Navigation Links
NYU researchers outline method for DNA computation in new book
Date:5/16/2011

Researchers at New York University's Courant Institute of Mathematical Sciences have outlined a method for storing programs inside DNA that simplifies nanocomputingcomputation at the molecular level. Co-authored by Jessie Chang and Dennis Shasha, Stored Clocked Programs Inside DNA: A Simplifying Framework for Nanocomputing (Morgan and Claypool) describes how to build millions of DNA programs from which instructions can be peeled away one at a time from each program in synchrony.

The motivation for this work is similar to that for stored programs inside your laptop. Before computers, there were mechanical calculators in which individuals would punch keys according to a procedure and a number would eventually appear. Once calculators became faster, it became clear that what needed improving was the punching process, not the rate of calculation. To do this, the first computer designers stored the programs containing "punching" instructions inside machines so they could run on their own. Once these instructions were stored, the entire computation could run at the speed of the machine.

Stored Clocked Programs Inside DNA offers a pathway for doing the same for DNA computing. While computers rely on data stored in strings of 0s and 1s, DNAthe building blocks of lifestores information in the molecules ("bases") represented by A, T, C, and G. Two single strands of DNA will bind if every A in one strand is aligned with every T in the other and similarly for the Cs and Gs. If only some of the bases of strand s1 are aligned with their favorite partners in s2, then another strand s3 with better alignment will push s1 out of the way. This phenomenon of "displacement" allows researchers to create DNA sculptures and nanorobots. However, like hand-held calculators, DNA computing currently relies on pouring test tubes of DNA into a larger test tube of DNA, hindering its speed and rendering its use delicate.

In their book, Shasha and Chang offer a method to store DNA instructions inside a chemical solution in a way that allows the computation process to run according to a global clock consisting of special strands of DNA called "tick" and "tock." Each time a "tick" and "tock" enter a DNA tube an instruction strand is released from an instruction stack. This is similar to the way a clock cycle in an electronic computer causes a new instruction to enter a processing unit. As long as there remain strands on the stack, the next cycle will release a new instruction strand. Regardless of the actual strand or component to be released at any particular clock step, the "tick" and "tock" strands remain the samein effect, serving as an automated input device and doing away with manual data entry.

Aidan Daly, a Harvard undergraduate on a summer internship at NYU, worked with Shasha and Chang to test their construction process in the laboratory of NYU Chemistry Professor Nadrian Seeman, who founded and developed the field of DNA nanotechnology. Seeman's creationsranging from three-dimensional DNA structures to a DNA assembly lineallow him to arrange pieces and form specific molecules on a nanoscale with some precision, similar to the way a robotic automobile factory can be told what kind of car to make.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related biology news :

1. Seaports need a plan for weathering climate change, Stanford researchers say
2. U of T researchers find link between childhood physical abuse, chronic fatigue syndrome
3. Rochester autism researchers present new findings at IMFAR
4. BU researchers identify extensive methane leaks under streets of Boston
5. UT Southwestern researchers find protein that might be key to cutting cancer cells blood supply
6. Striking the right balance: JBEI researchers counteract biofuel toxicity in microbes
7. Yale researchers explain why cancer smart drugs may not be so smart
8. Reforesting rural lands in China pays big dividends, Stanford researchers say
9. Chemistry researchers receive patent for new scientific measurement instrument
10. USDA researchers, collaborators sequence genomes of fungi that threaten wheat, poplars
11. Researchers get new view of how water and sulfur dioxide mix
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... , March 18, 2016 --> ... of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and ... security companies in the border security market and the continuing ... and Europe has led visiongain to ... improved success. --> defence & security companies ...
(Date:3/15/2016)... New York , March 15, 2016 ... new market report published by Transparency Market Research "Digital Door ... Trends and Forecast 2015 - 2023," the global digital door ... US$ 731.9 Mn in 2014 and is forecast to grow ... 2023. Growth of micro, small and medium enterprises (MSMEs) across ...
(Date:3/14/2016)... NXTD ) ("NXT-ID" or the "Company"), ... the airing of a new series of commercials on Time ... 21 st .  The commercials will air on Bloomberg TV, ... the Street show. --> NXTD ) ("NXT-ID" or ... market, announces the airing of a new series of commercials ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... medical devices used in spinal surgical procedures, today announced the completion of a ... value proposition for current and future customers and partners. Kohlberg & Company, ...
(Date:4/29/2016)... ... April 29, 2016 , ... During a ... technology into a viable company, CereScan’s CEO, John Kelley, joined other Denver business ... leader and mentor in the Denver area business community, shared his top fundamental ...
(Date:4/29/2016)... ... , ... Intelligent Implant Systems announced today that the two-level components for the ... United States. These components expand the capabilities of the system and allow Revolution™ ... October of 2015, the company has seen significant sales growth in 1Q 2016, and ...
(Date:4/28/2016)... -- The report "Cryocooler Market by Type ... Support, Product Repairs & Refurbishment, Preventive Maintenance, and Customer ... published by MarketsandMarkets, the global market is expected to ... CAGR of 7.29% between 2016 and 2022. ... spread through 159 Pages and in-depth TOC on  "Cryocooler ...
Breaking Biology Technology: