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NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008
Date:7/25/2008

ical Center and Research Scientist, Nathan S. Kline Institute
EMBARGOED FOR RELEASE UNTIL SUNDAY, JULY 27, 2008 at 12:30 p.m. CT Researchers at NYU Langone Medical Center and the Nathan Kline Institute found that the inhibition of the calpain enzyme, which is involved in various cellular processes, led to a robust decrease in amyloid deposition in mice that develop plaque pathology commonly seen in Alzheimer's disease. Modulation of neuronal calpain activity presents a potential therapeutic approach to Alzheimer's, they report.
Presentation #P1-079


Partial gene-deletion improves memory dysfunction in Alzheimer's mice
Masuo Ohno, Ph.D., NYU Langone Medical Center and head of the Laboratory of Molecular and Cellular Cognition, Center for Dementia Research at the Nathan Kline Institute
EMBARGOED FOR RELEASE UNTIL SUNDAY, JULY 27, 2008 at 12:30 p.m. CT

An animal study by NYU researchers reveals that partially inhibiting an enzyme that initiates the release of amyloid beta led to an improvement in neuronal and cognitive deficits in mice that produced excessive amounts of the plaque forming protein. The approach poses a possibility to rescue Alzheimer's-related deficits, the researchers report.
Presentation #P1-092


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Contact: Bob Brody
bobbrody@hotmail.com
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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