Navigation Links
NYU biologists identify proteins vital to chromosome segregation
Date:12/24/2012

New York University biologists have identified how a vital protein is loaded by others into the centromere, the part of the chromosome that plays a significant role in cell division. Their findings shed new light on genome replication and may offer insights into the factors behind the production of abnormal numbers of chromosomes.

Their findings appear in the latest issue of the journal the Proceedings of the National Academy of Sciences.

The researchers focused on the organization and functioning of the centromere, which is responsible for chromosome segregationa process that ensures that replicating cells receive a complete copy of the genome. Disruption of this process can lead to the production of an abnormal number of chromosomesa condition evident in 90 percent of cancer cases.

To explore the mechanics of the centromere, the researchers examined fission yeast. This species of yeast is a model organism in cell biology because its chromosome replication and the regulation of its centromere are similar to that of humans.

In the PNAS study, the researchers focused on a protein, CENP-A, present in both humans and fission yeast. They specifically examined how it is incorporated into the centromere during cell division in order to better understand its role in this process.

Their results identified that a trio of proteinsDos1, Dos2, and Cdc20work together to assemble CENP-A at centromeres as they duplicate. They further observed that any disruption of this process subsequently places this vital protein outside of the centromerethereby preventing it from performing its role of ensuring proper chromosome segregation.

"CENP-A is the engineer of the centromere," explained Fei Li, an assistant professor in NYU's Department of Biology and the study's senior author. "Without this protein, the centromere simply can't function."

Li noted that many forms of cancer have been linked to malfunctioning CENP-A.

"Hopefully, these findings can contribute toward the development of improved strategies for the diagnosis and treatment of cancer," he added.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Microbiologists can now measure extremely slow life
3. American Society of Plant Biologists honors early career women scientists
4. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
5. University of Toronto biologists predict extinction for organisms with poor quality genes
6. Biologists turn back the clock to understand evolution of sex differences
7. Double the pain: RUB biologists find the cause of pain in the treatment of fair skin cancer
8. UCLA biologists reveal potential fatal flaw in iconic sexual selection study
9. New book on stereology by Mark West is essential reading for neurobiologists
10. SF State biologists tag zombees to track their flight
11. Biologists unlocking the secrets of plant defenses, 1 piece at a time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... ivWatch LLC , a medical device company focused on improving the ... its ISO 13485 Certification, the global standard for medical device quality ... ... device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it validates ...
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... 22, 2017 , ... Precision Periodontics and Implant Dentistry's Dr. ... laser treatments. Drs. Hoge and Zalewsky are members of an elite class of ... painful option that produces real results. , "Like many of my colleagues, I ...
(Date:9/21/2017)... ... September 21, 2017 , ... Vixiar ... executive, engineering and manufacturing functions to The LaunchPort™ Accelerator at the City Garage ... full range of manufacturing and business services to its Residents. , Vixiar ...
(Date:9/21/2017)... ... September 21, 2017 , ... Colpitts Clinical has launched the ... includes new features that facilitate streamlined and compliant communication, file sharing and document ... forefront of medical advancements, they rely on efficiencies to help them address the ...
(Date:9/21/2017)... ... 2017 , ... When a downtown Greenville portion of the ... efficient thanks to the continuing efforts of members of the Reedy River Water ... stakeholders, including officials from area counties and cities, Renewable Water Resources (ReWa), community ...
Breaking Biology Technology: