Navigation Links
Naked mole-rats bear lifesaving clues
Date:2/23/2012

Could blind, buck-toothed, finger-sized naked mole-rats harbor in their brain cells a survival secret that might lead to better heart attack or stroke treatments?

University of Illinois at Chicago biologist Thomas Park and colleagues at UIC and the University of Texas Heath Science Center at San Antonio think the subterranean lifestyle of the pasty-looking rodents may indeed hold clues to keeping brain cells alive and functioning when oxygen is scarce. The key may lie in how brain cells regulate their intake of calcium.

"Normally, calcium in brain cells does wonderful things, including forming memories," says Park, who is professor of biological sciences at UIC. "But too much calcium makes things go haywire."

Brain cells starved of oxygen can't regulate calcium entry, and too much calcium in the cell is lethal. When a heart attack or stroke prevents oxygenated blood from reaching the brain, brain damage or death results.

Naked mole-rats, however, are very tolerant to oxygen deprivation, or hypoxia -- as are human newborns, whose brain cells have calcium channels that close during oxygen deprivation, protecting the cells from calcium overdose. With age, these calcium channels no longer close, which normally isn't a problem -- except during a heart attack.

Naked mole-rats retain a tolerance for oxygen deprivation into adulthood. Park and his colleagues measured calcium entry in brain tissue that had been kept under oxygen-poor conditions, reporting their findings online Feb. 21 in PLoS One.

"We knew the adults of this unusual mammal had brains that, like infant humans, were very tolerant to oxygen deprivation," he said. "We wanted to know if the adult naked mole-rats used the same strategy as babies to prevent calcium entry. This is exactly what we found."

Park thinks this strategy is an evolutionary adaptation by mole-rats, which live in the hundreds underground in tight, oxygen-deprived condi
'/>"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bottom of the swimming league: Naked mole rat sperm
2. Barshop Institute, global team sequences DNA of naked mole rat
3. Naked penguins baffle experts
4. New Naked Scientists series investigates our oceans
5. Serendipity leads to lifesaving discovery
6. Cleveland Clinic joins 23andMe in the search for genetic clues to Parkinsons disease
7. A bugs (sex) life: Diving beetles offer unexpected clues about sexual selection
8. Spasticity gene finding provides clues to causes of nerve cell degeneration
9. Ancient dry spells offer clues about the future of drought
10. Neurons grown from skin cells may hold clues to autism
11. Hydrogen peroxide provides clues to immunity, wound healing and tumor biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... promotional pricing and making the Wocket generally available for $229 ... Head of Marketing said, "We,ve extended the opportunity to take ... May. To get your wocket at this special price, submit ... on June 1, you,ll receive a unique code that gives ...
(Date:5/22/2015)... , May 22, 2015 According ... by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, ... (Government and Utilities, Consumer and Home) - Global Forecast ... grow from $2.77 Billion in 2015 to $6.19 Billion ... Browse 79 market data Tables and   43 ...
(Date:5/21/2015)... , May 21, 2015 ... "Thermal Imaging Market by Solutions (Hardware, Software, Services), by ... Automotive & others), by End-Users (Military & Defense ... by MarketsandMarkets, Thermal Imaging Market is expected to ... Million by 2020, at a Compound Annual Growth ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 2NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 3Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4
... toying with the idea of designing biological molecules that ... Pennsylvania researchers have developed a way to form these ... more important, have developed a new microscope technique that ... devices. The research was conducted by Dawn Bonnell, ...
... 08, 2011) A team of scientists has developed a ... into 3-D spheres. Their discovery takes advantage of an earlier ... promises more accurate tests of new cancer therapies. As ... "Sometimes engineering research tends to be a case of a ...
... the term "mutation" to describe a change in an individual ... its DNA. But the term has also achieved a ... which individuals gain exceptional, often malign, characteristics. The idea ... of evolution by natural selection and in his new book ...
Cached Biology News:Penn researchers develop biological circuit components, new microscope technique for measuring them 2Penn researchers develop biological circuit components, new microscope technique for measuring them 3New 3-D tumor model 2Noted science historian Elof Carlson traces how the idea of mutation has changed in 6 generations 2
(Date:5/20/2015)... May 20, 2015 Research and Markets ... "Top Technologies in HW_Technical Insights" report to ... report evaluated technology trends in the Health and Wellness ... likely to have an impact in the year 2015. ... the top 10 health and wellness technologies that are ...
(Date:5/20/2015)... 20, 2015 The global genotyping market ... during the forecast period of 2015 to 2020 to ... used in drug discovery and development process and to ... In addition to this,heavy investments by key manufacturers to ... also propelling market growth. Browse 113 market data tables ...
(Date:5/20/2015)... Mass. , May 20, 2015  Haemonetics Corporation ... Concannon , President & CEO, will present at The ... York on June 1 st , 2015 ... may access Mr. Concannon,s presentation live via webcast at: ... Haemonetics (NYSE: HAE ) is a global ...
(Date:5/20/2015)... PARK, North Carolina , 20. ... führende Unternehmen für klinische Logistik (Clinical ... für das Geschäftsjahr 2014, das am ... eingereicht. Das Unternehmen hat die Marktentwicklung ... Logo - http://photos.prnewswire.com/prnh/20110930/NY78064LOGO ...
Breaking Biology Technology:Top Technologies in the Health and Wellness Industry 2015 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... Nov. 12 /Xinhua-PRNewswire/ -- WuXi PharmaTech (NYSE:,WX), a ... outsourcing company with operations in China and the ... Ying Han to its Board of,Directors., From ... Asiainfo as Chief,Financial Officer and Executive Vice President. ...
... Calif., Nov. 12 Beckman,Coulter, Inc. (NYSE: ... and marketer,of products that simplify, automate, and ... Slacik, Beckman Coulter,s senior vice,president and chief ... Capital,Markets 5th Annual Healthcare Conference on Tuesday, ...
... Nov. 12 SpineSmith Partners, an,innovative bio-medical ... teams in The University of Texas Biomedical ... design, engineering, and commercialization,process of medical devices., ... groups of biomedical engineering students will work ...
Cached Biology Technology:WuXi PharmaTech Appoints Ying Han to Its Board of Directors 2SpineSmith Partners Collaborates with University of Texas Biomedical Engineering Students to Develop Innovative Products 2
... Incubator/Shaker HT is designed for ... Incubator/Shaker HT is ideal for ... and primer extension assays. The ... as a one-cabinet model, allowing ...
... Beta-Agarase is useful in recovering DNA ... Beta-Agarase digests the agarose into oligo- ... Heat Inactivation: 65C, 15 min Molecular ... Purity: Tested for contaminating endonucleases, exonucleases ...
iEMS Thermal Microplate Holder...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
Biology Products: