Navigation Links
Nano detector for deadly anthrax

An automatic and portable detector that takes just fifteen minutes to analyze a sample suspected of contamination with anthrax is being developed by US researchers. The technology amplifies any anthrax DNA present in the sample and can reveal the presence of just 40 microscopic cells of the deadly bacteria Bacillus anthracis.

B. anthracis, commonly known as anthrax, is a potentially lethal microbe that might be used intentionally to infect victims through contamination of food and water supplies, aerosolized particles, or even dried powders, such as those used in bioterrorist attacks in the USA. Detection is crucial to preventing widespread fatalities in the event of an anthrax attack. However, the complexity of the microbe's biology have so far made it difficult to build a portable system that can be employed quickly in the field. That said, there are several systems available that use PCR to amplify a particular component of the genetic material present in anthrax and then to flag this amplified signal. These systems are fast and sensitive but do not integrate sample preparation and so are not as convenient as a single detector unit would be.

Writing in the International Journal of Biomedical Nanoscience and Nanotechnology this month, Nathaniel Cady of the College of Nanoscale Science and Engineering (CNSE) of the University at Albany and colleagues there and at Cornell University, New York, explain how they have constructed nanofabricated fluidic cartridges that can be used to carry out detection of anthrax. The device is a so-called "lab-on-a-chips" device, or more properly a 3D microfluidic network that contains nanofabricated pillar structures.

The device has fluidic inputs for adding sample and reagents, removing waste, for carrying out DNA purification, and critically an integrated chamber for amplifying only the target DNA in the sample using the polymerase chain reaction (PCR) system. The chip also contains a wave guide for the fluorescence-based identification of the amplified DNA and thus the target microbe. Importantly, the system works without manual intervention other than loading a droplet of sample into the detector.

"The average time required for DNA purification during these experiments was approximately 15 min, and when combined with real-time PCR analysis, this resulted in an average time to detection of 60 min," the team says. The system can detect as few as 40 B. anthracis cells. "Due to its small size and low power requirements, this system can be further developed as a truly portable, hand-held device," the researchers conclude.


Contact: Nathaniel C. Cady
Inderscience Publishers

Related biology news :

1. Sensitive nanowire disease detectors made by Yale scientists
2. Electromagnetic phantom exorcises specters of metal detector tests
3. Pitt-led researchers create quick, simple fluorescent detector for TB
4. A quicker, cheaper SARS virus detector -- one easily customizable for other targets
5. UD start-up company prepares to commercialize novel detector for medical, military applications
6. Students design early labor detector to prevent premature births
7. $4.3 million DARPA grant enables development of biological and chemical threat detector
8. Livermore researchers develop battery-less chemical detector
9. Rice-born detector finds heaviest antimatter
10. Deadly rugby virus spreads in sumo wrestlers
11. 15-state Southern obesity summit to focus on deadly epidemic
Post Your Comments:
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
(Date:6/23/2016)... CA (PRWEB) , ... June 23, 2016 , ... ... software, is exhibiting at the Pennsylvania Convention Center and will showcase its product’s ... conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials ...
(Date:6/23/2016)... -- Amgen (NASDAQ: AMGN ) today announced a ... sciences incubator to accelerate the development of new therapies ... QB3@953 was created to help high-potential life science and ... stage organizations - access to laboratory infrastructure. ... "Amgen Golden Ticket" awards, providing each winner with one ...
(Date:6/22/2016)... Research and Markets has announced the addition of the ... The global biomarkers market has ... The market is expected to grow at a five-year compound annual ... $50.6 billion in 2015 to $96.6 billion in 2020. ... to 2020) are discussed. As well, new products approved in 2013 ...
Breaking Biology Technology: