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'Nanobubbles' plus chemotherapy equals single-cell cancer targeting
Date:4/9/2012

bbles, the researchers must first get the gold nanoclusters inside the cancer cells. The scientists do this by tagging individual gold nanoparticles with an antibody that binds to the surface of the cancer cell. Cells ingest the gold nanoparticles and sequester them together in tiny pockets just below their surfaces.

While a few gold nanoparticles are taken up by healthy cells, the cancer cells take up far more, and the selectivity of the procedure owes to the fact that the minimum threshold of laser energy needed to form a nanobubble in a cancer cell is too low to form a nanobubble in a healthy cell.

The research is funded by the National Institutes of Health and is described in the following recent papers:

  • "Cell-specific transmembrane injection of molecular cargo with gold nanoparticle-generated transient plasmonic nanobubbles," which is due for publication later this month in Biomaterials. Co-authors include Lapotko, Ekaterina Lukianova-Hleb and Daniel Wagner, all of Rice, and BCM's Brenner.
  • "Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells," which appeared in the February issue of Biomaterials. Co-authors include Lapotko, Lukianova-Hleb, Andrey Belyanin and Shruti Kashinath, all of Rice, and MD Anderson's Wu.
  • "Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells," which was published online March 7 in the journal Advanced Materials. Co-authors include Lapotko and Lukianova-Hleb, both of Rice; Wu and Ren, both of MD Anderson; and Joseph Zasadzinski of the University of Minnesota.
  • "Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems," which was published online April 3 in PLoS ONE. Co-authors include Laptoko, Wagner, Lukianova-Hleb, Daniel Carson, Cindy Farach-Carson, Pamela Co
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Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

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