Navigation Links
NYU scientists identify critical protein complex in formation of cell cilia
Date:8/19/2008

NEW YORK, August 19, 2008 An international team led by NYU Cancer Institute have identified a protein complex that regulates the formation of cilia, which are found on virtually all mature human cells and are essential to normal cell function.

The new report, published this week by Developmental Cell and selected as the featured publication of the open-access online edition, describes how three proteins work together to regulate the formation of primary cilia. The study led by Brian Dynlacht, Ph.D., professor of pathology and director of NYU Cancer Institute Genomics Facility, investigates these antenna-like structures, once thought to be vestigial remnants of cell evolution, which have recently emerged as a focal point of research in developmental cell biology.

"We are trying to understand the regulation of processes that are fundamental to normal cell development and health in humans," said William Y. Tsang, Ph.D., of the NYU School of Medicine and Cancer Institute, and first author of the paper. "Defective cilia are implicated in a wide range of serious illnesses such as polycystic kidney disease, retinal degeneration, and neurological disorders. Inappropriate activation of signaling molecules that normally reside at the primary cilium, may lead to certain cancers."

At the center of the process lies the protein CEP290, which normally promotes primary cilia formation in mature cells. Dr. Tsang and his colleagues discovered that a second protein, CP110, normally suppresses the function of CEP290 until cells are fully mature. At that point, CP110 is destroyed, freeing CEP290 to interact with a third protein, Rab8a, to promote cilia formation on the surface of the mature cell.

The team's findings may help to identify potential targets for future drug design.

"Ciliogenesis is a fundamental process. These structures are found in almost every type of human cell you can imagine," Dr. Tsang said. "If we can e
'/>"/>

Contact: Jennifer Berman
Jennifer.Berman@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
2. Smithsonian scientists discover new bird species
3. Scientists discover major genetic cause of colorectal cancer
4. Scientists overcome nanotech hurdle
5. Strange molecule in the sky cleans acid rain, scientists discover
6. Scientists team up in Houston to tackle global challenges
7. Scientists find elephant memories may hold key to survival
8. Scientists to assess Beijing Olympics air pollution control efforts
9. Scripps scientists will assess Beijing Olympics air pollution control efforts
10. Midge-hunting scientists tackle spread of devastating bluetongue virus
11. Scientists a step closer to producing fuel from bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... like bacteria and fungi can evade treatment by acquiring ... drugs. These permanent mutations were once thought to be ... a new study has shown that microorganisms can use ... epimutations -- to gain the benefits of drug resistance ... discovered in a fungus called Mucor circinelloides, it is ...
(Date:7/27/2014)... computer cannot always find the solution a user wants. ... of computers that analyze a massive data set together. ... to present you with targeted ads, and how Amazon ... But big data is about more than just marketing. ... generating unprecedented quantities of information. That data may hold ...
(Date:7/25/2014)... on the land now called California, and many of ... plants they used for food, fuel, tools, and ritual. ... habitat and natural resources. , Frank Lake, an ecologist ... lead a field trip to the Stone ... America,s 99th Annual Meeting, in Sacramento, Cal. this August. ...
Breaking Biology News(10 mins):Scientists discover new, noncommittal mechanism of drug resistance 2Scientists discover new, noncommittal mechanism of drug resistance 3New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... have found a surprising link between brain iron ... conditions ranging from autism to major depression., Appearing ... of Sciences this week, the study by ... utility of a powerful in silico approach for ...
... University associate research scientist Melha Mellata, a member of professor ... develop a vaccine against a leading poultry disease called avian ... part of a large, diverse group of microbes called extra-intestinal ... of complex brain, lung and urinary tract diseases in human, ...
... evidence supporting a harmful effect of exercise on joints in ... a review of studies published in this month,s issue of ... extremely popular leisure-time activity in many countries throughout the Western ... lifestyle. It is widely promoted in as being beneficial for ...
Cached Biology News:Researchers iron out new role for serotonin 2New insights into a leading poultry disease and its risks to human health 2New insights into a leading poultry disease and its risks to human health 3New insights into a leading poultry disease and its risks to human health 4
(Date:7/25/2014)... July 25, 2014 Amgen (NASDAQ: ... declared a $0.61 per share dividend for the third ... Sept. 5, 2014, to all stockholders of record as ... About Amgen Amgen is committed to ... serious illnesses by discovering, developing, manufacturing and delivering innovative ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 WABC Radio show ... Pet with Lorry Young will be hosting California-based Vet-Stem, ... about stem cell therapy in pets. Dr. Harman first ... of stem cell therapy for pets suffering from osteoarthritis and ... Regenerative Veterinary Medicine industry forward. , Young has invited Dr. ...
(Date:7/25/2014)... July 25, 2014 At the request ... granted a 60-day extension for the public comment period ... Rule for Model Aircraft established by Congress as part ... The 60-day extension establishes the new deadline for comments ... Department of Transportation/FAA notice published in the Federal Register ...
(Date:7/24/2014)... Calif. , July 24, 2014  Now available ... to home. Rehealth Regenerative Therapies , located in ... and other physically active people a new health option: ... Regardless of age, countless patients suffer from joint ... activities, such as muscle tears, torn rotator cuff, tennis ...
Breaking Biology Technology:Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3FAA Grants Comment Extension at the Request of AMA 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3
... October 14, 2010 ... ... --> ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var r in ...
... India at the PharmAsia... -- SAN FRANCISCO, October 13, 2010 ... ... ... var first_result; // Results are keyed by longUrl, so we need to grab the first one. for ...
... Oct. 13 Molecular Detection Inc. (MDI), a company ... accuracy of infectious disease diagnosis, today announced that its ... in a study conducted at St. George,s Healthcare NHS ... The study results were presented this week at HIS ...
Cached Biology Technology:550 People Across Europe Will Die Today From a Preventable Lung Disease 2550 People Across Europe Will Die Today From a Preventable Lung Disease 3550 People Across Europe Will Die Today From a Preventable Lung Disease 4550 People Across Europe Will Die Today From a Preventable Lung Disease 5550 People Across Europe Will Die Today From a Preventable Lung Disease 6550 People Across Europe Will Die Today From a Preventable Lung Disease 7550 People Across Europe Will Die Today From a Preventable Lung Disease 8550 People Across Europe Will Die Today From a Preventable Lung Disease 9Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 2Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 3Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 4Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 5Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 6Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 7Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 8Biopharma Leaders to Reveal Successful Strategies for China, India at the PharmAsia Summit in San Francisco 9Molecular Detection's Detect-Ready™ MRSA Assay Demonstrates Strong Performance In Independent Comparative Study From Leading UK Hospital 2Molecular Detection's Detect-Ready™ MRSA Assay Demonstrates Strong Performance In Independent Comparative Study From Leading UK Hospital 3Molecular Detection's Detect-Ready™ MRSA Assay Demonstrates Strong Performance In Independent Comparative Study From Leading UK Hospital 4
UGT1A6 (D-20)...
... The OEM-EPC is the smallest ... 27 x 60 mm. Parker configured this ... life science OEM markets. Used in carrier ... flow control, liquid dispensing, and hydro-dynamic focusing, ...
... Thrust Slide is designed for heavy duty ... limited and substantial side-loading is present. Standard ... millions of trouble-free cycles even in high ... or recirculating ball bearings , Optional corrosion ...
... offered in several versions. The Captiva 0.2 ... are ideal to prepare precipitated protein samples ... and necessary to prevent clogging of expensive ... fiber and 20 um polypropylene filter plates ...
Biology Products: