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Nanodiamond drug device could transform cancer treatment
Date:10/2/2008

cation of nanodiamonds for systemic drug-carrying applications. This new work successfully transitions the nanodiamonds from basic materials to serving as a foundation for device manufacturing.

To build the biomedical device, the researchers developed a streamlined approach where a double layer of parylene was fabricated, with the nanodiamond-drug complexes sandwiched in between. The bottom layer, approximately 20 to 30 microns thick, serves as the backbone of the device, allowing it to be easily handled. For the top layer, the research team created a thinner semi-porous film that allows the drug to slowly release from the device.

"One of the most significant aspects of this work is that the fabrication procedures are highly scalable, meaning hundreds, or even thousands, of devices potentially could be manufactured in parallel and at low cost," said Ho.

"The nanodiamonds are quite economical and have already been mass-produced as lubrication components for automobiles and for use in electronics," added Robert Lam, a graduate student in Ho's research group and the article's lead author.

In the area of localized chemotherapy, the team hopes that this technology will bring new levels of treatment efficacy that can complement injected chemotherapy to reduce dosages and decrease devastating side effects.

Because of the proven biocompatibility and massively parallel deposition capabilities of parylene, the researchers are engaged with pre-clinical trials of the nanodiamond-embedded parylene.


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Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

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