Navigation Links
Nano vaccine for hepatitis B shows promise for third world
Date:8/12/2008

sion vaccine proved effective at producing three types of immunity: systemic, mucosal and cellular. Further toxicity studies in rodents and dogs showed the vaccine was safe and well-tolerated.

The vaccine was as effective as current hepatitis B vaccines in eliciting systemic protective antibodies in the blood of animals. The nanoemulsion acted as an effective adjuvant, without the need for a traditional adjuvant or inflammatory compound as in the current hepatitis B vaccines.

In addition, the nanoemulsion vaccine produced sustained cellular immunity in Th1 cells, which could make the vaccine useful in treating people with chronic hepatitis B whose own cellular immune responses are inadequate.

The animals given the nasal nanoemulsion in the study also activated a third type of immunity, mucosal immunity, which is gaining recognition among immunologists as a key first-line response to infectious agents in diseases such as hepatitis B where mucosal tissues are involved in transmission. Baker and his team found the same effect of activating mucosal immunity that was seen in their previous studies of other nanoemulsion-based vaccines.

The researchers tested whether the vaccine could remain stable and effective even if not refrigerated. They found the nanoemulsion vaccine retained its effectiveness for six months when kept at 25 degrees Celsius (77 degrees Fahrenheit), and even was stable and effective for six weeks at 40 degrees C (104 degrees F). This suggests that refrigeration will not be needed for the final distribution of the vaccine in developing countries, making it easier to vaccinate underserved people.

Current studies are focused on developing the preclinical data required to enter human trials, Baker says. The researchers hope that the first human trial can begin within a year.


'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCF professor develops vaccine to protect against black plague bioterror attack
2. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
3. Prostate cancer vaccines more effective with hormone therapy
4. From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
5. Footrot vaccine closer than ever
6. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
7. VaxInnate to discuss seasonal and pandemic flu vaccines during BIO 2008 this week
8. A protein sequence associated with Huntington’s disease may become life-saving vaccine component
9. New technology for boosting vaccine efficiency
10. New vaccine may give long-term defense against deadly bird flu and its variant forms
11. Vaccine for Ebola virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... from The Chinese University of Hong Kong, BGI and ... linked to salt tolerance, with implication for improving this ... published online in Nature Communications provides an ... improvement. , Soybean is an important crop for the ... have less genetic diversities than their wild counterparts. Among ...
(Date:7/11/2014)... develop relationships with other group members to reduce aggression ... baboons the strategy for grooming activities shows a certain ... in the scientific journal Biology Letters . , ... not practiced without ulterior motives. To be groomed has ... while grooming another individual can provide access to infants, ...
(Date:7/11/2014)... explored two different ways that allow unprecedented experimental ... formation of oxygen molecules in photosynthesis. The two ... Nature Communications . , "The new knowledge ... water oxidation, which are key components for building ... solar energy in fuels like hydrogen, ethanol or ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... a person,s body mass consisting of skeletal muscle, chronic ... in the limbs can result in significant physical ... community health professor Kimberly Huey, past research has demonstrated ... associated with reduced expression of certain pro-inflammatory cytokines, in ...
... tool to monitor deforestation and degradation in tropical ... Gordon and Betty Moore Foundation has awarded the ... $1.6-million grant to expand and improve CLASLite (The ... method that enables even the smallest governments and ...
... site today, it,s easy to forget that a dam and ... Franbrook Farm Research Station in southwestern Wisconsin. All traces of ... and weedy, now carpet the floor of the former basin. ... into the soils of the basin, UW-Madison researchers are now ...
Cached Biology News:Vitamin E shows possible promise in easing chronic inflammation 2Vitamin E shows possible promise in easing chronic inflammation 3Tropical forest carbon monitoring gets big boost 2Researchers examine role of soil patterns in dam restoration 2Researchers examine role of soil patterns in dam restoration 3
(Date:7/11/2014)... 11, 2014  Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
(Date:7/10/2014)... London, UK (PRWEB) July 10, 2014 ... inaugural 21st Century Medicine Forum on ‘Commercialising Longevity ... scientists and entrepreneurs to the London Bioscience Innovation ... Biogerontology Research Foundation and Aging Analytics Ltd. The ... and investment in translational research for age-related disease, ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of ... to announce the relaunch of his highly informative blog, now ... called “ What are Stem Cells ?” Dr. Harman’s ... foundation in the basics of stem cell therapy so that ... type of treatment when considering regenerative medicine. , A veterinarian ...
(Date:7/10/2014)... , July 10, 2014  Franciscan St. ... of capnography for respiratory monitoring outside the ... healthcare leaders in embracing state-of-the-art patient safety ... patients are breathing and can alert medical ... measuring the amount of carbon dioxide the ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... England and LANGHORNE, Pennsylvania, September 1, 2010, ... ... ... are keyed by longUrl, so we need to grab the first one. for (var r in data.results) ...
... Inc. (Nasdaq: BIOD ) announced today that ... trade name for Biodel,s  most advanced product candidate.  The ... an alternative name for Biodel,s more-rapid-acting insulin formulation that ... Drug Administration with a Prescription Drug User Fee Application ...
... high-tech broth full of silver nanowires and carbon nanotubes, Stanford ... easily be implemented to purify water in the developing world. ... filters do, the new filter lets them flow on through ... passed through, they have also passed on, because the device ...
Cached Biology Technology:EUSA Pharma Announces the Appointment of Stephen A. Stamp to its Board of Directors 2EUSA Pharma Announces the Appointment of Stephen A. Stamp to its Board of Directors 3EUSA Pharma Announces the Appointment of Stephen A. Stamp to its Board of Directors 4EUSA Pharma Announces the Appointment of Stephen A. Stamp to its Board of Directors 5EUSA Pharma Announces the Appointment of Stephen A. Stamp to its Board of Directors 6EUSA Pharma Announces the Appointment of Stephen A. Stamp to its Board of Directors 7High-speed filter uses electrified nanostructures to purify water at low cost 2High-speed filter uses electrified nanostructures to purify water at low cost 3High-speed filter uses electrified nanostructures to purify water at low cost 4
... calibration, and validation (MCV) plate ... plate used for hands-free startup, ... using the Bio-Plex suspension array ... for use with Bio-Plex Manager ...
... first biological reagent that eliminates ... not just by inhibiting growth. ... agent that can be used ... The cytotoxicity of Mynox is ...
A component of the Acridinium protein labeling kit....
... NHS ester can be used ... acids. The covalently bound acridinium ... in the presence of hydrogen ... can be used as a ...
Biology Products: