCBC" ... provider of cord blood collection, laboratory testing, hematopoietic stem ... that the Company has filed its Annual Report on ... The filed Form 20-F includes audited financial statements for ... 20-F can be accessed by visiting the U.S. Securities ...
Breaking Biology Technology:Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4China Cord Blood Corporation Files Its Annual Report on Form 20-F 2
... Prevalence and Roles of miRNAs , ... cloned , and sequenced from human ... apparently regulates multiple genes, and miRNAs are thought to , ... predict mRNA target sites for miRNAs [2,3]. A handful of these , ...
... Construction Kit , Prepare your probe in ... Ideal for siRNA/miRNA studies , ... high specific , activity RNA probes for RPA, Northern, Southern, ... No cloning required , ...
... , with a fluorometer capable of ... ultra-sensitive assay for determining RNase A specific activity. The , ... including RNase A, T1, RNase I, micrococcal ... nuclease, and Benzonase. In addition to detecting , ...
Cached Biology Technology:Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 2Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 3Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 4Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 5Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 6Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 7Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 8Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 9Prepare siRNA and miRNA Probes in Just 1 Hour 2Prepare siRNA and miRNA Probes in Just 1 Hour 3Measuring RNase Activity A Real-time Kinetic Analysis 2Measuring RNase Activity A Real-time Kinetic Analysis 3Measuring RNase Activity A Real-time Kinetic Analysis 4Measuring RNase Activity A Real-time Kinetic Analysis 5
... combines 2 products into 1:, , A ... isolation kit , ,The FastPrep System ... Qbiogene/BIO101 System Matrix and Isolation Kits. Samples ... tubes eliminating the use of metal probes ...
Abgene's ALTO-8 is the first automated decapper/capper for Abgene Twist-Lock tubes....
Sterile, individually wrapped, 4mm Cuvettes...
... III RNase H- Reverse ... improved version of SuperScript™ ... Like SuperScript™ II it ... strand from single-stranded RNA ...
Biology Products: